Compendium of Cancer Genome Aberrations

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==[[Forewords and Introductions]]==
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    - [[General Introduction]]
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    - [[ICCR datasets: Haemopoietic]]
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==[[Myeloid proliferations and neoplasms]]==
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*[[Myeloid precursor lesions]]
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  ''italic'' [[Clonal Haematopoiesis]]
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    - [[Introduction]]
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    - [[Clonal haematopoiesis]]
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    - [[Clonal cytopenias of undetermined significance]]
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*[[Myeloproliferative neoplasms]]
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  ''italic''[[Myeloproliferative neoplasms]]
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    - [[Introduction]]
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    - [[Chronic myeloid leukaemia]]
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    - [[Chronic neutrophilic leukaemia]]
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    - [[Chronic eosinophilic leukaemia]]
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    - [[Polycythaemia vera]]
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    - [[Essential thrombocythaemia]]
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    - [[Primary myelofibrosis]]
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    - [[Juvenile myelomonocytic leukaemia]]
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    - [[Myeloproliferative neoplasm, NOS]]
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*[[Mastocytosis]]
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    - [[Introduction]]
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    - [[Cutaneous mastocytosis]]
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    - [[Systemic mastocytosis]]
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    - [[Mast cell sarcoma]]
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*[[Myelodysplastic neoplasms]]
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    - [[Introduction]]
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  ''italic''[[Myelodysplastic neoplasms, with defining genetic abnormalities]]
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    - [[Myelodysplastic neoplasm with low blasts and 5q deletion]]
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    - [[Myelodysplastic neoplasm with low blasts and SF3B1 mutation]]
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    - [[Myelodysplastic neoplasm with biallelic TP53 inactivation]]
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  ''italic''[[Myelodysplastic neoplasms, morphologically defined]]
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    - [[Myelodysplastic neoplasm with low blasts]]
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    - [[Myelodysplastic neoplasm, hypoplastic]]
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    - [[Myelodysplastic neoplasm with increased blasts]]
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  ''italic''[[Myelodysplastic neoplasms of childhood]]
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    - [[Childhood myelodysplastic neoplasm with low blasts]]
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    - [[Childhood myelodysplastic neoplasm with increased blasts]]
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*[[Myelodysplastic/myeloproliferative neoplasms]]
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    - [[Introduction]]
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    - [[Chronic myelomonocytic leukaemia]]
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    - [[Myelodysplastic/myeloproliferative neoplasm with neutrophilia]]
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    - [[Myelodysplastic/myeloproliferative neoplasm with SF3B1 mutation and thrombocytosis]]
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    - [[Myelodysplastic/myeloproliferative neoplasm, NOS]]
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*[[Acute myeloid leukaemia]]
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    - [[Introduction]]
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  ''italic''[[Acute myeloid leukaemia with defining genetic abnormalities]]
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    - [[Acute promyelocytic leukaemia with PML::RARA fusion]]
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    - [[Acute myeloid leukaemia with RUNX1::RUNX1T1 fusion]]
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    - [[Acute myeloid leukaemia with CBFB::MYH11 fusion]]
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    - [[Acute myeloid leukaemia with DEK::NUP214 fusion]]
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    - [[Acute myeloid leukaemia with RBM15::MRTFA fusion]]
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    - [[Acute myeloid leukaemia with BCR::ABL1 fusion]]
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    - [[Acute myeloid leukaemia with KMT2A rearrangement]]
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    - [[Acute myeloid leukaemia with MECOM rearrangement]]
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    - [[Acute myeloid leukaemia with NUP98 rearrangement]]
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    - [[Acute myeloid leukaemia with NPM1 mutation]]
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    - [[Acute myeloid leukaemia with CEBPA mutation]]
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    - [[Acute myeloid leukaemia, myelodysplasia-related]]
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    - [[Acute myeloid leukaemia with other defined genetic alterations]]
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  ''italic''[[Acute myeloid leukaemia, defined by differentiation]]
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    - [[Acute myeloid leukaemia with minimal differentiation]]
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    - [[Acute myeloid leukaemia without maturation]]
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    - [[Acute myeloid leukaemia with maturation]]
