Difference between revisions of "KMT2A(MLL)-MLLT6"
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(Created page with "Category:Gene Fusions One of several t(11;17) events that appear indentical down the microscope <ref> Strehl et al. Molecular dissection of t(11;17) in acute myeloid le...") |
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[[Category:Gene Fusions]] | [[Category:Gene Fusions]] | ||
| + | [[Category:Gene Fusions in ALL]] | ||
| + | [[Category:Gene Fusions in AML]] | ||
| − | One of several t(11;17) events that appear | + | One of several t(11;17) events that appear identical down the microscope. The KMT2A-MLLT6 chimeric protein consists of the C-terminal AT-hook DNA-binding, methyltransferase and CXXC zinc-finger domains of KMT2A along with the highly conserved octapeptide and the leucine-zipper dimerization motifs of MLLT6<ref> Strehl et al. |
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| − | <ref> Strehl et al. | ||
Molecular dissection of t(11;17) in acute myeloid leukemia reveals a variety of gene fusions with heterogeneous fusion transcripts and multiple splice variants. | Molecular dissection of t(11;17) in acute myeloid leukemia reveals a variety of gene fusions with heterogeneous fusion transcripts and multiple splice variants. | ||
| − | Genes Chromosomes Cancer. 2006 45:1041-9. | + | Genes Chromosomes Cancer. 2006 45:1041-9.[http://www.ncbi.nlm.nih.gov/pubmed/?term=16897742 PMID: 16897742]<\ref> |
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| − | [http://www.ncbi.nlm.nih.gov/pubmed/?term=16897742 PMID: 16897742]<\ref> | ||
Latest revision as of 09:37, 10 March 2016
One of several t(11;17) events that appear identical down the microscope. The KMT2A-MLLT6 chimeric protein consists of the C-terminal AT-hook DNA-binding, methyltransferase and CXXC zinc-finger domains of KMT2A along with the highly conserved octapeptide and the leucine-zipper dimerization motifs of MLLT6<ref> Strehl et al.
Molecular dissection of t(11;17) in acute myeloid leukemia reveals a variety of gene fusions with heterogeneous fusion transcripts and multiple splice variants.
Genes Chromosomes Cancer. 2006 45:1041-9.PMID: 16897742<\ref>