Compendium of Cancer Genome Aberrations

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==Forewords and Introductions[[chapter['chapterTitle'|Overview Page Link]]==
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==Myeloid proliferations and neoplasms ([[Myeloid proliferations and neoplasms|Overview Page Link]])==
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    - [[General Introduction]]
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    - [[ICCR datasets: Haemopoietic]]
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'''Myeloid precursor lesions'''
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==Myeloid proliferations and neoplasms[[chapter['chapterTitle'|Overview Page Link]]==
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===Myeloid precursor lesions===
   
   ''Clonal Haematopoiesis''
 
   ''Clonal Haematopoiesis''
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    - [[Introduction]]
   
     - [[Clonal haematopoiesis]]
 
     - [[Clonal haematopoiesis]]
 
     - [[Clonal cytopenias of undetermined significance]]
 
     - [[Clonal cytopenias of undetermined significance]]
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===Myeloproliferative neoplasms===
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'''Myeloproliferative neoplasms
 
   ''Myeloproliferative neoplasms''
 
   ''Myeloproliferative neoplasms''
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    - [[Introduction]]
   
     - [[Chronic myeloid leukaemia]]
 
     - [[Chronic myeloid leukaemia]]
 
     - [[Chronic neutrophilic leukaemia]]
 
     - [[Chronic neutrophilic leukaemia]]
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     - [[Juvenile myelomonocytic leukaemia]]
 
     - [[Juvenile myelomonocytic leukaemia]]
 
     - [[Myeloproliferative neoplasm, NOS]]
 
     - [[Myeloproliferative neoplasm, NOS]]
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===Mastocytosis===
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    - [[Introduction]]
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'''Mastocytosis'''
 
     - [[Cutaneous mastocytosis]]
 
     - [[Cutaneous mastocytosis]]
 
     - [[Systemic mastocytosis]]
 
     - [[Systemic mastocytosis]]
 
     - [[Mast cell sarcoma]]
 
     - [[Mast cell sarcoma]]
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===Myelodysplastic neoplasms===
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    - [[Introduction]]
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'''Myelodysplastic neoplasms'''
 
   ''Myelodysplastic neoplasms, with defining genetic abnormalities''
 
   ''Myelodysplastic neoplasms, with defining genetic abnormalities''
 
     - [[Myelodysplastic neoplasm with low blasts and 5q deletion]]
 
     - [[Myelodysplastic neoplasm with low blasts and 5q deletion]]
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     - [[Childhood myelodysplastic neoplasm with low blasts]]
 
     - [[Childhood myelodysplastic neoplasm with low blasts]]
 
     - [[Childhood myelodysplastic neoplasm with increased blasts]]
 
     - [[Childhood myelodysplastic neoplasm with increased blasts]]
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===Myelodysplastic/myeloproliferative neoplasms===
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    - [[Introduction]]
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'''Myelodysplastic/myeloproliferative neoplasms'''
 
     - [[Chronic myelomonocytic leukaemia]]
 
     - [[Chronic myelomonocytic leukaemia]]
 
     - [[Myelodysplastic/myeloproliferative neoplasm with neutrophilia]]
 
     - [[Myelodysplastic/myeloproliferative neoplasm with neutrophilia]]
 
     - [[Myelodysplastic/myeloproliferative neoplasm with SF3B1 mutation and thrombocytosis]]
 
     - [[Myelodysplastic/myeloproliferative neoplasm with SF3B1 mutation and thrombocytosis]]
 
     - [[Myelodysplastic/myeloproliferative neoplasm, NOS]]
 
     - [[Myelodysplastic/myeloproliferative neoplasm, NOS]]
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===Acute myeloid leukaemia===
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    - [[Introduction]]
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'''Acute myeloid leukaemia'''
 
   ''Acute myeloid leukaemia with defining genetic abnormalities''
 
   ''Acute myeloid leukaemia with defining genetic abnormalities''
 