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    - [[Acute basophilic leukaemia]]
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    - [[Acute myelomonocytic leukaemia]]
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    - [[Acute monocytic leukaemia]]
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    - [[Acute erythroid leukaemia]]
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    - [[Acute megakaryoblastic leukaemia]]
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  ''italic''[[Myeloid sarcoma]]
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    - [[Myeloid sarcoma]]
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*[[Myeloid neoplasms, secondary]]
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  ''italic''[[Myeloid neoplasms and proliferations associated with antecedent or predisposing conditions]]
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    - [[Introduction]]
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    - [[Myeloid neoplasm post cytotoxic therapy]]
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    - [[Myeloid neoplasms associated with germline predisposition]]
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    - [[Myeloid proliferations associated with Down syndrome]]
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*[[Myeloid/lymphoid neoplasms]]
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  ''italic''[[Myeloid/lymphoid neoplasms with eosinophilia and defining gene rearrangement]]
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    - [[Introduction]]
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    - [[Myeloid/lymphoid neoplasm with PDGFRA rearrangement]]
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    - [[Myeloid/lymphoid neoplasm with PDGFRB rearrangement]]
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    - [[Myeloid/lymphoid neoplasm with FGFR1 rearrangement]]
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    - [[Myeloid/lymphoid neoplasm with JAK2 rearrangement]]
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    - [[Myeloid/lymphoid neoplasm with FLT3 rearrangement]]
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    - [[Myeloid/lymphoid neoplasm with ETV6::ABL1 fusion]]
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    - [[Myeloid/lymphoid neoplasms with other tyrosine kinase fusion genes]]
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*[[Acute leukaemias of mixed or ambiguous lineage]]
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    - [[Introduction]]
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  ''italic''[[Acute leukaemia of ambiguous lineage with defining genetic abnormalities]]
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    - [[Mixed-phenotype acute leukaemia with BCR::ABL1 fusion]]
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    - [[Mixed-phenotype acute leukaemia with KMT2A rearrangement]]
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    - [[Acute leukaemia of ambiguous lineage with other defined genetic alterations ]]
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  ''italic''[[Acute leukaemia of ambiguous lineage, immunophenotypically defined]]
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    - [[Mixed-phenotype acute leukaemia, B/myeloid]]
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    - [[Mixed-phenotype acute leukaemia, T/myeloid]]
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    - [[Mixed-phenotype acute leukaemia, rare types]]
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    - [[Acute leukaemia of ambiguous lineage, NOS]]
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    - [[Acute undifferentiated leukaemia]]
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==[[Histiocytic/Dendritic cell neoplasms]]==
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    - [[Introduction]]
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*[[Plasmacytoid dendritic cell neoplasms]]
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  ''italic''[[Plasmacytoid dendritic cell neoplasms]]
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    - [[Mature plasmacytoid dendritic cell proliferation associated with myeloid neoplasm]]
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    - [[Blastic plasmacytoid dendritic cell neoplasm]]
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*[[Langerhans cell and other dendritic cell neoplasms]]
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  ''italic''[[Langerhans cells neoplasms]]
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    - [[Langerhans cell histiocytosis]]
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    - [[Langerhans cell sarcoma]]
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  ''italic''[[Other dendritic cell neoplasms]]
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    - [[Indeterminate dendritic cell tumour]]
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    - [[Interdigitating dendritic cell sarcoma]]
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*[[Histiocyte/macrophage neoplasms]]
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  ''italic''[[Histiocytic neoplasms]]
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    - [[Juvenile xanthogranuloma]]
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    - [[Erdheim-Chester disease]]
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    - [[Rosai-Dorfman Disease]]
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    - [[ALK-positive histiocytosis]]
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    - [[Histiocytic sarcoma]]
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==[[B-cell lymphoid proliferations and lymphomas]]==
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    - [[Introduction to B-cell lymphoproliferative disorders and neoplasms]]
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*[[Tumour like lesions with B-cell predominance]]
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    - [[Introduction]]
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    - [[Reactive B-cell rich lymphoid proliferations that can mimic lymphoma]]
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    - [[IgG4-related disease]]
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    - [[Unicentric Castleman disease]]
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    - [[Idiopathic multicentric Castleman disease]]
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    - [[KSHV/HHV8-associated multicentric Castleman disease]]
