Compendium of Cancer Genome Aberrations

Changes

B-ALL Tables: Prognostic Genomic Abnormalities and Recurrent Gene Fusions (view source)

Revision as of 10:50, 26 July 2021

1,951 bytes added ,  10:50, 26 July 2021
m
Jennelleh moved page B-ALL table to B-ALL Tables: Prognostic Genomic Abnormalities and Recurrent Gene Fusions without leaving a redirect: Final name
Line 1: Line 1: −
'''Table 1 - Gene fusions reported in Ph-like B-ALL and other new B-ALL molecular subtypes (Literature Review)'''. Table derived from Akkari et al., 2020 [PMID 32302940] with permission from Cancer Genetics.
+
'''Table 1 - Prevalence and prognosis of B-ALL genomic abnormalities in the pediatric and adult population for all categories reported to date.''' Of the Ph-like category, only CRLF2 and ABL1-class rearrangements are indicated. Table derived from Akkari et al., 2020 [PMID 32302940] with permission from Cancer Genetics. All percentages are approximate.
 +
{| class="wikitable"
 +
|
 +
| colspan="2" |'''Percentage of B-ALL Cases'''
 +
|
 +
|-
 +
|'''Genomic abnormality'''
 +
|'''Pediatric'''
 +
|'''Adult'''
 +
|'''Prognosis'''
 +
|-
 +
|t(12;21)(p13;q22); [[ETV6]]-[[RUNX1]]*
 +
|25%
 +
|3%
 +
|Favorable
 +
|-
 +
|Hyperdiploidy*
 +
|25%
 +
|5-7%
 +
|Favorable
 +
|-
 +
|t(9;22)(q34;q11.2); [[BCR]]-[[ABL1]]*
 +
|2-4%
 +
|25-30%
 +
|Poor (outcome may improve with TKI)
 +
|-
 +
|[[CRLF2]] (PAR1, Xp22.33/Yp11.2) (Ph-like)
 +
|5%
 +
|20%
 +
|Poor
 +
|-
 +
|ABL-Class fusions (Ph-like)
 +
|3-5%
 +
|2-3%
 +
|Poor (outcome may improve with TKI)
 +
|-
 +
|[[KMT2A Partner Genes|KMT2A]] (11q23) rearrangements*
 +
|5%
 +
|10%
 +
|Poor
 +
|-
 +
|t(1;19)(q23;p13.3); [[TCF3]]-[[PBX1]]*
 +
|5%
 +
|3%
 +
|Favorable
 +
|-
 +
|[[TCF3]] (19p13.3) rearrangements (excluding [[ZNF384]])
 +
|>1%
 +
|>1%
 +
|Extremely Poor
 +
|-
 +
|Hypodiploidy*
 +
|1-2%
 +
|15%
 +
|Poor
 +
|-
 +
|dic(9;12)(p13;p13)
 +
|1%
 +
|Rare
 +
|Favorable
 +
|-
 +
|dic(9:20)(p13;q11)
 +
|2%
 +
|1%
 +
|Favorable
 +
|-
 +
|t(4;14)(q35.2;q32); [[IGH-DUX4|IGH/DUX4]]
 +
|5-9%
 +
|5%
 +
|Favorable
 +
|-
 +
|t(5;14)(q31.1;q32.1); [[IGH]]/[[IL3]]*
 +
|1%
 +
|1%
 +
|Unknown
 +
|-
 +
|[[ZNF384]] (12p13.31) rearrangements
 +
|1-5%
 +
|2-7%
 +
|Favorable
 +
|-
 +
|iAMP21 ([[RUNX1]])*
 +
|2%
 +
|Rare
 +
|Poor
 +
|-
 +
|[[IKZF1]] deletions
 +
|15-20%
 +
|25-30%
 +
|Poor except in combination with ERG del
 +
|}
 +
<nowiki>*</nowiki>indicates 2016 WHO entities including provisional categories.
 +
 
 +
 
 +
'''Table 2 - Gene fusions reported in Ph-like B-ALL and other new B-ALL molecular subtypes (Literature Review)'''. Table derived from Akkari et al., 2020 [PMID 32302940] with permission from Cancer Genetics.
 