     - [[Acute promyelocytic leukaemia with PML::RARA fusion]]
 
     - [[Acute promyelocytic leukaemia with PML::RARA fusion]]
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   ''Myeloid sarcoma''
 
   ''Myeloid sarcoma''
 
     - [[Myeloid sarcoma]]
 
     - [[Myeloid sarcoma]]
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===Myeloid neoplasms, secondary===
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'''Myeloid neoplasms, secondary'''
 
   ''Myeloid neoplasms and proliferations associated with antecedent or predisposing conditions''
 
   ''Myeloid neoplasms and proliferations associated with antecedent or predisposing conditions''
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    - [[Introduction]]
   
     - [[Myeloid neoplasm post cytotoxic therapy]]
 
     - [[Myeloid neoplasm post cytotoxic therapy]]
 
     - [[Myeloid neoplasms associated with germline predisposition]]
 
     - [[Myeloid neoplasms associated with germline predisposition]]
 
     - [[Myeloid proliferations associated with Down syndrome]]
 
     - [[Myeloid proliferations associated with Down syndrome]]
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===Myeloid/lymphoid neoplasms===
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'''Myeloid/lymphoid neoplasms'''
 
   ''Myeloid/lymphoid neoplasms with eosinophilia and defining gene rearrangement''
 
   ''Myeloid/lymphoid neoplasms with eosinophilia and defining gene rearrangement''
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    - [[Introduction]]
   
     - [[Myeloid/lymphoid neoplasm with PDGFRA rearrangement]]
 
     - [[Myeloid/lymphoid neoplasm with PDGFRA rearrangement]]
 
     - [[Myeloid/lymphoid neoplasm with PDGFRB rearrangement]]
 
     - [[Myeloid/lymphoid neoplasm with PDGFRB rearrangement]]
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     - [[Myeloid/lymphoid neoplasm with ETV6::ABL1 fusion]]
 
     - [[Myeloid/lymphoid neoplasm with ETV6::ABL1 fusion]]
 
     - [[Myeloid/lymphoid neoplasms with other tyrosine kinase fusion genes]]
 
     - [[Myeloid/lymphoid neoplasms with other tyrosine kinase fusion genes]]
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===Acute leukaemias of mixed or ambiguous lineage===
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    - [[Introduction]]
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'''Acute leukaemias of mixed or ambiguous lineage'''
 
   ''Acute leukaemia of ambiguous lineage with defining genetic abnormalities''
 
   ''Acute leukaemia of ambiguous lineage with defining genetic abnormalities''
 
     - [[Mixed-phenotype acute leukaemia with BCR::ABL1 fusion]]
 
     - [[Mixed-phenotype acute leukaemia with BCR::ABL1 fusion]]
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     - [[Acute leukaemia of ambiguous lineage, NOS]]
 
     - [[Acute leukaemia of ambiguous lineage, NOS]]
 
     - [[Acute undifferentiated leukaemia]]
 
     - [[Acute undifferentiated leukaemia]]
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==Histiocytic/Dendritic cell neoplasms[[chapter['chapterTitle'|Overview Page Link]]==
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==Histiocytic/Dendritic cell neoplasms ([[Histiocytic/Dendritic cell neoplasms|Overview Page Link]])==
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    - [[Introduction]]
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===Plasmacytoid dendritic cell neoplasms===
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'''Plasmacytoid dendritic cell neoplasms'''
 
   ''Plasmacytoid dendritic cell neoplasms''
 
   ''Plasmacytoid dendritic cell neoplasms''
 
     - [[Mature plasmacytoid dendritic cell proliferation associated with myeloid neoplasm]]
 
     - [[Mature plasmacytoid dendritic cell proliferation associated with myeloid neoplasm]]
 
     - [[Blastic plasmacytoid dendritic cell neoplasm]]
 
