Compendium of Cancer Genome Aberrations

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==Myeloid proliferations and neoplasms ([[Myeloid proliferations and neoplasms|Overview Page Link]])==
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'''Myeloid precursor lesions'''
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  ''Clonal Haematopoiesis''
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    - [[Clonal haematopoiesis]]
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    - [[Clonal cytopenias of undetermined significance]]
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'''Myeloproliferative neoplasms
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  ''Myeloproliferative neoplasms''
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    - [[Chronic myeloid leukaemia]]
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    - [[Chronic neutrophilic leukaemia]]
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    - [[Chronic eosinophilic leukaemia]]
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    - [[Polycythaemia vera]]
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    - [[Essential thrombocythaemia]]
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    - [[Primary myelofibrosis]]
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    - [[Juvenile myelomonocytic leukaemia]]
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    - [[Myeloproliferative neoplasm, NOS]]
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'''Mastocytosis'''
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    - [[Cutaneous mastocytosis]]
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    - [[Systemic mastocytosis]]
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    - [[Mast cell sarcoma]]
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'''Myelodysplastic neoplasms'''
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  ''Myelodysplastic neoplasms, with defining genetic abnormalities''
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    - [[Myelodysplastic neoplasm with low blasts and 5q deletion]]
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    - [[Myelodysplastic neoplasm with low blasts and SF3B1 mutation]]
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    - [[Myelodysplastic neoplasm with biallelic TP53 inactivation]]
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  ''Myelodysplastic neoplasms, morphologically defined''
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    - [[Myelodysplastic neoplasm with low blasts]]
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    - [[Myelodysplastic neoplasm, hypoplastic]]
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    - [[Myelodysplastic neoplasm with increased blasts]]
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  ''Myelodysplastic neoplasms of childhood''
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    - [[Childhood myelodysplastic neoplasm with low blasts]]
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    - [[Childhood myelodysplastic neoplasm with increased blasts]]
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'''Myelodysplastic/myeloproliferative neoplasms'''
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    - [[Chronic myelomonocytic leukaemia]]
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    - [[Myelodysplastic/myeloproliferative neoplasm with neutrophilia]]
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    - [[Myelodysplastic/myeloproliferative neoplasm with SF3B1 mutation and thrombocytosis]]
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    - [[Myelodysplastic/myeloproliferative neoplasm, NOS]]
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'''Acute myeloid leukaemia'''
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  ''Acute myeloid leukaemia with defining genetic abnormalities''
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    - [[Acute promyelocytic leukaemia with PML::RARA fusion]]
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    - [[Acute myeloid leukaemia with RUNX1::RUNX1T1 fusion]]
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    - [[Acute myeloid leukaemia with CBFB::MYH11 fusion]]
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    - [[Acute myeloid leukaemia with DEK::NUP214 fusion]]
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    - [[Acute myeloid leukaemia with RBM15::MRTFA fusion]]
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    - [[Acute myeloid leukaemia with BCR::ABL1 fusion]]
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    - [[Acute myeloid leukaemia with KMT2A rearrangement]]
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    - [[Acute myeloid leukaemia with MECOM rearrangement]]
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    - [[Acute myeloid leukaemia with NUP98 rearrangement]]
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    - [[Acute myeloid leukaemia with NPM1 mutation]]
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    - [[Acute myeloid leukaemia with CEBPA mutation]]
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    - [[Acute myeloid leukaemia, myelodysplasia-related]]
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    - [[Acute myeloid leukaemia with other defined genetic alterations]]
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  ''Acute myeloid leukaemia, defined by differentiation''
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    - [[Acute myeloid leukaemia with minimal differentiation]]
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    - [[Acute myeloid leukaemia without maturation]]
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    - [[Acute myeloid leukaemia with maturation]]
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    - [[Acute basophilic leukaemia]]
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    - [[Acute myelomonocytic leukaemia]]
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    - [[Acute monocytic leukaemia]]
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    - [[Acute erythroid leukaemia]]
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    - [[Acute megakaryoblastic leukaemia]]
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  ''Myeloid sarcoma''
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    - [[Myeloid sarcoma]]
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'''Myeloid neoplasms, secondary'''
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  ''Myeloid neoplasms and proliferations associated with antecedent or predisposing conditions''
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    - [[Myeloid neoplasm post cytotoxic therapy]]
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    - [[Myeloid neoplasms associated with germline predisposition]]
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    - [[Myeloid proliferations associated with Down syndrome]]
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'''Myeloid/lymphoid neoplasms'''
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  ''Myeloid/lymphoid neoplasms with eosinophilia and defining gene rearrangement''
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    - [[Myeloid/lymphoid neoplasm with PDGFRA rearrangement]]
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    - [[Myeloid/lymphoid neoplasm with PDGFRB rearrangement]]
