SET-NUP214
Revision as of 10:31, 31 August 2016 by ChrisWenzinger2 (talk | contribs)
Contributors
Daynna J. Wolff, PhD
Description
NUP214-SET is a fusion of the genes NUP214 (Nucleoporin 214kDa) and SET (SET Nuclear Proto-Oncogene), located at 9q34.13 and 9q34.11, respectively. The fusion has been described as resulting from a recurrent cryptic deletion, del(9)(q34.11q34.13) and a chromosomal translocation, t(9;9)(q34;q34) [5].
Tumor Types
T-cell Acute Lymphoblastic Leukemia
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Prevalence
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Genes Involved / Domains Affected
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Diagnostic Testing
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Clinical Significance
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Therapeutics
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Links
References
- ↑ Reference: Ann Clin Lab Sci. 2011 Summer;41(3):267-72. T-cell acute lymphoblastic leukemia associated with complex karyotype and SET-NUP214 rearrangement: a case study and review of the literature. Lee SG1, Park TS, Cho SY, Lim G, Park GJ, Oh SH, Cho EH, Chong SY, Huh JY. PMID: 22075511 http://www.ncbi.nlm.nih.gov/pubmed/22075511
- ↑ Ann Hematol. 2012 Feb;91(2):193-201. doi: 10.1007/s00277-011-1289-x. Epub 2011 Jul 1.
- ↑ Phenotypic and genetic characterization of adult T-cell acute lymphoblastic leukemia with del(9)(q34);SET-NUP214 rearrangement. Chae H1, Lim J, Kim M, Park J, Kim Y, Han K, Lee S, Min WS. PMID: http://www.ncbi.nlm.nih.gov/pubmed/21720744 Oncol Lett. 2014 Sep; 8(3): 959–962. Published online 2014 Jun 18. doi: 10.3892/ol.2014.2263 PMCID: PMC4114590
- ↑ NUP214 fusion genes in acute leukemia (Review) MIN-HANG ZHOU and QING-MING YANG PMID: http://www.ncbi.nlm.nih.gov/pubmed/25120641
- ↑ SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines. Quentmeier H, Schneider B, Röhrs S, et al. J Hematol Oncol. 2009;2:3. PMID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636835/#B1