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==WHO Classification of Tumours of the Central Nervous System Content==
==WHO Central Nervous System Tumours (5th ed.) Content==
{| class="wikitable"
{| class="wikitable"
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!'''Notes'''
!'''Notes'''
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|Medulloblastoma, WNT-activated||Disease||Lisa Lansdon, PhD (LGG trainee just finished), Midhat Farooqi, MD (mentor), Children's Mercy Hospital Kansas City
| Astrocytoma, IDH-mutant||Disease||
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|Diffuse Midline Glioma, H3 K27-Altered
| Oligodendroglioma, IDH-mutant and 1p/19q-codeleted||Disease||
|Disease
|Laveniya Satgunaseelan (Linda Cooley - previous version)
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|Diffuse Paediatric-Type High-Grade Glioma, H3-Wildtype and IDH-Wildtype
| Glioblastoma, IDH-wildtype||Disease||
|Disease
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|Infant-Type Hemispheric Glioma
| Diffuse astrocytoma, MYB- or MYBL1-altered||Disease||
|Disease
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|Astrocytoma, IDH-Mutant
| Angiocentric glioma||Disease||
|Disease
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|Riley Lochner (trainee), Shashi Shetty (mentor)
|3/3/2022
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|Ganglioglioma
| Polymorphous low-grade neuroepithelial tumour of the young||Disease||
|Disease
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|Leila Moayed-Aloei
|6/30/2022
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|NTRK-Rearranged Spindle Cell Neoplasm||Disease||James Solomon, MD, PhD
| Diffuse low-grade glioma, MAPK pathway-altered ||Disease||
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|Secretory Carcinoma
| Diffuse midline glioma, H3 K27-altered||Disease||
|Disease
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|PENDING
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|ABL1
| Diffuse hemispheric glioma, H3 G34-mutant||Disease||
|Brian Davis
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|Complete
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|6/9/19
| Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype||Disease||
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|MYH11
| Infant-type hemispheric glioma||Disease||
|Brian Davis
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|Complete
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| Pilocytic astrocytoma ||Disease||
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| High-grade astrocytoma with piloid features||Disease||
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| Pleomorphic xanthoastrocytoma||Disease||
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|CEBPA
| Subependymal giant cell astrocytoma||Disease||
|Gordana
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|IDH1
| Chordoid glioma||Disease||
|Paul De Fazio
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|IDH2
| Astroblastoma, MN1-altered||Disease||
|Paul De Fazio
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|PML
| Ganglioglioma||Disease||
|Brian Davis
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|Complete
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|8/3/18
| Gangliocytoma||Disease||
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|KIT
| Desmoplastic infantile ganglioglioma / desmoplastic infantile astrocytoma||Disease||
|Brian Davis
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|Complete
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|8/2/18
| Dysembryoplastic neuroepithelial tumour||Disease||
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| Diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters||Disease||
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|MLTT3
| Papillary glioneuronal tumour||Disease||
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| Rosette-forming glioneuronal tumour||Disease||
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|FGFR1(FLT2)
| Myxoid glioneuronal tumour||Disease||
|Brian Davis
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|KMT2A
| Diffuse leptomeningeal glioneuronal tumour||Disease||
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| Multinodular and vacuolating neuronal tumour||Disease||
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|NUP214
| Dysplastic cerebellar gangliocytoma (Lhermitte-Duclos disease)||Disease||
|Wahab A. Khan
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|RBM15
| Central neurocytoma||Disease||
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|MKL1
| Extraventricular neurocytoma||Disease||
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|ANKRD26
| Cerebellar liponeurocytoma||Disease||
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|CUX1
| Supratentorial ependymoma||Disease||
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|TET2
| Supratentorial ependymoma, ZFTA fusion-positive ||Disease||
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|EZH2
| Supratentorial ependymoma, YAP1 fusion-positive||Disease||
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|FOXP1
| Posterior fossa ependymoma||Disease||
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|MYC
| Posterior fossa group A (PFA) ependymoma||Disease||
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|JAK2
| Posterior fossa group B (PFB) ependymoma||Disease||
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| Spinal ependymoma||Disease||
