Tumours of Haematopoietic and Lymphoid Tissues

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Myeloproliferative Neoplasms (MPN)

Mastocytosis

Myeloid/Lymphoid Neoplasms with Eosinophilia and Rearrangement of PDGFRA, PDGFRB or FGFR1, or with PCM1-JAK2

Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN)

Myelodysplastic Syndromes (MDS)

Myeloid Neoplasms with Germline Predisposition

Acute Myeloid Leukemia (AML) and Related Precursor Neoplasms

  - AML with t(8;21)(q22;q22.1); RUNX1-RUNX1T1
  - AML with with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11
  - Acute Promyelocytic Leukemia (APL) with PML-RARA
  - AML with t(9;11)(p21.3;q23.3); KMT2A-MLLT3
  - AML with t(6;9)(p23;q34.1); DEK-NUP214
  - AML with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2);GATA2, MECOM
  - AML Megakaryoblastic with t(1;22)(p13.3;q13.1);RBM15-MKL1
  - AML with BCR-ABL1
  - AML with Mutated NPM1
  - AML with Biallelic Mutations of CEBPA
  - AML with Mutated RUNX1

  - AML with Minimal Differentiation
  - AML without Maturation
  - AML with Maturation
  - Acute Myelomonocytic Leukemia
  - Acute Monoblastic and Monocytic Leukemia
  - Pure Erythroid Leukemia
  - Acute Megakaryoblastic Leukemia (AMKL)
  - Acute Basophilic Leukemia
  - Acute Panmyelosis with Myelofibrosis

  - Transient Abnormal Myelopoiesis (TAM) Associated with Down Syndrome
  - Myeloid Leukemia Associated with Down Syndrome

Blastic Plasmacytoid Dendritic Cell Neoplasm

Acute Leukemias of Ambiguous Lineage (MPAL)

  - Acute Undifferentiated Leukemia
  - Mixed Phenotype Acute Leukemia (MPAL) with t(9;22)(q34.1;q11.2); BCR-ABL1
  - Mixed Phenotype Acute Leukemia (MPAL) with t(v;11q23.3); KMT2A Rearranged
  - Mixed Phenotype Acute Leukemia (MPAL), B/Myeloid, Not Otherwise Specified
  - Mixed Phenotype Acute Leukemia (MPAL), T/Myeloid, Not Otherwise Specified
  - Mixed-Phenotype Acute Leukemia, Not Otherwise Specified (NOS), Rare Types
  - Acute Leukemias of Ambiguous Lineage, Not Otherwise Specified (NOS)

Precursor Lymphoid Neoplasms (B-ALL, T-ALL)

  - B-ALL with t(9;22)(q34.1;q11.2); BCR-ABL1
  - B-ALL with t(v;11q23.3); KMT2A-Rearranged
  - B-ALL with t(12;21)(p13.2;q22.1); ETV6-RUNX1
  - B-ALL with Hyperdiploidy
  - B-ALL with Hypodiploidy
  - B-ALL with t(5;14)(q31.1;q32.1); IGH/IL3
  - B-ALL with t(1;19)(q23;p13.3); TCF3-PBX1
  - B-ALL, BCR-ABL1-Like
  - B-ALL with iAMP21
  - B-ALL, Not Otherwise Specified

  - Early T-Cell Precursor Lymphoblastic Leukemia
  - NK-Lymphoblastic Leukemia/Lymphoma

Mature B-Cell Neoplasms (CLL, Plasma Cell Neoplasms, Non-Hodgkin B-cell Lymphomas)

  - Monoclonal B-cell Lymphocytosis

  - Splenic Diffuse Red Pulp Small B-cell Lymphoma
  - Hairy Cell Leukemia Variant

  - Waldenstrom Macroglobulinemia

  - Mu Heavy Chain Disease
  - Gamma Heavy Chain Disease
  - Alpha Heavy Chain Disease

  - Non-IgM Monoclonal Gammopathy of Undetermined Significance
  - Plasma Cell Myeloma
  - Plasma Cell Myeloma Variants
  - Plasmacytoma
  - Monoclonal Immunoglobulin Deposition Diseases
        - Primary Amyloidosis
        - Light Chain and Heavy Chain Deposition Disease
  - Plasma Cell Neoplasms with Associated Paraneoplastic Syndrome
        - POEMS Syndrome
        - TEMPI Syndrome

  - Paediatric Nodal Marginal Zone Lymphoma

  - Testicular Follicular Lymphoma
  - In Situ Follicular Neoplasia
  - Duodenal-Type Follicular Lymphoma

  - Leukemic Non-Nodal Mantle Cell Lymphoma
  - In Situ Mantle Cell Neoplasia

  - Fibrin-Associated Diffuse Large B-cell Lymphoma

  - Multicentric Castleman Disease
  - HHV8-Positive Diffuse Large B-cell Lymphoma, Not Otherwise Specified (NOS)
  - HHV8-Positive Germinotropic Lymphoproliferative Disorder

  - High-Grade B-cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements
  - High-Grade B-cell Lymphoma, Not Otherwise Specified (NOS)

Mature T- and NK-cell Neoplasms

  - Systemic EBV-Positive T-cell Lymphoma of Childhood
  - Chronic Active EBV Infection of T- and NK-cell Type, Systemic Form
  - Hydroa Vacciniforme-Like Lymphoproliferative Disorder
  - Severe Mosquito Bite Allergy

  - Enteropathy-Associated T-cell Lymphoma
  - Monomorphic Epitheliotropic Intestinal T-cell Lymphoma
  - Intestinal T-cell Lymphoma, Not Otherwise Specified (NOS)
  - Indolent T-cell Lymphoproliferative Disorder of the Gastrointestinal Tract

  - Lymphomatoid Papulosis
  - Primary Cutaneous Anaplastic Large Cell Lymphoma

  - Primary Cutaneous Gamma Delta T-cell Lymphoma
  - Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-cell Lymphoma
  - Primary Cutaneous Acral CD8+ T-cell Lymphoma
  - Primary Cutaneous CD4+ Small/Medium T-cell Lymphoproliferative Disorder

  - Angioimmunoblastic T-cell Lymphoma
  - Follicular T-cell Lymphoma
  - Nodal Peripheral T-cell Lymphoma with T Follicular Helper Phenotype

Hodgkin Lymphomas

  - Nodular Sclerosis Classic Hodgkin Lymphoma
  - Lymphocyte-Rich Classic Hodgkin Lymphoma
  - Mixed Cellularity Classic Hodgkin Lymphoma
  - Lymphocyte-Depleted Classic Hodgkin Lymphoma

Immunodeficiency-Associated Lymphoproliferative Disorders

  - Non-Destructive Post-Transplant Lymphoproliferative Disorders
  - Polymorphic Post-Transplant Lymphoproliferative Disorders
  - Monomorphic Post-Transplant Lymphoproliferative Disorders (B- and T/NK-cell Types)
        - Monomorphic B-cell PTLD
        - Monomorphic T/NK-cell PTLD
  - Classical Hodgkin Lymphoma Post-Transplant Lymphoproliferative Disorder

Histiocytic and Dendritic Cell Neoplasms

  - Langerhans Cell Histiocytosis
  - Langerhans Cell Sarcoma

  - Inflammatory Pseudotumor-Like Follicular/Fibroblastic Dendritic Cell Sarcoma

NOTES The hierarchical tumour classification structure displayed on this page is reproduced from the WHO Classification of Tumours with permission from the copyright holder, ©International Agency for Research on Cancer.

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