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Plasma Cell Neoplasms Tables: Recurrent Cytogenomic Alterations (view source)
Revision as of 14:52, 13 July 2020
, 14:52, 13 July 2020added intro and legend
'''Table 1 - Recurrent Abnormalities of copy number aberration (CNAs) and copy-neutral loss-of-heterozygosity (cnLOH) in plasma cell myeloma (Literature Review)'''. Summary table reviewing 65 papers applying FISH, CMA, NGS, and gene expression profiling for PCN diagnosis and prognosis. Table derived from Pugh et al., 2018 [PMID 30393007] with permission from Cancer Genetics.
{| class="wikitable"
{| class="wikitable"
|'''Chromosome'''
|'''Chromosome'''
|Recurrent
|Recurrent
|2
|2
|24987674 (2014)<ref name=":1" /> 25145975 (2015)<ref name=":2" />
|24987674 (2014)<ref name=":1" /> 25145975 (2015)<ref name=":2" />
|-
|-
|5q13.2
|5q13.2
|Recurrent
|Recurrent
|2
|2
|24987674 (2014)<ref name=":1" />, 25145975 (2015)<ref name=":2" />
|24987674 (2014)<ref name=":1" />, 25145975 (2015)<ref name=":2" />
|-
|-
|9q
|9q
|Recurrent
|Recurrent
|1
|1
|24987674 (2014)<ref name=":1" />, 25145975 (2015)<ref name=":2" />, 24757046 (2014)<ref name=":5" />, 23010713 (2012)<ref name=":6" />, 22833442 (2012)<ref name=":7" />,
|24987674 (2014)<ref name=":1" />, 25145975 (2015)<ref name=":2" />, 24757046 (2014)<ref name=":5" />, 23010713 (2012)<ref name=":6" />, 22833442 (2012)<ref name=":7" />,
|-
|-
|15q24.1
|15q24.1
|Recurrent
|Recurrent
|2
|2
|25145975 (2015)<ref name=":2" />, 22833442 (2012)<ref name=":7" />
|25145975 (2015)<ref name=":2" />, 22833442 (2012)<ref name=":7" />
|-
|-
|X
|X
|27811368-(2016)<ref name=":9" />
|27811368-(2016)<ref name=":9" />
|}
|}
<references />
cnLOH = copy neutral LOH, LOH = Loss of Heterozygosity, GEP = Gene Expression Profile
'''Level of evidence:'''
Level 1: well established evidence (in NCCN guideline, WHO criteria, FDA-approved, COG recommendation, or based on large body of publications)
Level 2: emerging evidence (by one large study or multiple case reports)
Level 3: presumptive evidence (multiple case reports or expert opinion)<references />