     - [[Blastic plasmacytoid dendritic cell neoplasm]]
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===Langerhans cell and other dendritic cell neoplasms===
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'''Langerhans cell and other dendritic cell neoplasms'''
 
   ''Langerhans cells neoplasms''
 
   ''Langerhans cells neoplasms''
 
     - [[Langerhans cell histiocytosis]]
 
     - [[Langerhans cell histiocytosis]]
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     - [[Indeterminate dendritic cell tumour]]
 
     - [[Indeterminate dendritic cell tumour]]
 
     - [[Interdigitating dendritic cell sarcoma]]
 
     - [[Interdigitating dendritic cell sarcoma]]
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===Histiocyte/macrophage neoplasms===
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'''Histiocyte/macrophage neoplasms'''
 
   ''Histiocytic neoplasms''
 
   ''Histiocytic neoplasms''
 
     - [[Juvenile xanthogranuloma]]
 
     - [[Juvenile xanthogranuloma]]
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     - [[ALK-positive histiocytosis]]
 
     - [[ALK-positive histiocytosis]]
 
     - [[Histiocytic sarcoma]]
 
     - [[Histiocytic sarcoma]]
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==B-cell lymphoid proliferations and lymphomas[[chapter['chapterTitle'|Overview Page Link]]==
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==B-cell lymphoid proliferations and lymphomas ([[B-cell lymphoid proliferations and lymphomas|Overview Page Link]])==
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    - [[Introduction to B-cell lymphoproliferative disorders and neoplasms]]
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===Tumour like lesions with B-cell predominance===
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'''Tumour like lesions with B-cell predominance'''
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    - [[Introduction]]
   
     - [[Reactive B-cell rich lymphoid proliferations that can mimic lymphoma]]
 
     - [[Reactive B-cell rich lymphoid proliferations that can mimic lymphoma]]
 
     - [[IgG4-related disease]]
 
     - [[IgG4-related disease]]
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     - [[Idiopathic multicentric Castleman disease]]
 
     - [[Idiopathic multicentric Castleman disease]]
 
     - [[KSHV/HHV8-associated multicentric Castleman disease]]
 
     - [[KSHV/HHV8-associated multicentric Castleman disease]]
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===Precursor B-cell neoplasms===
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'''Precursor B-cell neoplasms'''
 
   ''B-lymphoblastic leukaemias/lymphomas''
 
   ''B-lymphoblastic leukaemias/lymphomas''
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    - [[Introduction]]
   
     - [[B-lymphoblastic leukaemia/lymphoma]]
 
     - [[B-lymphoblastic leukaemia/lymphoma]]
 
     - [[B-lymphoblastic leukaemia/lymphoma with high hyperdiploidy]]
 
     - [[B-lymphoblastic leukaemia/lymphoma with high hyperdiploidy]]
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     - [[B-lymphoblastic leukaemia/lymphoma with other defined genetic alterations]]
 
     - [[B-lymphoblastic leukaemia/lymphoma with other defined genetic alterations]]
 
     - [[B-lymphoblastic leukaemia/lymphoma, NOS]]
 
     - [[B-lymphoblastic leukaemia/lymphoma, NOS]]
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===Mature B-cell neoplasms===
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'''Mature B-cell neoplasms'''
 
   ''Pre-neoplastic and neoplastic small lymphocytic proliferations ''
 
   ''Pre-neoplastic and neoplastic small lymphocytic proliferations ''
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    - [[Introduction]]
   
     - [[Monoclonal B-cell lymphocytosis]]
 
     - [[Monoclonal B-cell lymphocytosis]]
 
     - [[Chronic lymphocytic leukaemia/small lymphocytic lymphoma]]
 
     - [[Chronic lymphocytic leukaemia/small lymphocytic lymphoma]]
 
   ''Splenic B-cell lymphomas and leukaemias''
 
   ''Splenic B-cell lymphomas and leukaemias''
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    - [[Introduction]]
   
     - [[Hairy cell leukaemia]]
 