{| class="wikitable"
 
{| class="wikitable"
 
|'''Subtype'''
 
|'''Subtype'''
Line 13: Line 107:     
'''B-ALL'''
 
'''B-ALL'''
−
| rowspan="12" |'''''ABL1''''' (9q34)
+
| rowspan="12" |'''''[[ABL1]]'''''
−
|''CENPC1''
+
(9q34)
 +
|''[[CENPC1]]''
 
|t(4;9)(q13;q34)
 
|t(4;9)(q13;q34)
 
|''CENPC1-ABL1''
 
|''CENPC1-ABL1''
Line 21: Line 116:  
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|-
 
|-
−
|''ETV6''
+
|''[[ETV6]]''
 
|t(9;12)(q34;p13)
 
|t(9;12)(q34;p13)
 
|''ETV6-ABL1''
 
|''ETV6-ABL1''
Line 28: Line 123:  
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|-
 
|-
−
|''FOXP1''
+
|''[[FOXP1]]''
 
|t(3;9)(p13;q34)
 
|t(3;9)(p13;q34)
 
|''FOXP1-ABL1'' on der(3)
 
|''FOXP1-ABL1'' on der(3)
Line 35: Line 130:  
|
 
|
 
|-
 
|-
−
|''LSM14A''
+
|''[[LSM14A]]''
 
|t(9;19)(q34;q13.1)
 
|t(9;19)(q34;q13.1)
 
|''LSM14A-ABL1'' on der(19)
 
|''LSM14A-ABL1'' on der(19)
Line 42: Line 137:  
|
 
|
 
|-
 
|-
−
|''NUP153''
+
|''[[NUP153]]''
 
|t(6;9)(p22.3;q34)
 
|t(6;9)(p22.3;q34)
 
|''NUP153-ABL1'' on der(6)
 
|''NUP153-ABL1'' on der(6)
Line 49: Line 144:  
|
 
|
 
|-
 
|-
−
|''NUP214''
+
|''[[NUP214]]''
 
|dup(9)(q34.1q34.1)
 
|dup(9)(q34.1q34.1)
 
|''NUP214-ABL1''
 
|''NUP214-ABL1''
Line 56: Line 151:  
|Tandem duplication (~370 kb) detectable by CMA
 
|Tandem duplication (~370 kb) detectable by CMA
 
|-
 
|-
−
|''RANBP2''
+
|''[[RANBP2]]''
 
|t(2;9)(q12.3;q34)
 
|t(2;9)(q12.3;q34)
 
|''RANBP-ABL1'' on der(2)
 
|''RANBP-ABL1'' on der(2)
Line 63: Line 158:  
|
 
|
 
|-
 
|-
−
|''RCSD1''
+
|''[[RCSD1]]''
 
|t(1;9)(q24.2;q34)
 
|t(1;9)(q24.2;q34)
 
|''RCSD1-ABL1'' on der(1)
 
|''RCSD1-ABL1'' on der(1)
Line 70: Line 165:  
|
 
|
 
|-
 
|-
−
|''SFPQ''
+
|''[[SFPQ]]''
 
|t(1;9)(p34.3;q34)
 
|t(1;9)(p34.3;q34)
 
|''SFPQ-ABL1'' on der(1)
 
|''SFPQ-ABL1'' on der(1)
Line 77: Line 172:  
|
 
|
 
|-
 
|-
−
|''SNX1''
+
|''[[SNX1]]''
 
|t(9;15)(q34;q22.3)
 
|t(9;15)(q34;q22.3)
 
|''SNX1-ABL1'' on der(15)
 
|''SNX1-ABL1'' on der(15)
Line 84: Line 179:  
|
 
|
 
|-
 
|-
−
|''SNX2''
+
|''[[SNX2]]''
 
|t(5;9)(q23.2;q34)
 
|t(5;9)(q23.2;q34)
 
|''SNX2-ABL1'' on der(5)
 
|''SNX2-ABL1'' on der(5)
Line 91: Line 186:  
|
 
|
 
|-
 
|-
−
|''ZMIZ1''
+
|''[[ZMIZ1]]''
 
|t(9;10)(q34;q22.3)
 
|t(9;10)(q34;q22.3)
 
|''ZMIZ1-ABL1'' on der(10)
 
|''ZMIZ1-ABL1'' on der(10)
Line 98: Line 193:  
|
 
|
 
|-
 
|-
−
| rowspan="3" |'''''ABL2''''' (1q25.2)
+
| rowspan="3" |'''''[[ABL2]]'''''
−
|''PAG1''
+
(1q25.2)
 +
|''[[PAG1]]''
 
