Changes

|D

|D

|1

|1

|<ref name=":10">R Bajaj, Xu F, Xiang B, K Wilcox, AJ Diadamo, R Kumar, APietraszkiewicz, S Halene, Li P. Evidence-based genomic diagnosis characterized chromosomal and cryptic imbalances in 30 elderly patients with myelodysplastic syndrome and acute myeloid leukemia. Mol Cytogenet, 4 (2011), p. 3, [https://www.ncbi.nlm.nih.gov/pubmed/21251322 PMID 21251322]</ref><ref name=":14">B Parkin, P Ouillette, M Yildiz, K Saiya-Cork, K Shedden, SN Malek. Integrated genomic profiling, therapy response, and survival in adult acute myelogenous leukemia. Clin Cancer Res Offic J Am Assocr Cancer Res, 21 (2015), pp. 2045-2056, [https://www.ncbi.nlm.nih.gov/pubmed/25652455 PMID 25652455]</ref><ref name=":9" /><ref name=":11">MJ Walter, JE Payton, RE Ries, WD Shannon, H Deshmukh, ZhaoY, J Baty, S Heath, P Westervelt, MA Watson, MH Tomasson, RNagarajan, BP O'Gara, CD Bloomfield, K Mrozek, RR Selzer, TARichmond, J Kitzman, J Geoghegan, PS Eis, R Maupin, RS Fulton, M McLellan, RK Wilson, ER Mardis, DC Link, TA Graubert, JFDiPersio, TJ Ley. Acquired copy number alterations in adult acute myeloid leukemia genomes. Proc Natl Acad Sci USA, 106 (2009), pp. 12950-12955, [https://www.ncbi.nlm.nih.gov/pubmed/19651600 PMID 19651600]</ref><ref name=":7" /><ref name=":8" /><ref name=":15">FG Rucker, RF Schlenk, L Bullinger, S Kayser, V Teleanu, H Kett, MHabdank, CM Kugler, K Holzmann, VI Gaidzik, P Paschka, GHeld, M von Lilienfeld-Toal, M Lubbert, S Frohling, T Zenz, JKrauter, B Schlegelberger, A Ganser, P Lichter, K Dohner, HDohner. TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome. Blood, 119 (2012), pp. 2114-2121, [https://www.ncbi.nlm.nih.gov/pubmed/22186996 PMID 22186996]</ref><ref>A Jerez, LP Gondek, AM Jankowska, H Makishima, B Przychodzen, Tiu RV, CL O'Keefe, AM Mohamedali, D Batista, MA Sekeres, MAMcDevitt, GJ Mufti, JP Maciejewski. Topography, clinical, and genomic correlates of 5q myeloid malignancies revisited. J Clin Oncol Offic J Am Soc Clin Oncol, 30 (2012), pp. 1343-1349, [https://www.ncbi.nlm.nih.gov/pubmed/22370328 PMID 22370328]</ref><ref>M Mehrotra, R Luthra, F Ravandi, RL Sargent, BA Barkoh, RAbraham, BM Mishra, LJ Medeiros, KP Patel. Identification of clinically important chromosomal aberrations in acute myeloid leukemia by array-based comparative genomic hybridization. Leukemia Lymph, 55 (2014), pp. 2538-2548, [https://www.ncbi.nlm.nih.gov/pubmed/24446873 PMID 24446873]</ref><ref>Kim MH, J Stewart, C Devlin, Kim YT, E Boyd, M Connor. The application of comparative genomic hybridization as an additional tool in the chromosome analysis of acute myeloid leukemia and myelodysplastic syndromes. Cancer Genet Cytogen, 126 (2001), pp. 26-33, [https://www.ncbi.nlm.nih.gov/pubmed/11343775 PMID 11343775]</ref><ref>Rumi E, Harutyunyan A, Elena C, Pietra D, Klampfl T, Bagien-ski K, Berg T, Casetti I, Pascutto C, Passamonti F, Kralovics R, Cazzola M. Identification of genomic aberrations associated with disease transformation by means of high resolution SNP array analysis in patients with myeloproliferative neoplasm. Am J Hematol 2011;86:974–9, [https://www.ncbi.nlm.nih.gov/pubmed/21953568 PMID 21953568]</ref><ref name=":16">LP Gondek, Tiu R, CL O'Keefe, MA Sekeres, KS Theil, JPMaciejewski. Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML. Blood, 111 (2008), pp. 1534-1542, [https://www.ncbi.nlm.nih.gov/pubmed/17954704 PMID 17954704]</ref>