     - [[Hairy cell leukaemia]]
 
     - [[Splenic marginal zone lymphoma]]
 
     - [[Splenic marginal zone lymphoma]]
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     - [[Lymphoplasmacytic lymphoma]]
 
     - [[Lymphoplasmacytic lymphoma]]
 
   ''Marginal zone lymphoma''
 
   ''Marginal zone lymphoma''
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    - [[Introduction]]
   
     - [[Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue]]
 
     - [[Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue]]
 
     - [[Primary cutaneous marginal zone lymphoma ]]
 
     - [[Primary cutaneous marginal zone lymphoma ]]
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     - [[Paediatric nodal marginal zone lymphoma]]
 
     - [[Paediatric nodal marginal zone lymphoma]]
 
   ''Follicular lymphoma''
 
   ''Follicular lymphoma''
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    - [[Introduction]]
   
     - [[In situ follicular B-cell neoplasm]]
 
     - [[In situ follicular B-cell neoplasm]]
 
     - [[Follicular lymphoma]]
 
     - [[Follicular lymphoma]]
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     - [[Primary cutaneous follicle centre lymphoma]]
 
     - [[Primary cutaneous follicle centre lymphoma]]
 
   ''Mantle cell lymphoma''
 
   ''Mantle cell lymphoma''
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    - [[Introduction]]
   
     - [[In situ mantle cell neoplasm]]
 
     - [[In situ mantle cell neoplasm]]
 
     - [[Mantle cell lymphoma]]
 
     - [[Mantle cell lymphoma]]
 
     - [[Leukaemic non-nodal mantle cell lymphoma]]
 
     - [[Leukaemic non-nodal mantle cell lymphoma]]
 
   ''Transformations of indolent B-cell lymphomas''
 
   ''Transformations of indolent B-cell lymphomas''
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    - [[Introduction]]
   
     - [[Transformations of indolent B-cell lymphomas]]
 
     - [[Transformations of indolent B-cell lymphomas]]
 
   ''Large B-cell lymphomas''
 
   ''Large B-cell lymphomas''
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    - [[Introduction]]
   
     - [[Diffuse large B-cell lymphoma, NOS]]
 
     - [[Diffuse large B-cell lymphoma, NOS]]
 
     - [[T-cell/histiocyte-rich large B-cell lymphoma]]
 
     - [[T-cell/histiocyte-rich large B-cell lymphoma]]
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     - [[Burkitt lymphoma]]
 
     - [[Burkitt lymphoma]]
 
   ''KSHV/HHV8-associated B-cell lymphoid proliferations and lymphomas''
 
   ''KSHV/HHV8-associated B-cell lymphoid proliferations and lymphomas''
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    - [[Introduction]]
   
     - [[Primary effusion lymphoma]]
 
     - [[Primary effusion lymphoma]]
 
     - [[KSHV/HHV8-positive diffuse large B-cell lymphoma]]
 
     - [[KSHV/HHV8-positive diffuse large B-cell lymphoma]]
 
     - [[KSHV/HHV8-positive germinotropic lymphoproliferative disorder]]
 
     - [[KSHV/HHV8-positive germinotropic lymphoproliferative disorder]]
 
   ''Lymphoid proliferations and lymphomas associated with immune deficiency and dysregulation''
 
   ''Lymphoid proliferations and lymphomas associated with immune deficiency and dysregulation''
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    - [[Introduction]]
   
     - [[Hyperplasias arising in immune deficiency/dysregulation]]
 
     - [[Hyperplasias arising in immune deficiency/dysregulation]]
 
     - [[Polymorphic lymphoproliferative disorders arising in immune deficiency / dysregulation ]]
 
     - [[Polymorphic lymphoproliferative disorders arising in immune deficiency / dysregulation ]]
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     - [[Lymphomas arising in immune deficiency / dysregulation ]]
 
     - [[Lymphomas arising in immune deficiency / dysregulation ]]
 