|t(1;8)(q25.2;q21.1)
 
|t(1;8)(q25.2;q21.1)
 
|''PAG1-ABL2'' on der(1)
 
|''PAG1-ABL2'' on der(1)
Line 106: Line 202:  
|
 
|
 
|-
 
|-
−
|''RCSD1''
+
|''[[RCSD1]]''
 
|1q24.2q25.2 rearrangement
 
|1q24.2q25.2 rearrangement
 
|''RCSD1-ABL2''
 
|''RCSD1-ABL2''
Line 113: Line 209:  
|On the same chromosome arm; however, a simple deletion cannot cause the fusion due to the orientation of genes
 
|On the same chromosome arm; however, a simple deletion cannot cause the fusion due to the orientation of genes
 
|-
 
|-
−
|''ZC3HAV1''
+
|''[[ZC3HAV1]]''
 
|t(1;7)(q25.2;q34)
 
|t(1;7)(q25.2;q34)
 
|''ZC3HAV1-ABL2'' on der(1)
 
|''ZC3HAV1-ABL2'' on der(1)
Line 120: Line 216:  
|
 
|
 
|-
 
|-
−
| rowspan="2" |'''''CRLF2'''''
+
| rowspan="2" |'''''[[CRLF2]]'''''
    
(Xp22.3 & Yp11.3)
 
(Xp22.3 & Yp11.3)
−
|''IGH''
+
|''[[IGH]]''
 
|t(X;14)(p22.3;q32) or
 
|t(X;14)(p22.3;q32) or
   Line 132: Line 228:  
|
 
|
 
|-
 
|-
−
|''P2RY8''
+
|''[[P2RY8]]''
 
|del(X)(p22.3p22.3) or del(Y)(p11.3p11.3)
 
|del(X)(p22.3p22.3) or del(Y)(p11.3p11.3)
 
|''P2RY8-CRLF2''
 
|''P2RY8-CRLF2''
Line 139: Line 235:  
|
 
|
 
|-
 
|-
−
| rowspan="3" |'''''CSF1R''''' (5q32)
+
| rowspan="3" |'''''[[CSF1R]]'''''
−
|''MEF2D''
+
(5q32)
 +
|''[[MEF2D]]''
 
|t(1;5)(q22;q32)
 
|t(1;5)(q22;q32)
 
|''MEF2D-CSF1R'' on der(5)
 
|''MEF2D-CSF1R'' on der(5)
Line 147: Line 244:  
|
 
|
 
|-
 
|-
−
|''SSBP2''
+
|''[[SSBP2]]''
 
|5q14.1q32 rearrangement
 
|5q14.1q32 rearrangement
 
|''SSBP2-CSF1R''
 
|''SSBP2-CSF1R''
Line 154: Line 251:  
|On the same chromosome arm; however, a simple deletion cannot cause the fusion due to the orientation of genes
 
|On the same chromosome arm; however, a simple deletion cannot cause the fusion due to the orientation of genes
 
|-
 
|-
−
|''TBL1XR1''
+
|''[[TBL1XR1]]''
 
|t(3;5)(q26.3;q32)
 
|t(3;5)(q26.3;q32)
 
|''TBL1XR1-CSF1R'' on der(5)
 
|''TBL1XR1-CSF1R'' on der(5)
Line 161: Line 258:  
|
 
|
 
|-
 
|-
−
|'''''DGKH''''' (13q14.1)
+
|'''''[[DGKH]]''''' (13q14.1)
−
|''ZFAND3''
+
|''[[ZFAND3]]''
 
|t(6;13)(p21.2;q14.1)
 
|t(6;13)(p21.2;q14.1)
 
|''ZFAND3-DGKH''
 
|''ZFAND3-DGKH''
Line 169: Line 266:  
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|-
 
|-
−
| rowspan="4" |'''''EPOR''''' (19p13.2)
+
| rowspan="4" |'''''[[EPOR]]''''' (19p13.2)
−
|''IGH''
+
|''[[IGH]]''
 
|ins(14;19)(q32;p13.2p13.2)
 
|ins(14;19)(q32;p13.2p13.2)
 
|''IGH/EPOR''
 