|<ref name=":7" /><ref name=":8" /><ref name=":9" /><ref name=":10">R Bajaj, Xu F, Xiang B, K Wilcox, AJ Diadamo, R Kumar, APietraszkiewicz, S Halene, Li P. Evidence-based genomic diagnosis characterized chromosomal and cryptic imbalances in 30 elderly patients with myelodysplastic syndrome and acute myeloid leukemia. Mol Cytogenet, 4 (2011), p. 3, [https://www.ncbi.nlm.nih.gov/pubmed/21251322 PMID 21251322]</ref><ref name=":14">B Parkin, P Ouillette, M Yildiz, K Saiya-Cork, K Shedden, SN Malek. Integrated genomic profiling, therapy response, and survival in adult acute myelogenous leukemia. Clin Cancer Res Offic J Am Assocr Cancer Res, 21 (2015), pp. 2045-2056, [https://www.ncbi.nlm.nih.gov/pubmed/25652455 PMID 25652455]</ref><ref name=":11">MJ Walter, JE Payton, RE Ries, WD Shannon, H Deshmukh, ZhaoY, J Baty, S Heath, P Westervelt, MA Watson, MH Tomasson, RNagarajan, BP O'Gara, CD Bloomfield, K Mrozek, RR Selzer, TARichmond, J Kitzman, J Geoghegan, PS Eis, R Maupin, RS Fulton, M McLellan, RK Wilson, ER Mardis, DC Link, TA Graubert, JFDiPersio, TJ Ley. Acquired copy number alterations in adult acute myeloid leukemia genomes. Proc Natl Acad Sci USA, 106 (2009), pp. 12950-12955, [https://www.ncbi.nlm.nih.gov/pubmed/19651600 PMID 19651600]</ref><ref name=":15">FG Rucker, RF Schlenk, L Bullinger, S Kayser, V Teleanu, H Kett, MHabdank, CM Kugler, K Holzmann, VI Gaidzik, P Paschka, GHeld, M von Lilienfeld-Toal, M Lubbert, S Frohling, T Zenz, JKrauter, B Schlegelberger, A Ganser, P Lichter, K Dohner, HDohner. TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome. Blood, 119 (2012), pp. 2114-2121, [https://www.ncbi.nlm.nih.gov/pubmed/22186996 PMID 22186996]</ref><ref>A Jerez, LP Gondek, AM Jankowska, H Makishima, B Przychodzen, Tiu RV, CL O'Keefe, AM Mohamedali, D Batista, MA Sekeres, MAMcDevitt, GJ Mufti, JP Maciejewski. Topography, clinical, and genomic correlates of 5q myeloid malignancies revisited. J Clin Oncol Offic J Am Soc Clin Oncol, 30 (2012), pp. 1343-1349, [https://www.ncbi.nlm.nih.gov/pubmed/22370328 PMID 22370328]</ref><ref>M Mehrotra, R Luthra, F Ravandi, RL Sargent, BA Barkoh, RAbraham, BM Mishra, LJ Medeiros, KP Patel. Identification of clinically important chromosomal aberrations in acute myeloid leukemia by array-based comparative genomic hybridization. Leukemia Lymph, 55 (2014), pp. 2538-2548, [https://www.ncbi.nlm.nih.gov/pubmed/24446873 PMID 24446873]</ref><ref>Kim MH, J Stewart, C Devlin, Kim YT, E Boyd, M Connor. The application of comparative genomic hybridization as an additional tool in the chromosome analysis of acute myeloid leukemia and myelodysplastic syndromes. Cancer Genet Cytogen, 126 (2001), pp. 26-33, [https://www.ncbi.nlm.nih.gov/pubmed/11343775 PMID 11343775]</ref><ref>Rumi E, Harutyunyan A, Elena C, Pietra D, Klampfl T, Bagien-ski K, Berg T, Casetti I, Pascutto C, Passamonti F, Kralovics R, Cazzola M. Identification of genomic aberrations associated with disease transformation by means of high resolution SNP array analysis in patients with myeloproliferative neoplasm. Am J Hematol 2011;86:974–9, [https://www.ncbi.nlm.nih.gov/pubmed/21953568 PMID 21953568]</ref><ref name=":16">LP Gondek, Tiu R, CL O'Keefe, MA Sekeres, KS Theil, JPMaciejewski. Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML. Blood, 111 (2008), pp. 1534-1542, [https://www.ncbi.nlm.nih.gov/pubmed/17954704 PMID 17954704]</ref>