     - [[Inborn error of immunity-associated lymphoid proliferations and lymphomas]]
 
     - [[Inborn error of immunity-associated lymphoid proliferations and lymphomas]]
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===Hodgkin lymphoma===
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    - [[Introduction]]
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'''Hodgkin lymphoma'''
 
     - [[Classic Hodgkin lymphoma ]]
 
     - [[Classic Hodgkin lymphoma ]]
 
     - [[Nodular lymphocyte predominant Hodgkin lymphoma]]
 
     - [[Nodular lymphocyte predominant Hodgkin lymphoma]]
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===Plasma cell neoplasms and other diseases with paraproteins===
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    - [[Introduction]]
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'''Plasma cell neoplasms and other diseases with paraproteins'''
 
   ''Monoclonal gammopathies''
 
   ''Monoclonal gammopathies''
 
     - [[Cold agglutinin disease ]]
 
     - [[Cold agglutinin disease ]]
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     - [[Monoclonal immunoglobulin deposition disease]]
 
     - [[Monoclonal immunoglobulin deposition disease]]
 
   ''Heavy chain diseases''
 
   ''Heavy chain diseases''
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    - [[Introduction]]
   
     - [[Mu heavy chain disease]]
 
     - [[Mu heavy chain disease]]
 
     - [[Gamma heavy chain disease]]
 
     - [[Gamma heavy chain disease]]
 
     - [[Alpha heavy chain disease]]
 
     - [[Alpha heavy chain disease]]
 
   ''Plasma cell neoplasms''
 
   ''Plasma cell neoplasms''
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     - [[Introduction]]
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     - [[HAEM5:Plasmacytoma]]
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    - [[Plasmacytoma]]
   
     - [[Plasma cell myeloma / multiple myeloma]]
 
     - [[Plasma cell myeloma / multiple myeloma]]
 
     - [[Plasma cell neoplasms with associated paraneoplastic syndrome]]
 
     - [[Plasma cell neoplasms with associated paraneoplastic syndrome]]
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==T-cell and NK-cell lymphoid proliferations and lymphomas [[chapter['chapterTitle'|Overview Page Link]]==
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==T-cell and NK-cell lymphoid proliferations and lymphomas ([[T-cell and NK-cell lymphoid proliferations and lymphomas |Overview Page Link]])==
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    - [[Introduction]]
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===Tumour-like lesions with T-cell predominance===
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'''Tumour-like lesions with T-cell predominance'''
 
     - [[Kikuchi-Fujimoto disease]]
 
     - [[Kikuchi-Fujimoto disease]]
 
     - [[Autoimmune lymphoproliferative syndrome]]
 
     - [[Autoimmune lymphoproliferative syndrome]]
 
     - [[Indolent T-lymphoblastic proliferation]]
 
     - [[Indolent T-lymphoblastic proliferation]]
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===Precursor T-cell neoplasms===
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'''Precursor T-cell neoplasms'''
 
   ''T-lymphoblastic leukaemia / lymphoma''
 
   ''T-lymphoblastic leukaemia / lymphoma''
 
     - [[T-lymphoblastic leukaemia / lymphoma, NOS]]
 
     - [[T-lymphoblastic leukaemia / lymphoma, NOS]]
 
     - [[Early T-precursor lymphoblastic leukaemia / lymphoma ]]
 
     - [[Early T-precursor lymphoblastic leukaemia / lymphoma ]]
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===Mature T-cell and NK-cell neoplasms===
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'''Mature T-cell and NK-cell neoplasms'''
 
   ''Mature T-cell and NK-cell leukaemias''
 
   ''Mature T-cell and NK-cell leukaemias''
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    - [[Introduction]]
   
     - [[T-prolymphocytic leukaemia]]
 
     - [[T-prolymphocytic leukaemia]]
 
     - [[T-large granular lymphocytic leukaemia]]
 
