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Recurrent Genomic Alterations in Pediatric and Adult Central Nervous System Tumors Detected by Chromosomal Microarray (view source)
Revision as of 13:29, 16 November 2018
, 13:29, 16 November 2018no edit summary
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| Ganglioglioma
| Ganglioglioma
| Only 30% are abnormal by karyotype '''Gain:''' polysomy 7
| Only 30% are abnormal by karyotype <br>
'''Gain:''' polysomy 7
| '''Mutations:''' BRAF V600E in 20-60% of cases (can be concurrent with CDKN2A homozygous deletion)<br>
| '''Mutations:''' BRAF V600E in 20-60% of cases (can be concurrent with CDKN2A homozygous deletion)<br>
'''Fusions:''' KIAA1549-BRAF
'''Fusions:''' KIAA1549-BRAF
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| Pleomorphic xanthoastrocytoma (PXA)
| Pleomorphic xanthoastrocytoma (PXA)
| Polysomy 3, polysomy 7 observed; '''Loss:''' monosomy 9 / 9p deletion
| Polysomy 3, polysomy 7 observed<br>
'''Loss:''' monosomy 9 / 9p deletion
| '''Mutations:''' BRAF V600E in ~60%; TP53 (5%)<br>
| '''Mutations:''' BRAF V600E in ~60%; TP53 (5%)<br>
'''Loss:''' CDKN2A/CDKN2B
'''Loss:''' CDKN2A/CDKN2B
|IDH-mutant
|IDH-mutant
|'''Gain:''' 1q, 2q, 3q, 7, 16p, 17q, 21q<br>
|'''Gain:''' 1q, 2q, 3q, 7, 16p, 17q, 21q<br>
'''Loss:''' 6q, 8q, 9p, 9q, 10q, 13q, 17p, 22q
'''Loss:''' 6q, 8q, 9p, 9q, 10q, 13q, 17p, 22q<br>
''' Chromothripsis:''' observed
''' Chromothripsis:''' observed
|'''Loss:''' PTEN, RB1, TP53, CDKN2A/B/C
|'''Loss:''' PTEN, RB1, TP53, CDKN2A/B/C