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|Activation of MYC pathway is often seen with loss of  9p (CDKN2A/B), and 14q (MAX gene)  and is reported to have a worse prognosis
 
|Activation of MYC pathway is often seen with loss of  9p (CDKN2A/B), and 14q (MAX gene)  and is reported to have a worse prognosis
 
|PMID:27090007; PMID:26061753; PMID:25263767 PMID:26061754; PMID:24335697; PMID:25664944;PMID:26061753; PMID:26941959; PMID:26824661 PMID:26061751   
 
|PMID:27090007; PMID:26061753; PMID:25263767 PMID:26061754; PMID:24335697; PMID:25664944;PMID:26061753; PMID:26941959; PMID:26824661 PMID:26061751   
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|Glioblastoma , grade IV, IDH mutant
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|'''Gain:''' 1/1q, 6p<br>
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'''Loss:''' 3p, 10, 13, 14, 15, 22 (3, 4q, 19q, 16p, 21q, 5p  seen in age <40)<br>
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'''Amplification:''' CDK6, cyclin E2, CDK4, MET<br>
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'''Chromothripsis'''
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|'''Gain or Amplification:''' CDK4, CDK6, cyclin E2<br>
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'''Loss:''' PTEN
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|About 10% of glioblastomas; correspond closely to secondary glioblastoma with history of prior glioma.  These cases often involve loss of 10q , gain of CDK4, CDK6, cyclin E2, and increase in copy number alterations.
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|PMID:26061754; PMID:25754088; PMID:28535583 PMID:25931051; PMID:26091668; PMID:25461780; PMID:27157931; PMID:25727226; PMID:26323991 PMID:26061751; PMID:29687258
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|Glioblastoma , grade IV, IDH wildtype
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|'''Loss:''' 4, 9p, 10, 13, 14, 15, 22 , (3, 4q, 19q, 16p, 21q, 5p loss in age <40)<br>
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'''Gain:''' 7, 19, 20  (1q, 12p, 11q, 9q, 4, 10p gain in age <40) <br>
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'''Amplification:''' EGFR, MDM4, CDK4, MET
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|'''Loss:''' homozygous CDKN2A/B, PTEN, RB1<br>
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'''Mutation:''' TERT, EGFR, PTEN, NF1, RB1, PIK3CA or PIK3R1, TP53<br>
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'''Amplification:'''  EGFR, MDM4, MDM2, CDK4, PDGFRA, MET 
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|Overall poor prognosis.    Gain of 19q, amplification of EGFR, and homozygous loss of CDKN2A are seen primarily in patients over age 40. Co-gain of 19 and 20 may be associated with longer survival.
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|PMID:26061754; PMID:25754088; PMID:28535583 PMID:25931051; PMID:26091668; PMID:25461780; PMID:27157931; PMID:25727226; PMID:26061751     
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|-
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|'''MENINGIOMA'''
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|-
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|Grade 1
 
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