|''IGH/EPOR''
Line 177: Line 274:  
|
 
|
 
|-
 
|-
−
|''IGK''
+
|''[[IGK]]''
 
|ins(2;19)(p11.2;p13.2p13.2)
 
|ins(2;19)(p11.2;p13.2p13.2)
 
|''IGK/EPOR''
 
|''IGK/EPOR''
Line 184: Line 281:  
|
 
|
 
|-
 
|-
−
|''LAIR1''
+
|''[[LAIR1]]''
 
|inv(19)(p13.2q13.42)
 
|inv(19)(p13.2q13.42)
 
|''LAIR1-EPOR''
 
|''LAIR1-EPOR''
Line 191: Line 288:  
|Inversion of chromosome 19 juxtaposes ''EPOR'' to the upstream region of ''LAIR1''
 
|Inversion of chromosome 19 juxtaposes ''EPOR'' to the upstream region of ''LAIR1''
 
|-
 
|-
−
|''THADA''
+
|''[[THADA]]''
 
|t(2;19)(p21;p13.2)
 
|t(2;19)(p21;p13.2)
 
|''THADA-EPOR''
 
|''THADA-EPOR''
Line 198: Line 295:  
|
 
|
 
|-
 
|-
−
|'''''IL2RB''''' (22q12.3)
+
|'''''[[IL2RB]]''''' (22q12.3)
−
|''MYH9''
+
|''[[MYH9]]''
 
|22q12.3 rearrangement
 
|22q12.3 rearrangement
 
|''MYH9-IL2RB''
 
|''MYH9-IL2RB''
Line 206: Line 303:  
|On the same chromosome arm; however, a simple deletion cannot cause the fusion due to the orientation of genes
 
|On the same chromosome arm; however, a simple deletion cannot cause the fusion due to the orientation of genes
 
|-
 
|-
−
| rowspan="22" |'''''JAK2''''' (9p24.1)
+
| rowspan="22" |'''''[[JAK2]]'''''
 +
(9p24.1)
   −
|''ATF7IP''
+
|''[[ATF7IP]]''
 
|t(9;12)(p24.1;p13.1)
 
|t(9;12)(p24.1;p13.1)
 
|''ATF7IP-JAK2'' on der(9)
 
|''ATF7IP-JAK2'' on der(9)
Line 215: Line 313:  
|
 
|
 
|-
 
|-
−
|''BCR''
+
|''[[BCR]]''
 
|t(9;22)(p24.1;q11.2)
 
|t(9;22)(p24.1;q11.2)
 
|''BCR-JAK2''
 
|''BCR-JAK2''
Line 222: Line 320:  
|Seen also in myeloproliferative neoplasms. Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|Seen also in myeloproliferative neoplasms. Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|-
 
|-
−
|''EBF1''
+
|''[[EBF1]]''
 
|t(5;9)(q33.3;p24.1)
 
|t(5;9)(q33.3;p24.1)
 
|''EBF1-JAK2'' on der(9)
 
|''EBF1-JAK2'' on der(9)
Line 229: Line 327:  
|
 
|
 
|-
 
|-
−
|''ETV6''
+
|''[[ETV6]]''
 
|t(9;12)(p24.1;p13.2)
 
|t(9;12)(p24.1;p13.2)
 
|''ETV6-JAK2'' on der(9)
 
|''ETV6-JAK2'' on der(9)
Line 236: Line 334:  
|
 
|
 
|-
 
|-
−
|''GOLGA5''
+
|''[[GOLGA5]]''
 
|t(9;14)(p24.1;q32.1)
 
|t(9;14)(p24.1;q32.1)
 
|''GOLGA5-JAK2''
 
|''GOLGA5-JAK2''
Line 243: Line 341:  
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|-
 
|-
−
|''HMBOX1''
+
|''[[HMBOX1]]''
 
|t(8;9)(p21.1;p24.1)
 
|t(8;9)(p21.1;p24.1)
 
|''HMBOX1-JAK2'' on der(9)
 
|''HMBOX1-JAK2'' on der(9)
Line 250: Line 348:  
|
 
|
 
|-
 
|-
−
|''OFD1''
+
|''[[OFD1]]''
 
|t(X;9)(p22.2;p24.1)
 
|t(X;9)(p22.2;p24.1)
 
|''OFD1-JAK2'' on der(9)
 