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|CBL
| Spinal ependymoma, MYCN-amplified||Disease||
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|NF1
| Myxopapillary ependymoma||Disease||
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|SUZ12
| Subependymoma||Disease||
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|ERG
| Choroid plexus papilloma||Disease||
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|EST2
| Atypical choroid plexus papilloma||Disease||
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|RPS14
| Choroid plexus carcinoma||Disease||
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|RB1
| Medulloblastoma, WNT-activated||Disease||
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|MPL
| Medulloblastoma, SHH-activated and TP53-wildtype||Disease||
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|CHGA
| Medulloblastoma, SHH-activated and TP53-mutant||Disease||
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|CDH1
| Medulloblastoma, non-WNT/non-SHH||Disease||
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|SRSF2
| Medulloblastoma, histologically defined||Disease||
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|DNMT1
| Atypical teratoid/rhabdoid tumour||Disease||
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|PRDX2
| Cribriform neuroepithelial tumour||Disease||
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| Embryonal tumour with multilayered rosettes||Disease||
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|MN1
| CNS neuroblastoma, FOXR2-activated||Disease||
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|SF3A1
| CNS tumour with BCOR internal tandem duplication||Disease||
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|EP300
| CNS embryonal tumour NEC/NOS||Disease||
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|JARID2
| Pineocytoma||Disease||
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|BRCA1
| Pineal parenchymal tumour of intermediate differentiation||Disease||
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|BRCA2
| Pineoblastoma||Disease||
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| Papillary tumour of the pineal region||Disease||
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| Desmoplastic myxoid tumour of the pineal region, SMARCB1-mutant||Disease||
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| Schwannoma||Disease||
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|Oligodendroglioma, IDH-mutant and 1p/19q-codeleted||Disease||
| Neurofibroma||Disease||
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|Diffuse astrocytoma, MYB- or MYBL1-altered||Disease||
| Perineurioma||Disease||
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|Polymorphous low-grade neuroepithelial tumour of the young||Disease||
| Hybrid nerve sheath tumours||Disease||
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|Diffuse midline glioma, H3 K27-altered||Disease||
| Malignant melanotic nerve sheath tumour||Disease||
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|Diffuse paediatric-type high-grade glioma, H3-wildtype and IDH-wildtype||Disease||
| Malignant peripheral nerve sheath tumour||Disease||
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|Pilocytic astrocytoma||Disease||
| Cauda equina neuroendocrine tumour (previously paraganglioma)||Disease||
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|Pleomorphic xanthoastrocytoma||Disease||
| Meningioma||Disease||
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|Chordoid glioma||Disease||
| Solitary fibrous tumour||Disease||
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|Ganglioglioma||Disease||
| Haemangiomas and vascular malformations||Disease||
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|Desmoplastic infantile ganglioglioma / desmoplastic infantile astrocytoma||Disease||
| Haemangioblastoma||Disease||
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|Diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters||Disease||
| Rhabdomyosarcoma||Disease||
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|Rosette-forming glioneuronal tumour||Disease||
| Intracranial mesenchymal tumour, FET::CREB fusion-positive||Disease||
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|Diffuse leptomeningeal glioneuronal tumour||Disease||
| CIC-rearranged sarcoma||Disease||
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|Dysplastic cerebellar gangliocytoma (Lhermitte-Duclos disease)||Disease||
| Primary intracranial sarcoma, DICER1-mutant||Disease||
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|Extraventricular neurocytoma||Disease||
| Ewing sarcoma||Disease||
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|Supratentorial ependymoma||Disease||
| Mesenchymal chondrosarcoma||Disease||
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|Supratentorial ependymoma, YAP1 fusion-positive||Disease||
| Chondrosarcoma||Disease||
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|Posterior fossa group A (PFA) ependymoma||Disease||
| Chordoma||Disease||
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|Spinal ependymoma||Disease||
| Diffuse meningeal melanocytic neoplasms: Melanocytosis and melanomatosis||Disease||
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|Myxopapillary ependymoma||Disease||
| Circumscribed meningeal melanocytic neoplasms: Melanocytoma and melanoma||Disease||
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|Choroid plexus papilloma||Disease||
| Primary diffuse large B-cell lymphoma of the CNS||Disease||
