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− | Acute Myeloid Leukemia (AML) and Related Precursor Neoplasms
| + | [[File:Dic(9 12).tif|300px]] |
− | *[[Acute Myeloid Leukemia (AML) with Recurrent Genetic Abnormalities|Recurrent Genetic Abnormalities]]
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− | **[[Acute Myeloid Leukemia (AML) with t(8;21)(q22;q22.1); RUNX1-RUNX1T1|t(8;21)(q22;q22.1); RUNX1-RUNX1T1]]
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− | **Acute Myeloid Leukemia (AML) with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11
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− | *Acute Myeloid Leukemia (AML) with Myelodysplasia-Related Changes
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− | **sub division
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− | ***sub-sub-sub division
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| + | ==Myeloproliferative Neoplasms (MPN)== |
| + | *[[HAEM5:Chronic myeloid leukaemia]] |
| + | *[[HAEM5:Chronic neutrophilic leukaemia]] |
| + | *[[HAEM5:Polycythaemia vera]] |
| + | *[[HAEM5:Primary myelofibrosis]] |
| + | *[[HAEM5:Chronic eosinophilic leukaemia]] |
| + | *[[HAEM5:Myeloproliferative neoplasm, NOS]] |
| + | *[[Some new stuff]] |
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− | *[[Acute Myeloid Leukemia (AML) with Recurrent Genetic Abnormalities]]
| + | '''Primary Author(s)*''' |
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− | - [[Acute Myeloid Leukemia (AML) with t(8;21)(q22;q22.1); RUNX1-RUNX1T1]]
| + | Put your text here |
− | - [[Acute Myeloid Leukemia (AML) with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11]]
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− | - [[Acute Promyelocytic Leukemia (APL) with PML-RARA]]
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− | - [[Acute Myeloid Leukemia (AML) with t(9;11)(p21.3;q23.3); KMT2A-MLLT3]]
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− | - [[Acute Myeloid Leukemia (AML) with t(6;9)(p23;q34.1); DEK-NUP214]]
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− | - [[Acute Myeloid Leukemia (AML) with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2);GATA2, MECOM]]
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− | - [[Acute Myeloid Leukemia (AML) Megakaryoblastic with t(1;22)(p13.3;q13.1);RBM15-MKL1]]
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− | - [[Acute Myeloid Leukemia (AML) with BCR-ABL1]]
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− | - [[Acute Myeloid Leukemia (AML) with Mutated NPM1]]
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− | - [[Acute Myeloid Leukemia (AML) with Biallelic Mutations of CEBPA]]
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− | - [[Acute Myeloid Leukemia (AML) with Mutated RUNX1]]
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− | *[[Acute Myeloid Leukemia (AML) with Myelodysplasia-Related Changes]]
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− | *[[Therapy-Related Myeloid Neoplasms]]
| + | '''Cancer Category/Type''' |
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− | *[[Acute Myeloid Leukemia (AML), Not Otherwise Specified]]
| + | Put your text here |
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− | - [[Acute Myeloid Leukemia (AML) with Minimal Differentiation]]
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− | - [[Acute Myeloid Leukemia (AML) without Maturation]]
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− | - [[Acute Myeloid Leukemia (AML) with Maturation]]
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− | - [[Acute Myelomonocytic Leukemia]]
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− | - [[Acute Monoblastic and Monocytic Leukemia]]
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− | - [[Pure Erythroid Leukemia]]
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− | - [[Acute Megakaryoblastic Leukemia (AMKL)]]
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− | - [[Acute Basophilic Leukemia]]
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− | - [[Acute Panmyelosis with Myelofibrosis]]
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− | *[[Myeloid Sarcoma]]
| + | '''Cancer Sub-Classification/Subtype''' |
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− | *[[Myeloid Proliferations Associated with Down Syndrome]]
| + | Put your text here |
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− | - [[Transient Abnormal Myelopoiesis (TAM) Associated with Down Syndrome]]
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− | - [[Myeloid Leukemia Associated with Down Syndrome]]