|''OFD1-JAK2'' on der(9)
Line 257: Line 355:  
|
 
|
 
|-
 
|-
−
|''PAX5''
+
|''[[PAX5]]''
 
|inv(9)(p13.2p24.1)
 
|inv(9)(p13.2p24.1)
 
|''PAX5-JAK2''
 
|''PAX5-JAK2''
Line 264: Line 362:  
|An inversion is required as genes are oriented in opposite directions
 
|An inversion is required as genes are oriented in opposite directions
 
|-
 
|-
−
|''PCM1''
+
|''[[PCM1]]''
 
|t(8;9)(p22;p24.1)
 
|t(8;9)(p22;p24.1)
 
|''PCM1-JAK2'' on der(9)
 
|''PCM1-JAK2'' on der(9)
Line 271: Line 369:  
|Seen also in myeloid/lymphoid neoplasms with eosinophilia
 
|Seen also in myeloid/lymphoid neoplasms with eosinophilia
 
|-
 
|-
−
|''PPFIBP1''
+
|''[[PPFIBP1]]''
 
|t(9;12)(p24.1;p11.2)
 
|t(9;12)(p24.1;p11.2)
 
|''PPFIBP1-JAK2'' on der(9)
 
|''PPFIBP1-JAK2'' on der(9)
Line 278: Line 376:  
|
 
|
 
|-
 
|-
−
|''RFX3''
+
|''[[RFX3]]''
 
|inv(9)(p24.1p24.2)
 
|inv(9)(p24.1p24.2)
 
|''RFX3-JAK2''
 
|''RFX3-JAK2''
Line 285: Line 383:  
|An inversion is required as genes are oriented in opposite directions
 
|An inversion is required as genes are oriented in opposite directions
 
|-
 
|-
−
|''SMU1''
+
|''[[SMU1]]''
 
|inv(9)(p21.1p24.1)
 
|inv(9)(p21.1p24.1)
 
|''SMU1-JAK2''
 
|''SMU1-JAK2''
Line 292: Line 390:  
|An inversion is required as genes are oriented in opposite directions
 
|An inversion is required as genes are oriented in opposite directions
 
|-
 
|-
−
|''SNX29''
+
|''[[SNX29]]''
 
|t(9;16)(p24.1;p13.1)
 
|t(9;16)(p24.1;p13.1)
 
|''SNX29-JAK2'' on der(9)
 
|''SNX29-JAK2'' on der(9)
Line 299: Line 397:  
|
 
|
 
|-
 
|-
−
|''SPAG9''
+
|''[[SPAG9]]''
 
|t(9;17)(p24.1;q21.3)
 
|t(9;17)(p24.1;q21.3)
 
|''SPAG9-JAK2'' on der(9)
 
|''SPAG9-JAK2'' on der(9)
Line 306: Line 404:  
|
 
|
 
|-
 
|-
−
|''SSBP2''
+
|''[[SSBP2]]''
 
|t(5;9)(q14.1;p24.1)
 
|t(5;9)(q14.1;p24.1)
 
|''SSBP2-JAK2'' on der(9)
 
|''SSBP2-JAK2'' on der(9)
Line 313: Line 411:  
|
 
|
 
|-
 
|-
−
|''STRN3''
+
|''[[STRN3]]''
 
|t(9;14)(p24.1;q12)
 
|t(9;14)(p24.1;q12)
 
|''STRN3-JAK2'' on der(9)
 
|''STRN3-JAK2'' on der(9)
Line 320: Line 418:  
|
 
|
 
|-
 
|-
−
|''TERF2''
+
|''[[TERF2]]''
 
|t(9;16)(p24.1;q22.1)
 
|t(9;16)(p24.1;q22.1)
 
|''TERF2-JAK2'' on der(9)
 
|''TERF2-JAK2'' on der(9)
Line 327: Line 425:  
|
 
|
 
|-
 
|-
−
|''TPR''
+
|''[[TPR]]''
 
|t(1;9)(q31.1;p24.1)
 
|t(1;9)(q31.1;p24.1)
 
|''TPR-JAK2'' on der(9)
 
|''TPR-JAK2'' on der(9)
Line 334: Line 432:  
|
 
|
 
|-
 
|-
−
|''USP25''
+
|''[[USP25]]''
 
|t(9;21)(p24.1;q21.1)
 
|t(9;21)(p24.1;q21.1)
 
|''USP25-JAK2''
 