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|Choroid plexus carcinoma||Disease||
| Immunodeficiency-associated CNS lymphomas||Disease||
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|Medulloblastoma, SHH-activated and TP53-wildtype||Disease||
| Lymphomatoid granulomatosis||Disease||
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|Medulloblastoma, non-WNT/non-SHH||Disease||
| Intravascular large B-cell lymphoma||Disease||
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|Atypical teratoid/rhabdoid tumour||Disease||
| MALT lymphoma of the dura||Disease||
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|Embryonal tumour with multilayered rosettes||Disease||
| Other low-grade B-cell lymphomas of the CNS||Disease||
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|CNS tumour with BCOR internal tandem duplication||Disease||
| Anaplastic large cell lymphoma (ALK+/ALK−)||Disease||
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|Pineocytoma||Disease||
| T-cell and NK/T-cell lymphomas||Disease||
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|Pineoblastoma||Disease||
| Erdheim-Chester disease||Disease||
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|Desmoplastic myxoid tumour of the pineal region, SMARCB1-mutant||Disease||
| Rosai-Dorfman disease||Disease||
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|Neurofibroma||Disease||
| Juvenile xanthogranuloma||Disease||
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|Hybrid nerve sheath tumours||Disease||
| Langerhans cell histiocytosis||Disease||
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|Malignant peripheral nerve sheath tumour||Disease||
| Histiocytic sarcoma||Disease||
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|Meningioma||Disease||
| Germ cell tumours of the CNS||Disease||
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|Haemangiomas and vascular malformations||Disease||
| Adamantinomatous craniopharyngioma||Disease||
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|Rhabdomyosarcoma||Disease||
| Papillary craniopharyngioma||Disease||
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|CIC-rearranged sarcoma||Disease||
| Pituicytoma, granular cell tumour of the sellar region, and spindle cell oncocytoma||Disease||
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|Ewing sarcoma||Disease||
| Pituitary adenoma / pituitary neuroendocrine tumour||Disease||
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|Chondrosarcoma||Disease||
| Pituitary blastoma||Disease||
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|Diffuse meningeal melanocytic neoplasms: Melanocytosis and melanomatosis||Disease||
| Metastases to the brain and spinal cord parenchyma||Disease||
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|Primary diffuse large B-cell lymphoma of the CNS||Disease||
| Metastases to the meninges||Disease||
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|Lymphomatoid granulomatosis||Disease||
| Neurofibromatosis type 1||Disease||
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|MALT lymphoma of the dura||Disease||
| Neurofibromatosis type 2||Disease||
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|Anaplastic large cell lymphoma (ALK+/ALK−)||Disease||
| Schwannomatosis||Disease||
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|Erdheim-Chester disease||Disease||
| Von Hippel-Lindau syndrome||Disease||
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|Juvenile xanthogranuloma||Disease||
| Tuberous sclerosis||Disease||
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|Histiocytic sarcoma||Disease||
| Li-Fraumeni syndrome||Disease||
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|Adamantinomatous craniopharyngioma||Disease||
| Cowden syndrome||Disease||
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|Pituicytoma, granular cell tumour of the sellar region, and spindle cell oncocytoma||Disease||
| Constitutional mismatch repair deficiency syndrome||Disease||
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|Pituitary blastoma||Disease||
| Familial adenomatous polyposis 1||Disease||
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|Metastases to the meninges||Disease||
| Naevoid basal cell carcinoma syndrome||Disease||
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|Neurofibromatosis type 2||Disease||
| Rhabdoid tumour predisposition syndrome||Disease||
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|Von Hippel-Lindau syndrome||Disease||
| Carney complex||Disease||
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|Li-Fraumeni syndrome||Disease||
| DICER1 syndrome||Disease||
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|Constitutional mismatch repair deficiency syndrome||Disease||
| Familial paraganglioma syndromes||Disease||
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|Naevoid basal cell carcinoma syndrome||Disease||
| Melanoma-astrocytoma syndrome||Disease||
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|Carney complex||Disease||
| Familial retinoblastoma||Disease||
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|Familial paraganglioma syndromes||Disease||
| BAP1 tumour predisposition syndrome||Disease||
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|Familial retinoblastoma||Disease||
| Fanconi anaemia||Disease||
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|Fanconi anaemia||Disease||
| ELP1-medulloblastoma syndrome||Disease||
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}