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    - [[Myeloid/lymphoid neoplasm with FGFR1 rearrangement]]
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    - [[Myeloid/lymphoid neoplasm with JAK2 rearrangement]]
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    - [[Myeloid/lymphoid neoplasm with FLT3 rearrangement]]
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    - [[Myeloid/lymphoid neoplasm with ETV6::ABL1 fusion]]
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    - [[Myeloid/lymphoid neoplasms with other tyrosine kinase fusion genes]]
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'''Acute leukaemias of mixed or ambiguous lineage'''
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  ''Acute leukaemia of ambiguous lineage with defining genetic abnormalities''
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    - [[Mixed-phenotype acute leukaemia with BCR::ABL1 fusion]]
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    - [[Mixed-phenotype acute leukaemia with KMT2A rearrangement]]
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    - [[Acute leukaemia of ambiguous lineage with other defined genetic alterations ]]
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  ''Acute leukaemia of ambiguous lineage, immunophenotypically defined''
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    - [[Mixed-phenotype acute leukaemia, B/myeloid]]
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    - [[Mixed-phenotype acute leukaemia, T/myeloid]]
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    - [[Mixed-phenotype acute leukaemia, rare types]]
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    - [[Acute leukaemia of ambiguous lineage, NOS]]
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    - [[Acute undifferentiated leukaemia]]
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==Histiocytic/Dendritic cell neoplasms ([[Histiocytic/Dendritic cell neoplasms|Overview Page Link]])==
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'''Plasmacytoid dendritic cell neoplasms'''
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  ''Plasmacytoid dendritic cell neoplasms''
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    - [[Mature plasmacytoid dendritic cell proliferation associated with myeloid neoplasm]]
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    - [[Blastic plasmacytoid dendritic cell neoplasm]]
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'''Langerhans cell and other dendritic cell neoplasms'''
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  ''Langerhans cells neoplasms''
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    - [[Langerhans cell histiocytosis]]
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    - [[Langerhans cell sarcoma]]
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  ''Other dendritic cell neoplasms''
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    - [[Indeterminate dendritic cell tumour]]
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    - [[Interdigitating dendritic cell sarcoma]]
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'''Histiocyte/macrophage neoplasms'''
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  ''Histiocytic neoplasms''
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    - [[Juvenile xanthogranuloma]]
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    - [[Erdheim-Chester disease]]
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    - [[Rosai-Dorfman Disease]]
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    - [[ALK-positive histiocytosis]]
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    - [[Histiocytic sarcoma]]
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==B-cell lymphoid proliferations and lymphomas ([[B-cell lymphoid proliferations and lymphomas|Overview Page Link]])==
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'''Tumour like lesions with B-cell predominance'''
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    - [[Reactive B-cell rich lymphoid proliferations that can mimic lymphoma]]
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    - [[IgG4-related disease]]
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    - [[Unicentric Castleman disease]]
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    - [[Idiopathic multicentric Castleman disease]]
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    - [[KSHV/HHV8-associated multicentric Castleman disease]]
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'''Precursor B-cell neoplasms'''
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  ''B-lymphoblastic leukaemias/lymphomas''
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    - [[B-lymphoblastic leukaemia/lymphoma]]
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    - [[B-lymphoblastic leukaemia/lymphoma with high hyperdiploidy]]
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    - [[B-lymphoblastic leukaemia/lymphoma with hypodiploidy]]
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    - [[B-lymphoblastic leukaemia/lymphoma with iAMP21]]
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    - [[B-lymphoblastic leukaemia/lymphoma with BCR::ABL1 fusion]]
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    - [[B-lymphoblastic leukaemia/lymphoma with BCR::ABL1-like features]]
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    - [[B lymphoblastic leukaemia/lymphoma with KMT2A rearrangement]]
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    - [[B lymphoblastic leukaemia/lymphoma with ETV6::RUNX1 fusion]]
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    - [[B-lymphoblastic leukaemia/lymphoma with ETV6::RUNX1-like features]]
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    - [[B lymphoblastic leukaemia/lymphoma with TCF3::PBX1 fusion]]
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    - [[B lymphoblastic leukaemia/lymphoma with IGH::IL3 fusion ]]
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    - [[B lymphoblastic leukaemia/lymphoma with TCF3::HLF fusion]]
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    - [[B-lymphoblastic leukaemia/lymphoma with other defined genetic alterations]]
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    - [[B-lymphoblastic leukaemia/lymphoma, NOS]]
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'''Mature B-cell neoplasms'''
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  ''Pre-neoplastic and neoplastic small lymphocytic proliferations ''
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    - [[Monoclonal B-cell lymphocytosis]]
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    - [[Chronic lymphocytic leukaemia/small lymphocytic lymphoma]]
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  ''Splenic B-cell lymphomas and leukaemias''
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    - [[Hairy cell leukaemia]]
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    - [[Splenic marginal zone lymphoma]]
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    - [[Splenic diffuse red pulp small B-cell lymphoma]]
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    - [[Splenic B-cell lymphoma/leukaemia with prominent nucleoli]]
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  ''Lymphoplasmacytic lymphoma''