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− | *[[Blastic Plasmacytoid Dendritic Cell Neoplasm]]
| + | '''Definition/Description of Disease''' |
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− | *[[Acute Leukemias of Ambiguous Lineage]]
| + | Put your text here |
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− | - [[Acute Undifferentiated Leukemia]]
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− | - [[Mixed Phenotype Acute Leukemia (MPAL) with t(9;22)(q34.1;q11.2); BCR-ABL1]]
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− | - [[Mixed Phenotype Acute Leukemia (MPAL) with t(v;11q23.3); KMT2A Rearranged]]
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− | - [[Mixed Phenotype Acute Leukemia (MPAL), B/Myeloid, Not Otherwise Specified]]
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− | - [[Mixed Phenotype Acute Leukemia (MPAL), T/Myeloid, Not Otherwise Specified]]
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− | - [[Mixed-Phenotype Acute Leukemia, Not Otherwise Specified (NOS), Rare Types]]
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− | - [[Acute Leukemias of Ambiguous Lineage, Not Otherwise Specified (NOS)]]
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− | *[[Myeloid Neoplasms with Germline Predisposition]]
| + | '''Synonyms/Terminology''' |
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− | - [[Acute Myeloid Leukaemia with Germline CEBPA Mutation]]
| + | Put your text here |
− | - [[Myeloid Neoplasms with Germline DDX41 Mutation]]
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− | - [[Myeloid Neoplasms with Germline RUNX1 Mutation]]
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− | - [[Myeloid Neoplasms with Germline ANKRD26 Mutation]]
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− | - [[Myeloid Neoplasms with Germline ETV6 Mutation]]
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− | - [[Myeloid Neoplasms with Germline GATA2 Mutation]]
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| + | '''Epidemiology/Prevalence''' |
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| + | Put your text here |
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| + | '''Clinical Features''' |
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− | *[[Myelodysplastic Syndrome (MDS) with Single Lineage Dysplasia]]
| + | Put your text here and fill in the table |
− | *[[Myelodysplastic Syndrome with Ring Sideroblasts (MDS-RS)]]
| + | <br /> |
− | *[[Myelodysplastic Syndrome with Ring Sideroblasts and Multilineage Dysplasia]]
| + | {| class="wikitable" |
− | *[[Myelodysplastic Syndrome (MDS) with Multilineage Dysplasia]]
| + | |'''Signs and Symptoms''' |
− | *[[Myelodysplastic Syndrome (MDS) with Excess Blasts]]
| + | |EXAMPLE Asymptomatic (incidental finding on complete blood counts) |
− | *[[Myelodysplastic Syndrome (MDS) with Isolated del(5q)]]
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− | *[[Myelodysplastic Syndrome (MDS), Unclassifiable]]
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− | *[[Refractory Cytopenia of Childhood]]
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| + | EXAMPLE B-symptoms (weight loss, fever, night sweats) |
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| + | EXAMPLE Fatigue |
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| + | EXAMPLE Lymphadenopathy (uncommon) |
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| + | |'''Laboratory Findings''' |
| + | |EXAMPLE Cytopenias |
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− | *[[Chronic Myeloid Leukemia (CML), BCR-ABL1 Positive]]
| + | EXAMPLE Lymphocytosis (low level) |
− | *[[Chronic Neutrophilic Leukemia (CNL)]]
| + | |} |
− | *[[Polycythemia Vera (PV)]]
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− | *[[Primary Myelofibrosis (PMF)]]
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− | *[[Essential Thrombocythemia (ET)]]
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− | *[[Chronic Eosinophilic Leukemia, Not Otherwise Specified]]
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− | *[[Myeloproliferative Neoplasm (MPN), Unclassifiable]]
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− | #[[Chronic Myelomonocytic Leukemia (CMML)]]
| + | '''Sites of Involvement''' |
− | #[[Atypical Chronic Myeloid Leukemia (aCML), BCR-ABL1 Negative]]
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− | #[[Juvenile Myelomonocytic Leukemia (JMML)]]
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− | #[[Myelodysplastic/Myeloproliferative Neoplasms with Ring Sideroblasts and Thrombocytosis (MDS/MPN-RS-T)]]