|''USP25-JAK2''
Line 341: Line 439:  
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|-
 
|-
−
|''ZBTB46''
+
|''[[ZBTB46]]''
 
|t(9;20)(p24.1;q13.3)
 
|t(9;20)(p24.1;q13.3)
 
|''ZBTB46-JAK2'' on der(9)
 
|''ZBTB46-JAK2'' on der(9)
Line 348: Line 446:  
|
 
|
 
|-
 
|-
−
|''ZNF274''
+
|''[[ZNF274]]''
 
|t(9;19)(p24.1;q13.4)
 
|t(9;19)(p24.1;q13.4)
 
|''ZNF274-JAK2''
 
|''ZNF274-JAK2''
Line 355: Line 453:  
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|-
 
|-
−
|''ZNF340''
+
|''[[ZNF340]]''
 
|t(9;20)(p24.1;q13.3)
 
|t(9;20)(p24.1;q13.3)
 
|''ZNF340-JAK2'' on der(9)
 
|''ZNF340-JAK2'' on der(9)
Line 362: Line 460:  
|
 
|
 
|-
 
|-
−
|'''''PDGFRA'''''
+
|'''''[[PDGFRA]]'''''
    
(4q12)
 
(4q12)
−
|''FIP1L1''
+
|''[[FIP1L1]]''
 
|del(4)(q12q12)
 
|del(4)(q12q12)
 
|''FIP1L1-PDGFRA''
 
|''FIP1L1-PDGFRA''
Line 372: Line 470:  
|Interstitial deletion. Seen also in myeloid/lymphoid neoplasms with eosinophilia
 
|Interstitial deletion. Seen also in myeloid/lymphoid neoplasms with eosinophilia
 
|-
 
|-
−
| rowspan="8" |'''''PDGFRB''''' (5q32)
+
| rowspan="8" |'''''[[PDGFRB]]''''' (5q32)
−
|''ATF7IP''
+
|''[[ATF7IP]]''
 
|t(5;12)(q32;p13.1)
 
|t(5;12)(q32;p13.1)
 
|''ATF7IP-PDGFRB'' on der(5)
 
|''ATF7IP-PDGFRB'' on der(5)
Line 380: Line 478:  
|
 
|
 
|-
 
|-
−
|''EBF1''
+
|''[[EBF1]]''
 
|del(5)(q32q33.3)
 
|del(5)(q32q33.3)
 
|''EBF1-PDGFRB''
 
|''EBF1-PDGFRB''
Line 387: Line 485:  
|Interstitial deletion
 
|Interstitial deletion
 
|-
 
|-
−
|''ETV6''
+
|''[[ETV6]]''
 
|t(5;12)(q32;p13.2)
 
|t(5;12)(q32;p13.2)
 
|''ETV6-PDGFRB'' on der(5)
 
|''ETV6-PDGFRB'' on der(5)
Line 394: Line 492:  
|
 
|
 
|-
 
|-
−
|''SNX29''
+
|''[[SNX29]]''
 
|t(5;16)(q32;p13.1)
 
|t(5;16)(q32;p13.1)
 
|''SNX29-PDGFRB'' on der(5)
 
|''SNX29-PDGFRB'' on der(5)
Line 401: Line 499:  
|
 
|
 
|-
 
|-
−
|''SSBP2''
+
|''[[SSBP2]]''
 
|t(5;5)(q14.1;q32)
 
|t(5;5)(q14.1;q32)
 
|''SSBP2-PDGFRB''
 
|''SSBP2-PDGFRB''
Line 408: Line 506:  
|On the same chromosome arm; however, a simple deletion cannot cause the fusion due to the orientation of genes
 
|On the same chromosome arm; however, a simple deletion cannot cause the fusion due to the orientation of genes
 
|-
 
|-
−
|''TNIP1''
+
|''[[TNIP1]]''
 
|del(5)(q32q33.1)
 
|del(5)(q32q33.1)
 
|''TNIP1-PDGFRB''
 
|''TNIP1-PDGFRB''
Line 415: Line 513:  
|Interstitial deletion. Seen also in myeloid/lymphoid neoplasms with eosinophilia
 
|Interstitial deletion. Seen also in myeloid/lymphoid neoplasms with eosinophilia
 
|-
 
|-
−
|''ZEB2''
+
|''[[ZEB2]]''
 