|-

|-

|6

|6

|D

|D

|1

|1

|<ref name=":18">Huh J, Jung CW, Kim HJ, Kim YK, Moon JH, Sohn SK, Kim HJ, Min WS, Kim DH. Different characteristics identified by single nucleotide polymorphism array analysis in leukemia suggest the need for different application strategies depending on disease category. Genes Chromos cancer, 52 (2013), pp. 44-55, [https://www.ncbi.nlm.nih.gov/pubmed/23023762 PMID 23023762]</ref><ref name=":7" /><ref name=":8" /><ref>ME McNerney, CD Brown, X Wang, ET Bartom, S Karmakar, CBandlamudi, Yu S, Ko J, BP Sandall, T Stricker, J Anastasi, RLGrossman, JM Cunningham, MM Le Beau, KP White. CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia. Blood, 121 (2013), pp. 975-983, [https://www.ncbi.nlm.nih.gov/pubmed/23212519 PMID 23212519]</ref>

|<ref name=":7" /><ref name=":8" /><ref name=":18">Huh J, Jung CW, Kim HJ, Kim YK, Moon JH, Sohn SK, Kim HJ, Min WS, Kim DH. Different characteristics identified by single nucleotide polymorphism array analysis in leukemia suggest the need for different application strategies depending on disease category. Genes Chromos cancer, 52 (2013), pp. 44-55, [https://www.ncbi.nlm.nih.gov/pubmed/23023762 PMID 23023762]</ref><ref>ME McNerney, CD Brown, X Wang, ET Bartom, S Karmakar, CBandlamudi, Yu S, Ko J, BP Sandall, T Stricker, J Anastasi, RLGrossman, JM Cunningham, MM Le Beau, KP White. CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia. Blood, 121 (2013), pp. 975-983, [https://www.ncbi.nlm.nih.gov/pubmed/23212519 PMID 23212519]</ref>

|-

|-

|8

|8

|D

|D

|3

|3

|<ref name=":8" /><ref name=":3" /><ref name=":5" />

|<ref name=":3" /><ref name=":5" /><ref name=":8" />

|-

|-

|11*

|11*

|D

|D

|3

|3

|<ref name=":0" /><ref name=":2" /><ref name=":6" /><ref name=":4" />

|<ref name=":0" /><ref name=":2" /><ref name=":4" /><ref name=":6" />

|-

|-

|11

|11

|D

|D

|3

|3

|<ref name=":0" /><ref name=":6" /><ref name=":8" /><ref name=":3" /><ref name=":4" />

|<ref name=":0" /><ref name=":3" /><ref name=":4" /><ref name=":6" /><ref name=":8" />

|-

|-

|12

|12

|D

|D

|3

|3

|<ref name=":10" /><ref name=":2" /><ref name=":14" /><ref name=":11" /><ref name=":7" /><ref name=":8" /><ref name=":15" /><ref name=":5" /><ref name=":16" /><ref name=":19" /><ref>Paulsson K, Heidenblad M, Strombeck B, Staaf J, Jonsson G, Borg A, Fioretos T, Johansson B. High-resolution genome-wide array-based comparative genome hybridization reveals cryptic chromosome changes in AML and MDS cases with trisomy 8 as the sole cytogenetic aberration. Leukemia 2006;20:840–6. [https://www.ncbi.nlm.nih.gov/pubmed/16498392 PMID 16498392]</ref><ref>Feurstein S, Rucker FG, Bullinger L, Hofmann W, Manuk-jan G, Gohring G, Lehmann U, Heuser M, Ganser A, Dohner K, Schlegelberger B, Steinemann D. Haploinsufficiency of ETV6 and CDKN1B in patients with acute myeloid leukemia and complex karyotype. BMC Genom 2014;15:784. [https://www.ncbi.nlm.nih.gov/pubmed/25213837 PMID 25213837]</ref><ref>Zhang R, Kim YM, Wang X, Li Y, Lu X, Sternenberger AR, Li S, Lee JY. Genomic copy number variations in the myelodysplastic syndrome and acute myeloid leukemia patients with del(5q) and/or -7/del(7q). Int J Med Sci 2015;12:719–26, [https://www.ncbi.nlm.nih.gov/pubmed/26392809 PMID 26392809]</ref><ref>Wall M, Rayeroux KC, MacKinnon RN, Zordan A, Campbell LJ. ETV6 deletion is a common additional abnormality in patients with myelodysplastic syndromes or acute myeloid leukemia and monosomy 7. Haematologica 2012;97:1933–6., [https://www.ncbi.nlm.nih.gov/pubmed/22875624 PMID 22875624]</ref>

