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Recurrent Genomic Alterations in Pediatric and Adult Central Nervous System Tumors Detected by Chromosomal Microarray (view source)
Revision as of 14:15, 15 November 2018
, 14:15, 15 November 2018no edit summary
==Recurrent Genomic Alterations in Pediatric and Adult CNS Detected by Chromosomal Microarray (Literature Review)==
==Recurrent Genomic Alterations in Pediatric and Adult CNS Detected by Chromosomal Microarray
Table 1 - Pediatric Central Nervous System Tumors. Table derived from Ligon et al., 2018 [ ] with permission from Cancer Genetics.
Table 1 - Pediatric Central Nervous System Tumors. Table derived from CGC CNS Workgroup 2018.
{| class="wikitable"
{| class="wikitable"
|-
|-
| Generally indolent tumors for which surgical resection can be curative
| Generally indolent tumors for which surgical resection can be curative
| PMID:25461780; PMID:23583981; PMID:11996800 PMID:23609006; PMID:29880043
| PMID:25461780; PMID:23583981; PMID:11996800 PMID:23609006; PMID:29880043
|-
|Low grade glioma, WHO grade II
|Diffuse astrocytoma
|No diagnostic aberrations
| '''Rearrangement:''' MYBL1 truncating rearrangements and tandem duplication, FGFR1 rearrangements; '''Mutation:''' FGFR1
| Anaplastic features associated with decreased progression free survival
| PMID:25664944; PMID:23633565; PMID:26061751 PMID:26824661; PMID:26004297; PMID:25461780 PMID:23583981
|-
|-
|
|
| Pleomorphic xanthoastrocytoma (PXA)
| Polysomy 3, polysomy 7 observed; '''Loss:''' monosomy 9 / 9p deletion
| '''Mutations:''' BRAF V600E in ~60%; TP53 (5%); '''Loss:''' CDKN2A/CDKN2B
|
| PMID:25461780; PMID:23583981; PMID:16909113; PMID:12484572
|-