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Recurrent Genomic Alterations in Pediatric and Adult Central Nervous System Tumors Detected by Chromosomal Microarray
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==Recurrent Genomic Alterations in Pediatric and Adult CNS Detected by Chromosomal Microarray
(Literature Review)==
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==Recurrent Genomic Alterations in Pediatric and Adult CNS Detected by Chromosomal Microarray
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Table 1 - Pediatric Central Nervous System Tumors. Table derived from
Ligon et al.,
2018
[ ] with permission from Cancer Genetics
.
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Table 1 - Pediatric Central Nervous System Tumors. Table derived from
CGC CNS Workgroup
2018.
{| class="wikitable"
{| class="wikitable"
|-
|-
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| Generally indolent tumors for which surgical resection can be curative
| Generally indolent tumors for which surgical resection can be curative
| PMID:25461780; PMID:23583981; PMID:11996800 PMID:23609006; PMID:29880043
| PMID:25461780; PMID:23583981; PMID:11996800 PMID:23609006; PMID:29880043
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|-
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|Low grade glioma, WHO grade II
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|Diffuse astrocytoma
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|No diagnostic aberrations
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| '''Rearrangement:''' MYBL1 truncating rearrangements and tandem duplication, FGFR1 rearrangements; '''Mutation:''' FGFR1
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| Anaplastic features associated with decreased progression free survival
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| PMID:25664944; PMID:23633565; PMID:26061751 PMID:26824661; PMID:26004297; PMID:25461780 PMID:23583981
|-
|-
|
|
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| Pleomorphic xanthoastrocytoma (PXA)
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| Polysomy 3, polysomy 7 observed; '''Loss:''' monosomy 9 / 9p deletion
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| '''Mutations:''' BRAF V600E in ~60%; TP53 (5%); '''Loss:''' CDKN2A/CDKN2B
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|
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| PMID:25461780; PMID:23583981; PMID:16909113; PMID:12484572
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|-
Jennifer.Hauenstein
31
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