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*[[Precursor B-cell neoplasms]]
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  ''italic''[[B-lymphoblastic leukaemias/lymphomas]]
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    - [[Introduction]]
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    - [[B-lymphoblastic leukaemia/lymphoma]]
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    - [[B-lymphoblastic leukaemia/lymphoma with high hyperdiploidy]]
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    - [[B-lymphoblastic leukaemia/lymphoma with hypodiploidy]]
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    - [[B-lymphoblastic leukaemia/lymphoma with iAMP21]]
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    - [[B-lymphoblastic leukaemia/lymphoma with BCR::ABL1 fusion]]
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    - [[B-lymphoblastic leukaemia/lymphoma with BCR::ABL1-like features]]
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    - [[B lymphoblastic leukaemia/lymphoma with KMT2A rearrangement]]
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    - [[B lymphoblastic leukaemia/lymphoma with ETV6::RUNX1 fusion]]
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    - [[B-lymphoblastic leukaemia/lymphoma with ETV6::RUNX1-like features]]
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    - [[B lymphoblastic leukaemia/lymphoma with TCF3::PBX1 fusion]]
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    - [[B lymphoblastic leukaemia/lymphoma with IGH::IL3 fusion ]]
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    - [[B lymphoblastic leukaemia/lymphoma with TCF3::HLF fusion]]
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    - [[B-lymphoblastic leukaemia/lymphoma with other defined genetic alterations]]
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    - [[B-lymphoblastic leukaemia/lymphoma, NOS]]
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*[[Mature B-cell neoplasms]]
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  ''italic''[[Pre-neoplastic and neoplastic small lymphocytic proliferations ]]
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    - [[Introduction]]
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    - [[Monoclonal B-cell lymphocytosis]]
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    - [[Chronic lymphocytic leukaemia/small lymphocytic lymphoma]]
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  ''italic''[[Splenic B-cell lymphomas and leukaemias]]
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    - [[Introduction]]
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    - [[Hairy cell leukaemia]]
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    - [[Splenic marginal zone lymphoma]]
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    - [[Splenic diffuse red pulp small B-cell lymphoma]]
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    - [[Splenic B-cell lymphoma/leukaemia with prominent nucleoli]]
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  ''italic''[[Lymphoplasmacytic lymphoma]]
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    - [[Lymphoplasmacytic lymphoma]]
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  ''italic''[[Marginal zone lymphoma]]
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    - [[Introduction]]
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    - [[Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue]]
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    - [[Primary cutaneous marginal zone lymphoma ]]
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    - [[Nodal marginal zone lymphoma]]
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    - [[Paediatric nodal marginal zone lymphoma]]
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  ''italic''[[Follicular lymphoma]]
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    - [[Introduction]]
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    - [[In situ follicular B-cell neoplasm]]
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    - [[Follicular lymphoma]]
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    - [[Paediatric-type follicular lymphoma]]
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    - [[Duodenal-type follicular lymphoma]]
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  ''italic''[[Cutaneous follicle centre lymphoma]]
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    - [[Primary cutaneous follicle centre lymphoma]]
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  ''italic''[[Mantle cell lymphoma]]
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    - [[Introduction]]
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    - [[In situ mantle cell neoplasm]]
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    - [[Mantle cell lymphoma]]
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    - [[Leukaemic non-nodal mantle cell lymphoma]]
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  ''italic''[[Transformations of indolent B-cell lymphomas]]
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    - [[Introduction]]
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    - [[Transformations of indolent B-cell lymphomas]]
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  ''italic''[[Large B-cell lymphomas]]
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    - [[Introduction]]
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    - [[Diffuse large B-cell lymphoma, NOS]]
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    - [[T-cell/histiocyte-rich large B-cell lymphoma]]
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    - [[Diffuse large B-cell lymphoma / high grade B-cell lymphoma with MYC and BCL2 rearrangements]]
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    - [[ALK-positive large B-cell lymphoma]]
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    - [[Large B-cell lymphoma with IRF4 rearrangement]]
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    - [[High grade B-cell lymphoma with 11q aberrations]]
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    - [[Lymphomatoid granulomatosis]]
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    - [[EBV-positive diffuse large B-cell lymphoma]]
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    - [[Diffuse large B-cell lymphoma associated with chronic inflammation]]