|t(2;5)(q22.3;q32)
 
|t(2;5)(q22.3;q32)
 
|''ZEB2-PDGFRB'' on der(5)
 
|''ZEB2-PDGFRB'' on der(5)
Line 422: Line 520:  
|
 
|
 
|-
 
|-
−
|''ZMYND8''
+
|''[[ZMYND8]]''
 
|t(5;20)(q32;q13.1)
 
|t(5;20)(q32;q13.1)
 
|''ZMYND8-PDGFRB'' on der(5)
 
|''ZMYND8-PDGFRB'' on der(5)
Line 429: Line 527:  
|
 
|
 
|-
 
|-
−
| rowspan="3" |'''''PTK2B''''' (8p21.2)
+
| rowspan="3" |'''''[[PTK2B]]''''' (8p21.2)
−
|''KDM6A''
+
|''[[KDM6A]]''
 
|t(X;8)(p11.3;p21.2)
 
|t(X;8)(p11.3;p21.2)
 
|''KDM6A-PTK2B'' on der(8)
 
|''KDM6A-PTK2B'' on der(8)
Line 437: Line 535:  
|
 
|
 
|-
 
|-
−
|''STAG2''
+
|''[[STAG2]]''
 
|t(X;8)(q25;p21.2)
 
|t(X;8)(q25;p21.2)
 
|''STAG2-PTK2B''
 
|''STAG2-PTK2B''
Line 444: Line 542:  
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|-
 
|-
−
|''TMEM2''
+
|''[[TMEM2]]''
 
|t(8;9)(p21.2;q21.1)
 
|t(8;9)(p21.2;q21.1)
 
|''TMEM2-PTK2B'' on der(8)
 
|''TMEM2-PTK2B'' on der(8)
Line 451: Line 549:  
|
 
|
 
|-
 
|-
−
| rowspan="3" |'''''TYK2''''' (19p13.2)
+
| rowspan="3" |'''''[[TYK2]]''''' (19p13.2)
−
|''MYB''
+
|''[[MYB]]''
 
|t(6;19)(q23.3;p13.2)
 
|t(6;19)(q23.3;p13.2)
 
|''MYB-TYK2'' on der(6)
 
|''MYB-TYK2'' on der(6)
Line 459: Line 557:  
|
 
|
 
|-
 
|-
−
|''SMARCA4''
+
|''[[SMARCA4]]''
 
|inv(19)(p13.2p13.2)
 
|inv(19)(p13.2p13.2)
 
|''SMARCA4-TYK2''
 
|''SMARCA4-TYK2''
Line 466: Line 564:  
|
 
|
 
|-
 
|-
−
|''ZNF340''
+
|''[[ZNF340]]''
 
|t(19;20)(p13.2;q13.3)
 
|t(19;20)(p13.2;q13.3)
 
|''ZNF340-TYK2''
 
|''ZNF340-TYK2''
Line 474: Line 572:  
|-
 
|-
 
| rowspan="9" |'''''ZNF384-''rearranged B-ALL'''
 
| rowspan="9" |'''''ZNF384-''rearranged B-ALL'''
−
| rowspan="9" |'''''ZNF384''''' (12p13.3) '' ''
+
| rowspan="9" |'''''[[ZNF384]]''''' (12p13.3) '' ''
−
|''ARID1B''
+
|''[[ARID1B]]''
 
|t(6;12)(q25.3;p13.3)
 
|t(6;12)(q25.3;p13.3)
 
|''ARID1B-ZNF384''  on der(6)
 
|''ARID1B-ZNF384''  on der(6)
Line 482: Line 580:  
|
 
|
 
|-
 
|-
−
|''BMP2K''
+
|''[[BMP2K]]''
 
|t(4;12)(q21.2;p13.3)
 
|t(4;12)(q21.2;p13.3)
 
|''BMP2K-ZNF384''  on der(4)
 
|''BMP2K-ZNF384''  on der(4)
Line 489: Line 587:  
|
 
|
 
|-
 
|-
−
|''CREBBP''
+
|''[[CREBBP]]''
 
|t(12;16)(p13.3;p13.3)
 
|t(12;16)(p13.3;p13.3)
 
|''CREBBP-ZNF384'' on der(16)
 
|''CREBBP-ZNF384'' on der(16)
Line 496: Line 594:  
|
 
|
 
|-
 
|-
−
|''EP300''
+
|''[[EP300]]''
 
