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'''[http://www.ccga.io/index.php/Acute_Myeloid_Leukemia_(AML)_with_t(8;21)(q22;q22.1);_RUNX1-RUNX1T1 Acute Myeloid Leukemia (AML) with t(8;21)(q22;q22.1); RUNX1-RUNX1T1]'''

'''[http://www.ccga.io/index.php/Acute_Myeloid_Leukemia_(AML)_with_t(8;21)(q22;q22.1);_RUNX1-RUNX1T1 Acute Myeloid Leukemia (AML) with t(8;21)(q22;q22.1); RUNX1-RUNX1T1]'''

The t(8;21)(q22;q22), resulting in fusion of ''RUNXT1'' and ''RUNX1'', is one of the most frequent karyotypic abnormalities in acute myeloid leukemia with a reported incidence of 7% [5,7].  The t(8;21)(q22;q22.1)produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 (''RUNX1'') gene fused to the 3'-region of the ''RUNX1T1'' gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.

The t(8;21)(q22;q22.1), resulting in fusion of ''RUNXT1'' and ''RUNX1'', is one of the most frequent karyotypic abnormalities in acute myeloid leukemia with a reported incidence of 7% [5,7].  The t(8;21)(q22;q22.1) produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 (''RUNX1'') gene fused to the 3'-region of the ''RUNX1T1'' gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.

==Gene Overview==

==Gene Overview==