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| == Description == | | == Description == |
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− | NUP214-SET is a fusion of the genes ''NUP214'' (Nucleoporin 214kDa) and ''SET'' (SET Nuclear Proto-Oncogene), located at 9q34.13 and 9q34.11, respectively. The fusion has been described as resulting from a recurrent cryptic deletion, del(9)(q34.11q34.13) and a chromosomal translocation, t(9;9)(q34;q34) [5,6]. | + | NUP214-SET is a fusion of the genes ''NUP214'' (Nucleoporin 214kDa) and ''SET'' (SET Nuclear Proto-Oncogene), located at 9q34.13 and 9q34.11, respectively. The fusion has been described as resulting from a recurrent cryptic deletion, del(9)(q34.11q34.13) and a chromosomal translocation, t(9;9)(q34;q34) [5,6]. In [[T-ALL| T-cell acute lymphoblastic leukemia]], the fusion has been shown to mediate elevated expression of [[HOXA| ''HOXA'']] cluster genes [7]. |
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| == Tumor Types == | | == Tumor Types == |
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− | [[T-ALL|T-cell Acute Lymphoblastic Leukemia]] | + | [[T-ALL|T-cell Acute Lymphoblastic Leukemia/Lymphoma]] |
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− | [[AML| Acute Myeloid Leukemia]] | + | [[AML| Acute Myeloid Leukemia]] (single case report) |
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| + | == Prevalence == |
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| + | Write your comments here |
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| + | == Genes Involved / Domains Affected == |
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| + | Write your comments here |
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| + | == Diagnostic Testing == |
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| + | Write your comments here |
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| + | == Clinical Significance == |
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| + | Write your comments here |
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| + | == Therapeutics == |
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| + | Write your comments here |
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| + | == Links == |
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| + | ==References== |
| <ref> Reference: Ann Clin Lab Sci. 2011 Summer;41(3):267-72. | | <ref> Reference: Ann Clin Lab Sci. 2011 Summer;41(3):267-72. |
| T-cell acute lymphoblastic leukemia associated with complex karyotype and SET-NUP214 rearrangement: a case study and review of the literature. | | T-cell acute lymphoblastic leukemia associated with complex karyotype and SET-NUP214 rearrangement: a case study and review of the literature. |
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| <ref> Characterization of the translocation breakpoint sequences of two DEK-CAN fusion genes present in t(6;9) acute myeloid leukemia and a SET-CAN fusion gene found in a case of acute undifferentiated leukemia. Genes Chromosomes Cancer. Von Lindern M, Breems D, van Baal S, Adriaansen H, Grosveld G. Genes Chromosomes Cancer. 1992;5:227–234. doi: 10.1002/gcc.2870050309. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1384675</ref> | | <ref> Characterization of the translocation breakpoint sequences of two DEK-CAN fusion genes present in t(6;9) acute myeloid leukemia and a SET-CAN fusion gene found in a case of acute undifferentiated leukemia. Genes Chromosomes Cancer. Von Lindern M, Breems D, van Baal S, Adriaansen H, Grosveld G. Genes Chromosomes Cancer. 1992;5:227–234. doi: 10.1002/gcc.2870050309. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1384675</ref> |
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| + | <ref> The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia. Van Vlierberghe, van Grotel M, Tchinda J, Lee C, Beverloo HB, van der Spek PJ, Stubbs A, Cools J, Nagata K, Fornerod M, Buijs-Gladdines J, Horstmann M, van Wering ER, Soulier J, Pieters R, Meijerink JP. Blood. 2008 May 1;111(9):4668-80. doi: 10.1182/blood-2007-09-111872. Epub 2008 Feb 25. PMID: http://www.ncbi.nlm.nih.gov/pubmed/18299449 </ref> |
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| Rare: <ref>B-cell Lymphoid Leukemia Test Reference: Oncol Lett. 2016 Apr;11(4):2644-2650. Epub 2016 Feb 23. | | Rare: <ref>B-cell Lymphoid Leukemia Test Reference: Oncol Lett. 2016 Apr;11(4):2644-2650. Epub 2016 Feb 23. |
| B-cell acute lymphoblastic leukemia associated with SET-NUP214 rearrangement: A case report and review of the literature. | | B-cell acute lymphoblastic leukemia associated with SET-NUP214 rearrangement: A case report and review of the literature. |
| Zhu HH1, Zhao XS1, Qin YZ1, Lai YY1, Jiang H1 PMID:[http://www.ncbi.nlm.nih.gov/pubmed/ 27073532] </ref> | | Zhu HH1, Zhao XS1, Qin YZ1, Lai YY1, Jiang H1 PMID:[http://www.ncbi.nlm.nih.gov/pubmed/ 27073532] </ref> |
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− | == Prevalence ==
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− | Write your comments here
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− | == Genes Involved / Domains Affected ==
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− | Write your comments here
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− | == Diagnostic Testing ==
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− | Write your comments here
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− | == Clinical Significance ==
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− | Write your comments here
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− | == Therapeutics ==
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− | Write your comments here
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− | == Links ==
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− | ==References==
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