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Line 539: + − | rowspan="6" |'''''MEF2D''''' (1q22)
B-ALL Tables: Prognostic Genomic Abnormalities and Recurrent Gene Fusions (view source)
Revision as of 13:01, 22 July 2021
, 13:01, 22 July 2021Fixed a few cells of the table and added gene links
'''B-ALL'''
'''B-ALL'''
| rowspan="12" |'''''ABL1''''' (9q34)
| rowspan="12" |'''''[[ABL1]]''''' (9q34)
|''CENPC1''
|''CENPC1''
|t(4;9)(q13;q34)
|t(4;9)(q13;q34)
|
|
|-
|-
| rowspan="3" |'''''ABL2''''' (1q25.2)
| rowspan="3" |'''''[[ABL2]]''''' (1q25.2)
|''PAG1''
|''PAG1''
|t(1;8)(q25.2;q21.1)
|t(1;8)(q25.2;q21.1)
|
|
|-
|-
| rowspan="2" |'''''CRLF2'''''
| rowspan="2" |'''''[[CRLF2]]'''''
(Xp22.3 & Yp11.3)
(Xp22.3 & Yp11.3)
|
|
|-
|-
| rowspan="3" |'''''CSF1R''''' (5q32)
| rowspan="3" |'''''[[CSF1R]]''''' (5q32)
|''MEF2D''
|''MEF2D''
|t(1;5)(q22;q32)
|t(1;5)(q22;q32)
|
|
|-
|-
|'''''DGKH''''' (13q14.1)
|'''''[[DGKH]]''''' (13q14.1)
|''ZFAND3''
|''ZFAND3''
|t(6;13)(p21.2;q14.1)
|t(6;13)(p21.2;q14.1)
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
|Requires complex rearrangement due to incompatible orientation of genes with respect to chromosome arms
|-
|-
| rowspan="4" |'''''EPOR''''' (19p13.2)
| rowspan="4" |'''''[[EPOR]]''''' (19p13.2)
|''IGH''
|''IGH''
|ins(14;19)(q32;p13.2p13.2)
|ins(14;19)(q32;p13.2p13.2)
|
|
|-
|-
|'''''IL2RB''''' (22q12.3)
|'''''[[IL2RB]]''''' (22q12.3)
|''MYH9''
|''MYH9''
|22q12.3 rearrangement
|22q12.3 rearrangement
|On the same chromosome arm; however, a simple deletion cannot cause the fusion due to the orientation of genes
|On the same chromosome arm; however, a simple deletion cannot cause the fusion due to the orientation of genes
|-
|-
| rowspan="22" |'''''JAK2''''' (9p24.1)
| rowspan="22" |'''''[[JAK2]]''''' (9p24.1)
|''ATF7IP''
|''ATF7IP''
|
|
|-
|-
|'''''PDGFRA'''''
|'''''[[PDGFRA]]'''''
(4q12)
(4q12)
|Interstitial deletion. Seen also in myeloid/lymphoid neoplasms with eosinophilia
|Interstitial deletion. Seen also in myeloid/lymphoid neoplasms with eosinophilia
|-
|-
| rowspan="8" |'''''PDGFRB''''' (5q32)
| rowspan="8" |'''''[[PDGFRB]]''''' (5q32)
|''ATF7IP''
|''ATF7IP''
|t(5;12)(q32;p13.1)
|t(5;12)(q32;p13.1)
|
|
|-
|-
| rowspan="3" |'''''PTK2B''''' (8p21.2)
| rowspan="3" |'''''[[PTK2B]]''''' (8p21.2)
|''KDM6A''
|''KDM6A''
|t(X;8)(p11.3;p21.2)
|t(X;8)(p11.3;p21.2)
|
|
|-
|-
| rowspan="3" |'''''TYK2''''' (19p13.2)
| rowspan="3" |'''''[[TYK2]]''''' (19p13.2)
|''MYB''
|''MYB''
|t(6;19)(q23.3;p13.2)
|t(6;19)(q23.3;p13.2)
|-
|-
| rowspan="9" |'''''ZNF384-''rearranged B-ALL'''
| rowspan="9" |'''''ZNF384-''rearranged B-ALL'''
| rowspan="9" |'''''ZNF384''''' (12p13.3) '' ''
| rowspan="9" |'''''[[ZNF384]]''''' (12p13.3) '' ''
|''ARID1B''
|''ARID1B''
|t(6;12)(q25.3;p13.3)
|t(6;12)(q25.3;p13.3)
|-
|-
| rowspan="6" |'''''MEF2D-''rearranged B-ALL'''
| rowspan="6" |'''''MEF2D-''rearranged B-ALL'''
| rowspan="6" |'''''[[MEF2D]]''' (1q22)''
|''BCL9''
|''BCL9''
|inv(1)(q21.2q22)
|inv(1)(q21.2q22)
|''MEF2D-BCL9''
|''MEF2D-BCL9''