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    - [[Lymphoplasmacytic lymphoma]]
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  ''Marginal zone lymphoma''
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    - [[Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue]]
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    - [[Primary cutaneous marginal zone lymphoma ]]
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    - [[Nodal marginal zone lymphoma]]
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    - [[Paediatric nodal marginal zone lymphoma]]
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  ''Follicular lymphoma''
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    - [[In situ follicular B-cell neoplasm]]
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    - [[Follicular lymphoma]]
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    - [[Paediatric-type follicular lymphoma]]
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    - [[Duodenal-type follicular lymphoma]]
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  ''Cutaneous follicle centre lymphoma''
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    - [[Primary cutaneous follicle centre lymphoma]]
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  ''Mantle cell lymphoma''
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    - [[In situ mantle cell neoplasm]]
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    - [[Mantle cell lymphoma]]
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    - [[Leukaemic non-nodal mantle cell lymphoma]]
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  ''Transformations of indolent B-cell lymphomas''
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    - [[Transformations of indolent B-cell lymphomas]]
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  ''Large B-cell lymphomas''
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    - [[Diffuse large B-cell lymphoma, NOS]]
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    - [[T-cell/histiocyte-rich large B-cell lymphoma]]
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    - [[Diffuse large B-cell lymphoma / high grade B-cell lymphoma with MYC and BCL2 rearrangements]]
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    - [[ALK-positive large B-cell lymphoma]]
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    - [[Large B-cell lymphoma with IRF4 rearrangement]]
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    - [[High grade B-cell lymphoma with 11q aberrations]]
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    - [[Lymphomatoid granulomatosis]]
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    - [[EBV-positive diffuse large B-cell lymphoma]]
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    - [[Diffuse large B-cell lymphoma associated with chronic inflammation]]
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    - [[Fibrin-associated large B-cell lymphoma]]
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    - [[Fluid overload-associated large B-cell lymphoma]]
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    - [[Plasmablastic lymphoma]]
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    - [[Primary large B-cell lymphoma of immune-privileged sites]]
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    - [[Primary cutaneous diffuse large B-cell lymphoma, leg type]]
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    - [[Intravascular large B-cell lymphoma]]
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    - [[Primary mediastinal large B-cell lymphoma]]
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    - [[Mediastinal grey zone lymphoma]]
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    - [[High-grade B-cell lymphoma, NOS]]
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  ''Burkitt lymphoma''
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    - [[Burkitt lymphoma]]
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  ''KSHV/HHV8-associated B-cell lymphoid proliferations and lymphomas''
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    - [[Primary effusion lymphoma]]
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    - [[KSHV/HHV8-positive diffuse large B-cell lymphoma]]
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    - [[KSHV/HHV8-positive germinotropic lymphoproliferative disorder]]
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  ''Lymphoid proliferations and lymphomas associated with immune deficiency and dysregulation''
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    - [[Hyperplasias arising in immune deficiency/dysregulation]]
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    - [[Polymorphic lymphoproliferative disorders arising in immune deficiency / dysregulation ]]
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    - [[EBV-positive mucocutaneous ulcer]]
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    - [[Lymphomas arising in immune deficiency / dysregulation ]]
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    - [[Inborn error of immunity-associated lymphoid proliferations and lymphomas]]
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'''Hodgkin lymphoma'''
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    - [[Classic Hodgkin lymphoma ]]
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    - [[Nodular lymphocyte predominant Hodgkin lymphoma]]
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'''Plasma cell neoplasms and other diseases with paraproteins'''
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  ''Monoclonal gammopathies''
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    - [[Cold agglutinin disease ]]
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    - [[IgM monoclonal gammopathy of undetermined significance]]
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    - [[Non-IgM monoclonal gammopathy of undetermined significance]]
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    - [[Monoclonal gammopathy of renal significance]]
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  ''Diseases with monoclonal immunoglobulin deposition''
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    - [[Immunoglobulin-related (AL) amyloidosis]]
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    - [[Monoclonal immunoglobulin deposition disease]]
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  ''Heavy chain diseases''
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    - [[Mu heavy chain disease]]
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    - [[Gamma heavy chain disease]]
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    - [[Alpha heavy chain disease]]
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  ''Plasma cell neoplasms''
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    - [[HAEM5:Plasmacytoma]]
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    - [[Plasma cell myeloma / multiple myeloma]]
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    - [[Plasma cell neoplasms with associated paraneoplastic syndrome]]
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==T-cell and NK-cell lymphoid proliferations and lymphomas  ([[T-cell and NK-cell lymphoid proliferations and lymphomas |Overview Page Link]])==
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'''Tumour-like lesions with T-cell predominance'''
