Tumours of Haematopoietic and Lymphoid Tissues

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Myeloproliferative Neoplasms (MPN) (Overview Page Link)

Mastocytosis (Overview Page Link)

Myeloid/Lymphoid Neoplasms with Eosinophilia and Rearrangement of PDGFRA, PDGFRB or FGFR1, or with PCM1-JAK2 (Overview Page Link)

Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN) (Overview Page Link)

Myelodysplastic Syndromes (MDS) (Overview Page Link)

Myeloid Neoplasms with Germline Predisposition (Overview Page Link)

Acute Myeloid Leukemia (AML) and Related Precursor Neoplasms (Overview Page Link)

  - AML with t(8;21)(q22;q22.1); RUNX1-RUNX1T1
  - AML with with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11
  - HAEM5:Acute promyelocytic leukaemia with PML::RARA fusion
  - AML with t(9;11)(p21.3;q23.3); KMT2A-MLLT3
  - AML with t(6;9)(p23;q34.1); DEK-NUP214
  - AML with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2);GATA2, MECOM
  - AML Megakaryoblastic with t(1;22)(p13.3;q13.1);RBM15-MKL1
  - AML with BCR-ABL1
  - AML with Mutated NPM1
  - AML with Biallelic Mutations of CEBPA
  - AML with Mutated RUNX1

  - AML with Minimal Differentiation
  - AML without Maturation
  - AML with Maturation
  - HAEM5:Acute myelomonocytic leukaemia
  - HAEM5:Acute monocytic leukaemia
  - HAEM5:Acute erythroid leukaemia
  - HAEM5:Acute megakaryoblastic leukaemia
  - HAEM5:Acute basophilic leukaemia
  - HAEM4:Acute Panmyelosis with Myelofibrosis

  - HAEM5:Myeloid proliferations associated with Down syndrome
  - HAEM5:Myeloid proliferations associated with Down syndrome

Blastic Plasmacytoid Dendritic Cell Neoplasm (Overview Page Link)

Acute Leukemias of Ambiguous Lineage (MPAL) (Overview Page Link)

  - HAEM5:Acute undifferentiated leukaemia
  - HAEM5:Mixed-phenotype acute leukaemia with BCR::ABL1 fusion
  - HAEM5:Mixed-phenotype acute leukaemia with KMT2A rearrangement
  - HAEM5:Mixed-phenotype acute leukaemia, B/myeloid
  - HAEM5:Mixed-phenotype acute leukaemia, T/myeloid
  - HAEM5:Mixed-phenotype acute leukaemia, rare types
  - HAEM4:Acute Leukemias of Ambiguous Lineage, Not Otherwise Specified (NOS)

Precursor Lymphoid Neoplasms (B-ALL, T-ALL) (Overview Page Link)

  - B-ALL with t(9;22)(q34.1;q11.2); BCR-ABL1
  - B-ALL with t(v;11q23.3); KMT2A-Rearranged
  - B-ALL with t(12;21)(p13.2;q22.1); ETV6-RUNX1
  - B-ALL with Hyperdiploidy
  - B-ALL with Hypodiploidy
  - B-ALL with t(5;14)(q31.1;q32.1); IGH/IL3
  - B-ALL with t(1;19)(q23;p13.3); TCF3-PBX1
  - B-ALL, BCR-ABL1-Like
  - B-ALL with iAMP21
  - B-ALL, Not Otherwise Specified

  - HAEM5:Early T-precursor lymphoblastic leukaemia / lymphoma
  - HAEM4:NK-Lymphoblastic Leukemia/Lymphoma

Mature B-Cell Neoplasms (CLL, Plasma Cell Neoplasms, Non-Hodgkin B-cell Lymphomas) (Overview Page Link)

  - HAEM5:Monoclonal B-cell lymphocytosis

  - HAEM5:Splenic diffuse red pulp small B-cell lymphoma
  - HAEM5:Hairy cell leukaemia Variant

  - HAEM5:Lymphoplasmacytic lymphoma

  - HAEM5:Mu heavy chain disease
  - HAEM5:Gamma heavy chain disease
  - HAEM5:Alpha heavy chain disease

