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|PMID:25752754; PMID:25727226; PMID:26328271; PMID:22837387;  PMID:25754088; PMID:25461780; PMCID:1891902; PMID:23417712; PMCID:5323185;  PMID:29687258; PMID:20479398; PMID:24959384
 
|PMID:25752754; PMID:25727226; PMID:26328271; PMID:22837387;  PMID:25754088; PMID:25461780; PMCID:1891902; PMID:23417712; PMCID:5323185;  PMID:29687258; PMID:20479398; PMID:24959384
 
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|Diffuse midline glioma, H3 K27M mutant
 
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|'''Gain:''' 1q, 2, 7, 8 '''Loss:''' 10q '''Chromothripsis:''' 2p
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|'''Three molecular subgroups:''' '''MYCN subgroup:''' no mutations but chromothripsis leading to amp of MYCN and ID2; '''Silent subgroup:''' no recurrent copy # changes, few mutations; '''H3-K27M subgroup:''' MYC, PDGFRA gains/amp; RB1, TP53 deletions '''Mutation:''' ACVR1, H3F3A, HIST1H3B, TP53 '''Loss:''' CDKN2A, PTEN, RB1, TP53 '''Amplification:''' MYC, MYCN, ID2, PDGFRA
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|Overall poor prognosis regardless of subgroup
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|PMCID:3280796; PMID:24705254; PMID:24705252 PMID:27048880; PMID:26175967; PMID:24705251; PMID:28966033