     - [[T-large granular lymphocytic leukaemia]]
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    - [[NK-large granular lymphocytic leukaemia]]
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    - [[Adult T-cell leukaemia/lymphoma]]
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    - [[Sezary syndrome]]
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    - [[Aggressive NK-cell leukaemia]]
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  ''Primary cutaneous T-cell lymphoid proliferations and lymphomas''
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    - [[Primary cutaneous CD4-positive small or medium T-cell lymphoproliferative disorder]]
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    - [[Primary cutaneous acral CD8-positive T-cell lymphoproliferative disorder]]
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    - [[Mycosis fungoides]]
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    - [[Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Lymphomatoid papulosis]]
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    - [[Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Primary cutaneous anaplastic large cell lymphoma]]
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    - [[Subcutaneous panniculitis-like T-cell lymphoma]]
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    - [[Primary cutaneous gamma/delta T-cell lymphoma]]
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    - [[Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma]]
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    - [[Primary cutaneous peripheral T-cell lymphoma, NOS]]
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  ''Intestinal T-cell and NK-cell lymphoid proliferations and lymphomas''
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    - [[Indolent T-cell lymphoma of the gastrointestinal tract]]
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    - [[Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract]]
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    - [[Enteropathy-associated T-cell lymphoma]]
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    - [[Monomorphic epitheliotropic intestinal T-cell lymphoma]]
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    - [[Intestinal T-cell lymphoma, NOS]]
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  ''Hepatosplenic T-cell lymphoma''
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    - [[Hepatosplenic T-cell lymphoma]]
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  ''Anaplastic large cell lymphoma''
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    - [[ALK-positive anaplastic large cell lymphoma]]
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    - [[ALK-negative anaplastic large cell lymphoma]]
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    - [[Breast implant-associated anaplastic large cell lymphoma]]
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  ''Nodal T-follicular helper (TFH) cell lymphoma''
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    - [[Nodal TFH cell lymphoma, angioimmunoblastic-type]]
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    - [[Nodal TFH cell lymphoma, follicular-type]]
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    - [[Nodal TFH cell lymphoma, NOS]]
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  ''Other peripheral T-cell lymphomas''
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    - [[Peripheral T-cell lymphoma, NOS]]
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  ''EBV-positive NK-cell and T-cell lymphomas''
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    - [[EBV-positive nodal T- and NK-cell lymphoma]]
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    - [[Extranodal NK/T-cell lymphoma]]
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  ''EBV-positive T-cell and NK-cell lymphoid proliferations and lymphomas of childhood''
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    - [[Severe mosquito bite allergy]]
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    - [[Hydroa vacciniforme lymphoproliferative disorder]]
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    - [[Systemic chronic active EBV disease]]
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    - [[Systemic EBV-positive T-cell lymphoma of childhood]]
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==Stroma-derived neoplasms of lymphoid tissues ([[Stroma-derived neoplasms of lymphoid tissues|Overview Page Link]])==
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'''Mesenchymal dendritic cell neoplasms'''
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  ''Follicular dendritic cell neoplasms''
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    - [[Follicular dendritic cell sarcoma]]
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    - [[EBV-positive inflammatory follicular dendritic cell sarcoma]]
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    - [[Fibroblastic reticular cell tumour]]
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'''Myofibroblastic tumours'''
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  ''Myofibroblastic tumour''
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    - [[Intranodal palisaded myofibroblastoma]]
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'''Spleen-specific vascular-stromal tumours'''
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  ''Splenic vascular-stromal tumours''
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    - [[Littoral cell angioma]]
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    - [[Splenic hamartoma]]
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    - [[Sclerosing angiomatoid nodular transformation (SANT) of spleen]]
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==Genetic tumour syndromes ([[Genetic tumour syndromes|Overview Page Link]])==
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    - [[Fanconi anaemia]]
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    - [[Bloom syndrome]]
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    - [[Ataxia-telangiectasia syndrome]]
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    - [[RASopathies]]
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