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PML (view source)

Revision as of 12:00, 30 July 2018

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→‎Cancer Category/Type

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==Cancer Category/Type==

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Acute Promyelocytic Leukemia (APL)

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(90% to 95%) of the cases, APL results from a t (15;17) (q22;q21) translocation resulting in the head to tail fusion of the promyelocytic leukemia (PML) gene, to RAR-alpha to generate two fusion genes, PML-RARalpha and a reciprocal RAR-alpha-PML (80%) that encode a protein, which functions as an aberrant retinoid receptor [3].

==Gene Overview==

Brian.Davis

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