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    - [[Fibrin-associated large B-cell lymphoma]]
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    - [[Fluid overload-associated large B-cell lymphoma]]
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    - [[Plasmablastic lymphoma]]
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    - [[Primary large B-cell lymphoma of immune-privileged sites]]
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    - [[Primary cutaneous diffuse large B-cell lymphoma, leg type]]
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    - [[Intravascular large B-cell lymphoma]]
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    - [[Primary mediastinal large B-cell lymphoma]]
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    - [[Mediastinal grey zone lymphoma]]
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    - [[High-grade B-cell lymphoma, NOS]]
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  ''italic''[[Burkitt lymphoma]]
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    - [[Burkitt lymphoma]]
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  ''italic''[[KSHV/HHV8-associated B-cell lymphoid proliferations and lymphomas]]
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    - [[Introduction]]
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    - [[Primary effusion lymphoma]]
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    - [[KSHV/HHV8-positive diffuse large B-cell lymphoma]]
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    - [[KSHV/HHV8-positive germinotropic lymphoproliferative disorder]]
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  ''italic''[[Lymphoid proliferations and lymphomas associated with immune deficiency and dysregulation]]
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    - [[Introduction]]
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    - [[Hyperplasias arising in immune deficiency/dysregulation]]
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    - [[Polymorphic lymphoproliferative disorders arising in immune deficiency / dysregulation ]]
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    - [[EBV-positive mucocutaneous ulcer]]
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    - [[Lymphomas arising in immune deficiency / dysregulation ]]
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    - [[Inborn error of immunity-associated lymphoid proliferations and lymphomas]]
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*[[Hodgkin lymphoma]]
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    - [[Introduction]]
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    - [[Classic Hodgkin lymphoma ]]
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    - [[Nodular lymphocyte predominant Hodgkin lymphoma]]
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*[[Plasma cell neoplasms and other diseases with paraproteins]]
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    - [[Introduction]]
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  ''italic''[[Monoclonal gammopathies]]
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    - [[Cold agglutinin disease ]]
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    - [[IgM monoclonal gammopathy of undetermined significance]]
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    - [[Non-IgM monoclonal gammopathy of undetermined significance]]
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    - [[Monoclonal gammopathy of renal significance]]
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  ''italic''[[Diseases with monoclonal immunoglobulin deposition]]
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    - [[Immunoglobulin-related (AL) amyloidosis]]
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    - [[Monoclonal immunoglobulin deposition disease]]
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  ''italic''[[Heavy chain diseases]]
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    - [[Introduction]]
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    - [[Mu heavy chain disease]]
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    - [[Gamma heavy chain disease]]
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    - [[Alpha heavy chain disease]]
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  ''italic''[[Plasma cell neoplasms]]
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    - [[Introduction]]
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    - [[Plasmacytoma]]
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    - [[Plasma cell myeloma / multiple myeloma]]
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    - [[Plasma cell neoplasms with associated paraneoplastic syndrome]]
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==[[T-cell and NK-cell lymphoid proliferations and lymphomas ]]==
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    - [[Introduction]]
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*[[Tumour-like lesions with T-cell predominance]]
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    - [[Kikuchi-Fujimoto disease]]
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    - [[Autoimmune lymphoproliferative syndrome]]
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    - [[Indolent T-lymphoblastic proliferation]]
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*[[Precursor T-cell neoplasms]]
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  ''italic''[[T-lymphoblastic leukaemia / lymphoma]]
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    - [[T-lymphoblastic leukaemia / lymphoma, NOS]]
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    - [[Early T-precursor lymphoblastic leukaemia / lymphoma ]]
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*[[Mature T-cell and NK-cell neoplasms]]
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  ''italic''[[Mature T-cell and NK-cell leukaemias]]
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    - [[Introduction]]
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    - [[T-prolymphocytic leukaemia]]
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    - [[T-large granular lymphocytic leukaemia]]
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    - [[NK-large granular lymphocytic leukaemia]]
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    - [[Adult T-cell leukaemia/lymphoma]]
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    - [[Sezary syndrome]]