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    - [[Kikuchi-Fujimoto disease]]
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    - [[Autoimmune lymphoproliferative syndrome]]
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    - [[Indolent T-lymphoblastic proliferation]]
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'''Precursor T-cell neoplasms'''
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  ''T-lymphoblastic leukaemia / lymphoma''
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    - [[T-lymphoblastic leukaemia / lymphoma, NOS]]
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    - [[Early T-precursor lymphoblastic leukaemia / lymphoma ]]
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'''Mature T-cell and NK-cell neoplasms'''
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  ''Mature T-cell and NK-cell leukaemias''
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    - [[T-prolymphocytic leukaemia]]
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    - [[T-large granular lymphocytic leukaemia]]
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    - [[NK-large granular lymphocytic leukaemia]]
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    - [[Adult T-cell leukaemia/lymphoma]]
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    - [[Sezary syndrome]]
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    - [[Aggressive NK-cell leukaemia]]
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  ''Primary cutaneous T-cell lymphoid proliferations and lymphomas''
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    - [[Primary cutaneous CD4-positive small or medium T-cell lymphoproliferative disorder]]
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    - [[Primary cutaneous acral CD8-positive T-cell lymphoproliferative disorder]]
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    - [[Mycosis fungoides]]
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    - [[Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Lymphomatoid papulosis]]
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    - [[Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Primary cutaneous anaplastic large cell lymphoma]]
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    - [[Subcutaneous panniculitis-like T-cell lymphoma]]
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    - [[Primary cutaneous gamma/delta T-cell lymphoma]]
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    - [[Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma]]
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    - [[Primary cutaneous peripheral T-cell lymphoma, NOS]]
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  ''Intestinal T-cell and NK-cell lymphoid proliferations and lymphomas''
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    - [[Indolent T-cell lymphoma of the gastrointestinal tract]]
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    - [[Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract]]
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    - [[Enteropathy-associated T-cell lymphoma]]
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    - [[Monomorphic epitheliotropic intestinal T-cell lymphoma]]
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    - [[Intestinal T-cell lymphoma, NOS]]
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  ''Hepatosplenic T-cell lymphoma''
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    - [[Hepatosplenic T-cell lymphoma]]
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  ''Anaplastic large cell lymphoma''
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    - [[ALK-positive anaplastic large cell lymphoma]]
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    - [[ALK-negative anaplastic large cell lymphoma]]
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    - [[Breast implant-associated anaplastic large cell lymphoma]]
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  ''Nodal T-follicular helper (TFH) cell lymphoma''
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    - [[Nodal TFH cell lymphoma, angioimmunoblastic-type]]
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    - [[Nodal TFH cell lymphoma, follicular-type]]
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    - [[Nodal TFH cell lymphoma, NOS]]
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  ''Other peripheral T-cell lymphomas''
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    - [[Peripheral T-cell lymphoma, NOS]]
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  ''EBV-positive NK-cell and T-cell lymphomas''
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    - [[EBV-positive nodal T- and NK-cell lymphoma]]
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    - [[Extranodal NK/T-cell lymphoma]]
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  ''EBV-positive T-cell and NK-cell lymphoid proliferations and lymphomas of childhood''
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    - [[Severe mosquito bite allergy]]
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    - [[Hydroa vacciniforme lymphoproliferative disorder]]
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    - [[Systemic chronic active EBV disease]]
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    - [[Systemic EBV-positive T-cell lymphoma of childhood]]
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==Stroma-derived neoplasms of lymphoid tissues ([[Stroma-derived neoplasms of lymphoid tissues|Overview Page Link]])==
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'''Mesenchymal dendritic cell neoplasms'''
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  ''Follicular dendritic cell neoplasms''
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    - [[Follicular dendritic cell sarcoma]]
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    - [[EBV-positive inflammatory follicular dendritic cell sarcoma]]
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    - [[Fibroblastic reticular cell tumour]]
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'''Myofibroblastic tumours'''
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  ''Myofibroblastic tumour''
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    - [[Intranodal palisaded myofibroblastoma]]
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'''Spleen-specific vascular-stromal tumours'''
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  ''Splenic vascular-stromal tumours''
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    - [[Littoral cell angioma]]
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    - [[Splenic hamartoma]]
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    - [[Sclerosing angiomatoid nodular transformation (SANT) of spleen]]
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==Genetic tumour syndromes ([[Genetic tumour syndromes|Overview Page Link]])==
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    - [[Fanconi anaemia]]
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    - [[Bloom syndrome]]
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    - [[Ataxia-telangiectasia syndrome]]
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    - [[RASopathies]]
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