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Line 1: − + − + − + − + − + − + − + − ! Clinical Significance+ − ! Level of Evidence+ + + + + + + + + − | 1
Recurrent Genomic Alterations in Pediatric and Adult Central Nervous System Tumors Detected by Chromosomal Microarray (view source)
Revision as of 12:57, 15 November 2018
, 12:57, 15 November 2018Adding CNS Tumor information
==Recurrent Genomic Alterations in AML Detected by Chromosomal Microarray (Literature Review)==
==Recurrent Genomic Alterations in Pediatric and Adult CNS Detected by Chromosomal Microarray (Literature Review)==
Table 1 - A comprehensive list of CNAs and CN-LOH detectable by CMA testing with strong diagnostic, prognostic and treatment implications in AML. Table derived from Xu et al., 2018 [PMID 30344013] with permission from Cancer Genetics.
Table 1 - Pediatric Central Nervous System Tumors. Table derived from Ligon et al., 2018 [ ] with permission from Cancer Genetics.
{| class="wikitable"
{| class="wikitable"
|-
|-
! Chromosome
! TUMOR
! AML Subtype
! SUBTYPES
! Abnormality Type (Amplification, Loss, CN-LOH)
! BROAD ABERRATIONS (>10Mb)
! Region
! FOCAL ABERRATIONS (>10Mb)
! Relevant Genes (if known)
! CLINICAL FEATURES
! REFERENCES
|-
! GLIOMAS
|-
| Low grade glioma, WHO grade I
| Pilocytic astrocytoma/pilomyxoid astrocytoma
| Some tumors show polysomy 7; other polysomies more common in adult PA
| '''Fusions:''' KIAA1549-BRAF fusion (via 3'BRAF duplication), other BRAF partners reported; NTRK fusions (rare); FGFR1 fusions (rare); '''Mutations:''' BRAF V600E (particularly extra-cerebellar tumors); FGFR1 (midline PA); NF1 (esp. germline), other MAPK pathway mutations '''Loss:''' NF1 in optic pathway PA
| Classic PA are cerebellar (most commonly associated with BRAF duplication); PA in patients with germline NF1 alterations often develop as optic gliomas;Surgical resection can be curative; PMA generally more aggressive than PA; BRAF fusions and BRAF mutations generally are mutually exclusive
| PMID:19016743; PMCID:2761618; PMID:18716556 PMID:25461780 PMID:25664944; PMID:26378811 PMCID:3429698; PMID:23817572; PMID:23583981 PMID:18974108; PMID:23278243; PMID:21274720
|-
|-
| AML including NK-AML
| AML including NK-AML
| CN-LOH
| CN-LOH