|t(12;22)(p13.3;q13.2)
 
|t(12;22)(p13.3;q13.2)
 
|''EP300-ZNF384'' on der(22)
 
|''EP300-ZNF384'' on der(22)
Line 503: Line 601:  
|
 
|
 
|-
 
|-
−
|''EWSR1''
+
|''[[EWSR1]]''
 
|t(12;22)(p13.3;q12.2)
 
|t(12;22)(p13.3;q12.2)
 
|''EWSR1-ZNF384'' on der(22)
 
|''EWSR1-ZNF384'' on der(22)
Line 510: Line 608:  
|
 
|
 
|-
 
|-
−
|''SMARCA2''
+
|''[[SMARCA2]]''
 
|t(9;12)(p24.3;p13.3)
 
|t(9;12)(p24.3;p13.3)
 
|''SMARCA2-ZNF384''
 
|''SMARCA2-ZNF384''
Line 517: Line 615:  
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|-
 
|-
−
|''SYNRG''
+
|''[[SYNRG]]''
 
|t(12;17)(p13.3;q12)
 
|t(12;17)(p13.3;q12)
 
|''SYNGR-ZNF384''
 
|''SYNGR-ZNF384''
Line 524: Line 622:  
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|-
 
|-
−
|''TAF15''
+
|''[[TAF15]]''
 
|t(12;17)(p13.3;q12)
 
|t(12;17)(p13.3;q12)
 
|''TAF15-ZNF384'' on der(17)
 
|''TAF15-ZNF384'' on der(17)
Line 531: Line 629:  
|
 
|
 
|-
 
|-
−
|''TCF3''
+
|''[[TCF3]]''
 
|t(12;19)(p13.3;p13.3)
 
|t(12;19)(p13.3;p13.3)
 
|''TCF3-ZNF384'' on der(19)
 
|''TCF3-ZNF384'' on der(19)
Line 539: Line 637:  
|-
 
|-
 
| rowspan="6" |'''''MEF2D-''rearranged B-ALL'''
 
| rowspan="6" |'''''MEF2D-''rearranged B-ALL'''
−
|''BCL9''
+
| rowspan="6" |'''''[[MEF2D]]'''''
−
| rowspan="6" |'''''MEF2D''''' (1q22)
+
(1q22)
 +
|''[[BCL9]]''
 
|inv(1)(q21.2q22)
 
|inv(1)(q21.2q22)
 
|''MEF2D-BCL9''
 
|''MEF2D-BCL9''
Line 547: Line 646:  
|
 
|
 
|-
 
|-
−
|''CSF1R''
+
|''[[CSF1R]]''
 
|t(1;5)(q22;q32)
 
|t(1;5)(q22;q32)
 
|''MEF2D-CSF1R'' on der(5)
 
|''MEF2D-CSF1R'' on der(5)
Line 554: Line 653:  
|
 
|
 
|-
 
|-
−
|''FOXJ2''
+
|''[[FOXJ2]]''
 
|t(1;12)(q22;p13.3)
 
|t(1;12)(q22;p13.3)
 
|''MEF2D-FOXJ2'' on der(12)
 
|''MEF2D-FOXJ2'' on der(12)
Line 561: Line 660:  
|
 
|
 
|-
 
|-
−
|''HNRNPH1''
+
|''[[HNRNPH1]]''
 
|t(1;5)(q22;q35.3)
 
|t(1;5)(q22;q35.3)
 
|''MEF2D-HNRNPH1'' on der(5)
 
|''MEF2D-HNRNPH1'' on der(5)
Line 568: Line 667:  
|
 
|
 
|-
 
|-
−
|''HNRNPUL1''
+
|''[[HNRNPUL1]]''
 
|t(1;19)(q22;q13.2)
 
|t(1;19)(q22;q13.2)
 
|''MEF2D-HNRNPUL1''
 
|''MEF2D-HNRNPUL1''
Line 575: Line 674:  
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
 
|-
 
|-
−
|''SS18''
+
|''[[SS18]]''
 
|t(1;18)(q22;q11.2)
 
|t(1;18)(q22;q11.2)
 
|''MEF2D-SS18'' on der(18)
 
|''MEF2D-SS18'' on der(18)
Retrieved from "https://ccga.io/index.php/Special:MobileDiff/10349...10354"