|<ref name=":2" /><ref name=":5" /><ref name=":7" /><ref name=":8" /><ref name=":10" /><ref name=":14" /><ref name=":11" /><ref name=":15" /><ref name=":16" /><ref name=":19" /><ref>Paulsson K, Heidenblad M, Strombeck B, Staaf J, Jonsson G, Borg A, Fioretos T, Johansson B. High-resolution genome-wide array-based comparative genome hybridization reveals cryptic chromosome changes in AML and MDS cases with trisomy 8 as the sole cytogenetic aberration. Leukemia 2006;20:840–6. [https://www.ncbi.nlm.nih.gov/pubmed/16498392 PMID 16498392]</ref><ref>Feurstein S, Rucker FG, Bullinger L, Hofmann W, Manuk-jan G, Gohring G, Lehmann U, Heuser M, Ganser A, Dohner K, Schlegelberger B, Steinemann D. Haploinsufficiency of ETV6 and CDKN1B in patients with acute myeloid leukemia and complex karyotype. BMC Genom 2014;15:784. [https://www.ncbi.nlm.nih.gov/pubmed/25213837 PMID 25213837]</ref><ref>Zhang R, Kim YM, Wang X, Li Y, Lu X, Sternenberger AR, Li S, Lee JY. Genomic copy number variations in the myelodysplastic syndrome and acute myeloid leukemia patients with del(5q) and/or -7/del(7q). Int J Med Sci 2015;12:719–26, [https://www.ncbi.nlm.nih.gov/pubmed/26392809 PMID 26392809]</ref><ref>Wall M, Rayeroux KC, MacKinnon RN, Zordan A, Campbell LJ. ETV6 deletion is a common additional abnormality in patients with myelodysplastic syndromes or acute myeloid leukemia and monosomy 7. Haematologica 2012;97:1933–6., [https://www.ncbi.nlm.nih.gov/pubmed/22875624 PMID 22875624]</ref>

|-

|-

|13*

|13*

|D, P

|D, P

|2

|2

|<ref name=":0" /><ref name=":18" /><ref name=":1" /><ref name=":2" /><ref>Tiu RV, LP Gondek, CL O'Keefe, Huh J, MA Sekeres, P Elson, MAMcDevitt, Wang XF, MJ Levis, JE Karp, AS Advani, JP Maciejewski. New lesions detected by single nucleotide polymorphism array-based chromosomal analysis have important clinical impact in acute myeloid leukemia. J Clin Oncol Off J Am Soc Clin Oncol, 27 (2009), pp. 5219-5226, [https://www.ncbi.nlm.nih.gov/pubmed/19770377 PMID 19770377]</ref><ref name=":6" /><ref name=":8" /><ref name=":3" /><ref name=":12" /><ref name=":13" /><ref name=":4" /><ref name=":5" /><ref name=":17" />

|<ref name=":0" /><ref name=":1" /><ref name=":2" /><ref name=":3" /><ref name=":12" /><ref name=":13" /><ref name=":4" /><ref name=":5" /><ref name=":6" /><ref name=":8" /><ref name=":17" /><ref name=":18" /><ref>Tiu RV, LP Gondek, CL O'Keefe, Huh J, MA Sekeres, P Elson, MAMcDevitt, Wang XF, MJ Levis, JE Karp, AS Advani, JP Maciejewski. New lesions detected by single nucleotide polymorphism array-based chromosomal analysis have important clinical impact in acute myeloid leukemia. J Clin Oncol Off J Am Soc Clin Oncol, 27 (2009), pp. 5219-5226, [https://www.ncbi.nlm.nih.gov/pubmed/19770377 PMID 19770377]</ref>

|-

|-

|16

|16