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Renal Cell Neoplasia Tables: Recurrent Cytogenomic Alterations (view source)
Revision as of 17:48, 22 April 2021
, 17:48, 22 April 2021no edit summary
{{DISPLAYTITLE:Renal Table: Recurrent Genomic Alterations Detected by Chromosomal Microarray}}
{{DISPLAYTITLE:Renal Table: Recurrent Genomic Alterations Detected by Chromosomal Microarray}}
'''Table 1 - Recurrent Genomic Alterations in Renal Cell Neoplasias Detected by Chromosomal Microarray (Literature Review)'''. Genetic alterations and their associated clinical significance in major types of renal cell neoplasia. Table derived from Liu et al., 2020 [PMID 32434132] with permission from Cancer Genetics.
'''Table 1 - Recurrent Genomic Alterations in Renal Cell Neoplasia Detected by Chromosomal Microarray (Literature Review)'''. Genetic alterations and their associated clinical significance in major types of renal cell neoplasia. Table derived from Liu et al., 2020 [PMID 32434132] with permission from Cancer Genetics.
{| class="wikitable"
{| class="wikitable"
| colspan="8" |'''WHO Classification'''
| colspan="8" |'''WHO Classification'''
|15-20%
|15-20%
|15-20%
|15-20%
| colspan="2" | 1-5%
| colspan="2" |1-5%
| 5%
|5%
| 5%
|5%
|-
|-
|'''Origin'''
|'''Origin'''
|1p- (10%) [2; R]
|1p- (10%) [2; R]
|
|
| 1p- (25%) [2; R]
|1p- (25%) [2; R]
| colspan="2" |1p- (30%) [3; R]
| colspan="2" |1p- (30%) [3; R]
|'''-1''' (90%) '''[1; D]<sup>c</sup>'''
|'''-1''' (90%) '''[1; D]<sup>c</sup>'''
| colspan="8" |'''Mutations (SNVs, Indels) [level of evidence; clinical significance]'''
| colspan="8" |'''Mutations (SNVs, Indels) [level of evidence; clinical significance]'''
|-
|-
| Mutated
|Mutated
in >20%
in >20%
|
|
|-
|-
| Mutated
|Mutated
in 10-20%
in 10-20%
|Germline susceptibility
|Germline susceptibility
|
|
* mainly ''[[VHL]]'' (von Hippel-Lindau Syndrome)
*mainly ''[[VHL]]'' (von Hippel-Lindau Syndrome)
* ''[[PTEN]]'' (Cowden Syndrome)
*''[[PTEN]]'' (Cowden Syndrome)
* ''[[FLCN]]'' (Birt-Hogg-Dube syndrome)
*''[[FLCN]]'' (Birt-Hogg-Dube syndrome)
* ''[[TSC1]]'' and ''[[TSC2]]'' (tuberous sclerosis)
*''[[TSC1]]'' and ''[[TSC2]]'' (tuberous sclerosis)
* ''[[SDHB]] (most common), [[SDHC]] (less common), [[SDHA]] (rare), [[SDHD]] (rare)'' (succinate dehydrogenase deficient RCC)
*''[[SDHB]] (most common), [[SDHC]] (less common), [[SDHA]] (rare), [[SDHD]] (rare)'' (succinate dehydrogenase deficient RCC)
|
|
* ''[[MET]]'' (Hereditary papillary RCC)
*''[[MET]]'' (Hereditary papillary RCC)
|
|
* ''[[FH]]'' (Hereditary leiomyomatosis and RCC)
*''[[FH]]'' (Hereditary leiomyomatosis and RCC)
|
|
| colspan="2" |''[[FCLN]]'' (Birt-Hogg-Dube syndrome)
| colspan="2" |''[[FCLN]]'' (Birt-Hogg-Dube syndrome)