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    - [[Aggressive NK-cell leukaemia]]
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  ''italic''[[Primary cutaneous T-cell lymphoid proliferations and lymphomas]]
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    - [[Introduction to primary cutaneous T-cell neoplasms]]
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    - [[Primary cutaneous CD4-positive small or medium T-cell lymphoproliferative disorder]]
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    - [[Primary cutaneous acral CD8-positive T-cell lymphoproliferative disorder]]
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    - [[Mycosis fungoides]]
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    - [[Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Lymphomatoid papulosis]]
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    - [[Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Primary cutaneous anaplastic large cell lymphoma]]
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    - [[Subcutaneous panniculitis-like T-cell lymphoma]]
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    - [[Primary cutaneous gamma/delta T-cell lymphoma]]
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    - [[Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma]]
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    - [[Primary cutaneous peripheral T-cell lymphoma, NOS]]
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  ''italic''[[Intestinal T-cell and NK-cell lymphoid proliferations and lymphomas]]
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    - [[Introduction]]
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    - [[Indolent T-cell lymphoma of the gastrointestinal tract]]
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    - [[Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract]]
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    - [[Enteropathy-associated T-cell lymphoma]]
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    - [[Monomorphic epitheliotropic intestinal T-cell lymphoma]]
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    - [[Intestinal T-cell lymphoma, NOS]]
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  ''italic''[[Hepatosplenic T-cell lymphoma]]
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    - [[Hepatosplenic T-cell lymphoma]]
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  ''italic''[[Anaplastic large cell lymphoma]]
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    - [[Introduction]]
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    - [[ALK-positive anaplastic large cell lymphoma]]
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    - [[ALK-negative anaplastic large cell lymphoma]]
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    - [[Breast implant-associated anaplastic large cell lymphoma]]
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  ''italic''[[Nodal T-follicular helper (TFH) cell lymphoma]]
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    - [[Introduction]]
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    - [[Nodal TFH cell lymphoma, angioimmunoblastic-type]]
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    - [[Nodal TFH cell lymphoma, follicular-type]]
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    - [[Nodal TFH cell lymphoma, NOS]]
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  ''italic''[[Other peripheral T-cell lymphomas]]
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    - [[Peripheral T-cell lymphoma, NOS]]
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  ''italic''[[EBV-positive NK-cell and T-cell lymphomas]]
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    - [[EBV-positive nodal T- and NK-cell lymphoma]]
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    - [[Extranodal NK/T-cell lymphoma]]
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  ''italic''[[EBV-positive T-cell and NK-cell lymphoid proliferations and lymphomas of childhood]]
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    - [[Introduction]]
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    - [[Severe mosquito bite allergy]]
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    - [[Hydroa vacciniforme lymphoproliferative disorder]]
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    - [[Systemic chronic active EBV disease]]
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    - [[Systemic EBV-positive T-cell lymphoma of childhood]]
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==[[Stroma-derived neoplasms of lymphoid tissues]]==
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    - [[Introduction]]
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*[[Mesenchymal dendritic cell neoplasms]]
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  ''italic''[[Follicular dendritic cell neoplasms]]
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    - [[Follicular dendritic cell sarcoma]]
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    - [[EBV-positive inflammatory follicular dendritic cell sarcoma]]
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    - [[Fibroblastic reticular cell tumour]]
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*[[Myofibroblastic tumours]]
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  ''italic''[[Myofibroblastic tumour]]
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    - [[Intranodal palisaded myofibroblastoma]]
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*[[Spleen-specific vascular-stromal tumours]]
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  ''italic''[[Splenic vascular-stromal tumours]]
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    - [[Littoral cell angioma]]
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    - [[Splenic hamartoma]]
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    - [[Sclerosing angiomatoid nodular transformation (SANT) of spleen]]
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==[[Genetic tumour syndromes]]==
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    - [[Introduction]]
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    - [[Fanconi anaemia]]
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    - [[Bloom syndrome]]
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    - [[Ataxia-telangiectasia syndrome]]
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    - [[RASopathies]]
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