  - HAEM5:Non-IgM monoclonal gammopathy of undetermined significance
  - HAEM5:Plasma cell myeloma / multiple myeloma
  - HAEM5:Plasma cell myeloma / multiple myeloma Variants
  - HAEM5:Plasmacytoma
  - HAEM4:Monoclonal Immunoglobulin Deposition Diseases
        - HAEM5:Immunoglobulin-related (AL) amyloidosis
        - HAEM5:Monoclonal immunoglobulin deposition disease
  - HAEM4:Plasma Cell Neoplasms with Associated Paraneoplastic Syndrome
        - HAEM5:Plasma cell neoplasms with associated paraneoplastic syndrome
        - HAEM5:Plasma cell neoplasms with associated paraneoplastic syndrome

  - HAEM5:Paediatric nodal marginal zone lymphoma

  - HAEM5:Follicular lymphoma
  - HAEM5:In situ follicular B-cell neoplasm
  - HAEM5:Duodenal-type follicular lymphoma

  - HAEM5:Leukaemic non-nodal mantle cell lymphoma
  - HAEM5:In situ mantle cell neoplasm

  - HAEM5:Fibrin-associated large B-cell lymphoma

  - HAEM5:KSHV/HHV8-associated multicentric Castleman disease
  - HAEM5:KSHV/HHV8-positive diffuse large B-cell lymphoma
  - HAEM5:KSHV/HHV8-positive germinotropic lymphoproliferative disorder

  - HAEM4:High-Grade B-cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements
  - HAEM4:High-Grade B-cell Lymphoma, Not Otherwise Specified (NOS)

Mature T- and NK-cell Neoplasms (Overview Page Link)

  - HAEM5:Systemic EBV-positive T-cell lymphoma of childhood
  - HAEM5:Systemic chronic active EBV disease
  - HAEM5:Hydroa vacciniforme lymphoproliferative disorder
  - HAEM5:Severe mosquito bite allergy

  - HAEM5:Enteropathy-associated T-cell lymphoma
  - HAEM5:Monomorphic epitheliotropic intestinal T-cell lymphoma
  - HAEM4:Intestinal T-cell Lymphoma, Not Otherwise Specified (NOS)
  - HAEM5:Indolent T-cell lymphoma of the gastrointestinal tract

  - HAEM5:Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Lymphomatoid papulosis
  - HAEM5:Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Primary cutaneous anaplastic large cell lymphoma

  - HAEM5:Primary cutaneous gamma/delta T-cell lymphoma
  - HAEM5:Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma
  - HAEM5:Primary cutaneous acral CD8-positive T-cell lymphoproliferative disorder
  - HAEM5:Primary cutaneous CD4-positive small or medium T-cell lymphoproliferative disorder

  - HAEM5:Nodal TFH cell lymphoma, angioimmunoblastic-type
  - HAEM5:Nodal TFH cell lymphoma, follicular-type
  - HAEM5:Nodal TFH cell lymphoma, NOS

Hodgkin Lymphomas (Overview Page Link)

  - HAEM5:Classic Hodgkin lymphoma
  - HAEM5:Classic Hodgkin lymphoma
  - HAEM5:Classic Hodgkin lymphoma
  - HAEM5:Classic Hodgkin lymphoma

Immunodeficiency-Associated Lymphoproliferative Disorders (Overview Page Link)

  - HAEM4:Non-Destructive Post-Transplant Lymphoproliferative Disorders
  - HAEM5:Polymorphic lymphoproliferative disorders arising in immune deficiency / dysregulation
  - HAEM4:Monomorphic Post-Transplant Lymphoproliferative Disorders (B- and T/NK-cell Types)
        - HAEM4:Monomorphic B-cell PTLD
        - HAEM4:Monomorphic T/NK-cell PTLD
  - HAEM4:Classical Hodgkin Lymphoma Post-Transplant Lymphoproliferative Disorder

Histiocytic and Dendritic Cell Neoplasms (Overview Page Link)

  - HAEM5:Langerhans cell histiocytosis
  - HAEM5:Langerhans cell sarcoma

  - HAEM5:EBV-positive inflammatory follicular dendritic cell sarcoma

Notes

*The hierarchical tumour classification structure displayed on this page is reproduced from the WHO Classification of Tumours with permission from the copyright holder, ©International Agency for Research on Cancer.

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