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− | #[[Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN), Unclassifiable]]
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− | <comments /> | + | Put your text here |
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| + | '''Morphologic Features''' |
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| + | '''Immunophenotype''' |
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| + | Put your text here and fill in the table |
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| + | {| class="wikitable" |
| + | |'''Positive (universal)''' |
| + | |EXAMPLE CD1 |
| + | |- |
| + | |'''Positive (subset)''' |
| + | |EXAMPLE CD2 |
| + | |- |
| + | |'''Negative (universal)''' |
| + | |EXAMPLE CD3 |
| + | |- |
| + | |'''Negative (subset)''' |
| + | |EXAMPLE CD4 |
| + | |} |
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| + | '''Chromosomal Rearrangements (Gene Fusions)''' |
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| + | Put your text here and fill in the table |
| + | <br /> |
| + | {| class="wikitable" |
| + | |'''Chromosomal Rearrangement''' |
| + | |'''Genes in Fusion''' |
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| + | '''(5’ or 3’ Segments)''' |
| + | |'''Pathogenic Derivative''' |
| + | |'''Prevalence''' |
| + | |'''Diagnostic Significance (Yes, No or Unknown)''' |
| + | |'''Prognostic Significance (Yes, No or Unknown)''' |
| + | |'''Therapeutic Significance (Yes, No or Unknown)''' |
| + | |'''Notes''' |
| + | |- |
| + | |EXAMPLE t(9;22)(q34;q11.2) |
| + | |EXAMPLE 3'ABL1 / 5'BCR |
| + | |EXAMPLE der(22) |
| + | |EXAMPLE 20% (COSMIC) |
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| + | EXAMPLE 30% (add reference) |
| + | |Yes |
| + | |No |
| + | |Yes |
| + | |EXAMPLE |
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| + | The t(9;22) is diagnostic of CML in the appropriate morphology and clinical context (add reference). This fusion is responsive to targeted therapy such as Imatinib (Gleevec) (add reference). |
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| + | '''Individual Region Genomic Gain/Loss/LOH''' |
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| + | Put your text here and fill in the table |
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| + | {| class="wikitable" |
| + | |'''Chr #''' |
| + | |'''Gain/Loss/Amp/LOH''' |
| + | |'''Minimal Region Genomic Coordinates [Genome Build]''' |
| + | |'''Minimal Region Cytoband''' |
| + | |'''Diagnostic Significance (Yes, No or Unknown)''' |
| + | |'''Prognostic Significance''' |
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| + | '''(Yes, No or Unknown)''' |
| + | |'''Therapeutic Significance''' |
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| + | '''(Yes, No or Unknown)''' |
| + | |'''Notes''' |
| + | |- |
| + | |EXAMPLE |
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| + | 7 |
| + | |EXAMPLE Loss |
| + | |EXAMPLE |
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| + | chr7:1- 159,335,973 [hg38] |
| + | |EXAMPLE |
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| + | chr7 |
| + | |Yes |
| + | |Yes |
| + | |No |
| + | |EXAMPLE |
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| + | Presence of monosomy 7 (or 7q deletion) is sufficient for a diagnosis of AML with MDS-related changes when there is ≥20% blasts and no prior therapy (add reference). Monosomy 7/7q deletion is associated with a poor prognosis in AML (add reference). |
| + | |- |
| + | |EXAMPLE |
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| + | 8 |
| + | |EXAMPLE Gain |
| + | |EXAMPLE |
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| + | chr8:1-145,138,636 [hg38] |
| + | |EXAMPLE |
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| + | chr8 |
| + | |No |
| + | |No |
| + | |No |
| + | |EXAMPLE |
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| + | Common recurrent secondary finding for t(8;21) (add reference). |
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| + | '''Characteristic Chromosomal Patterns''' |
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| + | Put your text here |
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| + | {| class="wikitable" |
| + | |'''Chromosomal Pattern''' |
| + | |'''Diagnostic Significance (Yes, No or Unknown)''' |
| + | |'''Prognostic Significance''' |
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| + | '''(Yes, No or Unknown)''' |
| + | |'''Therapeutic Significance''' |
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| + | '''(Yes, No or Unknown)''' |
| + | |'''Notes''' |
| + | |- |
| + | |EXAMPLE |
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| + | Co-deletion of 1p and 18q |
| + | |Yes |
| + | |No |
| + | |No |
| + | |EXAMPLE: |
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| + | See chromosomal rearrangements table as this pattern is due to an unbalanced derivative translocation associated with oligodendroglioma (add reference). |
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| + | '''Gene Mutations (SNV/INDEL)''' |
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| + | Put your text here and fill in the table |
| + | {| class="wikitable" |
| + | |'''Gene; Genetic Alteration''' |
| + | |'''Presumed Mechanism (Tumor Suppressor Gene (TSG)/Oncogene/Other)''' |
| + | |'''Prevalence (COSMIC/ TCGA/Other)''' |
| + | |'''Concomitant Mutations''' |
| + | |'''Mutually Exclusive Mutations''' |
| + | |'''Diagnostic Significance (Yes, No or Unknown)''' |
| + | |'''Prognostic Significance''' |
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| + | '''(Yes, No or Unknown)''' |
| + | |'''Therapeutic Significance''' |
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| + | '''(Yes, No or Unknown)''' |
| + | |'''Notes''' |
| + | |- |
| + | |EXAMPLE: TP53; Variable LOF mutations |
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| + | EXAMPLE: |
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| + | EGFR; Exon 20 mutations |
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| + | EXAMPLE: BRAF; Activating mutations |
| + | |EXAMPLE: TSG |
| + | |EXAMPLE: 20% (COSMIC) |
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| + | EXAMPLE: 30% (add Reference) |
| + | |EXAMPLE: IDH1 R123H |
| + | |EXAMPLE: EGFR amplification |
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| + | |EXAMPLE: Excludes hairy cell leukemia (HCL) (add reference). |
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| + | |} |
| + | Note: A more extensive list of mutations can be found in cBioportal (<nowiki>https://www.cbioportal.org/</nowiki>), COSMIC (<nowiki>https://cancer.sanger.ac.uk/cosmic</nowiki>), ICGC (<nowiki>https://dcc.icgc.org/</nowiki>) and/or other databases. When applicable, gene-specific pages within the CCGA site directly link to pertinent external content. |
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| + | '''Epigenomic Alterations''' |
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| + | '''Genes and Main Pathways Involved''' |
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| + | Put your text here and fill in the table |
| + | {| class="wikitable" |
| + | |'''Gene; Genetic Alteration''' |
| + | |'''Pathway''' |
| + | |'''Pathophysiologic Outcome''' |
| + | |- |
| + | |EXAMPLE: BRAF and MAP2K1; Activating mutations |
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| + | EXAMPLE: CDKN2A; Inactivating mutations |
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| + | EXAMPLE: KMT2C and ARID1A; Inactivating mutations |
| + | |EXAMPLE: MAPK signaling |
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| + | EXAMPLE: Cell cycle regulation |
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| + | EXAMPLE: Histone modification, chromatin remodeling |
| + | |EXAMPLE: Increased cell growth and proliferation |
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| + | EXAMPLE: Unregulated cell division |
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| + | EXAMPLE: Abnormal gene expression program |
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| + | |} |
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| + | '''Genetic Diagnostic Testing Methods''' |
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| + | '''Familial Forms''' |
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| + | '''Additional Information''' |
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| + | '''Links''' |
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| + | Put your text placeholder here (use "Link" icon at top of page) |
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| + | '''References''' |
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| + | (use "Cite" icon at top of page) |
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| + | BOOK EXAMPLE: Arber DA, et al., (2017). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, Revised 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, and Siebert R, Editors. IARC Press: Lyon, France, p130-149. |
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| + | '''Notes''' |
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| + | <nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome. |