Changes

==Primary Author(s)*==

==Primary Author(s)*==

 

__TOC__

__TOC__

==Synonyms==

==Synonyms==

 

==Genomic Location==

==Genomic Location==

'''Cytoband:''' Put your text here. EXAMPLE: 17p13.1

'''Cytoband:''' 15q24.1

'''Genomic Coordinates:'''  

'''Genomic Coordinates:'''  

EXAMPLE: chr17:7,571,720-7,590,868 [hg19]

chr15:73,994,673-74,047,819(GRCh38/hg38)

 

EXAMPLE: chr17:7,668,402-7,687,538 [hg38]

==Cancer Category/Type==

==Cancer Category/Type==

==Gene Overview==

==Gene Overview==

Put your text here.

localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL).

==Common Alteration Types==

==Common Alteration Types==

EXAMPLES

EXAMPLES

'''[http://atlasgeneticsoncology.org/Genes/P53ID88.html ''TP53'' by Atlas of Genetics and Cytogenetics in Oncology and Haematology]''' - detailed gene information

'''[http://http://atlasgeneticsoncology.org//Genes/PMLID41.html ''PML'' by Atlas of Genetics and Cytogenetics in Oncology and Haematology]''' - detailed gene information

'''[https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=TP53 ''TP53'' by COSMIC]''' - sequence information, expression, catalogue of mutations

'''[https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=pml ''PML'' by COSMIC]''' - sequence information, expression, catalogue of mutations

'''[https://civicdb.org/events/genes/45/summary/variants/1300/summary ''TP53'' by CIViC]''' - general knowledge and evidence-based variant specific information

'''[https://civicdb.org/events/genes/39/summary/variants/108/summary ''PML-RARA'' by CIViC]''' - general knowledge and evidence-based variant specific information

'''[http://p53.iarc.fr/ ''TP53'' by IARC]''' - ''TP53'' database with reference sequences and mutational landscape

'''[https://pecan.stjude.cloud/proteinpaint/pml ''PML'' by St. Jude ProteinPaint]''' mutational landscape and matched expression data.

'''[https://pecan.stjude.cloud/proteinpaint/tp53 ''TP53'' by St. Jude ProteinPaint]''' mutational landscape and matched expression data.

'''[https://pmkb.weill.cornell.edu/search?utf8=%E2%9C%93&search=pml ''PML'' by Precision Medicine Knowledgebase (Weill Cornell)]''' - manually vetted interpretations of variants and CNVs

'''[https://pmkb.weill.cornell.edu/search?utf8=%E2%9C%93&search=tp53 ''TP53'' by Precision Medicine Knowledgebase (Weill Cornell)]''' - manually vetted interpretations of variants and CNVs

'''[http://www.cancerindex.org/geneweb/PML.htm ''PML'' by Cancer Index]''' - gene, pathway, publication information matched to cancer type

'''[http://www.cancerindex.org/geneweb/TP53.htm ''TP53'' by Cancer Index]''' - gene, pathway, publication information matched to cancer type

'''[http://oncokb.org/#/gene/pml ''PML'' by OncoKB]''' - mutational landscape, mutation effect, variant classification

'''[http://oncokb.org/#/gene/TP53 ''TP53'' by OncoKB]''' - mutational landscape, mutation effect, variant classification

'''[https://www.mycancergenome.org/content/gene/pml/ ''PML'' by My Cancer Genome]''' - brief gene overview

'''[http://www.uniprot.org/uniprot/P29590 ''PML'' by UniProt]''' - protein and molecular structure and function

 

'''[http://www.uniprot.org/uniprot/P04637 ''TP53'' by UniProt]''' - protein and molecular structure and function

'''[https://pfam.xfam.org/family/p53 ''TP53'' by Pfam]''' - gene and protein structure and function information

'''[https://pfam.xfam.org/family/p53 ''TP53'' by Pfam]''' - gene and protein structure and function information

'''[http://www.genecards.org/cgi-bin/carddisp.pl?gene=tp53 ''TP53'' by GeneCards]''' - general gene information and summaries

'''[http://www.genecards.org/cgi-bin/carddisp.pl?gene=pml ''PML'' by GeneCards]''' - general gene information and summaries

'''[https://www.ncbi.nlm.nih.gov/books/NBK1311/ GeneReviews]''' - information on Li Fraumeni Syndrome

'''[https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=full_report&list_uids=5371 "PML" by NCBI Gene]''' - general gene information and summaries

==References==

==References==

1. Arber DA, et al., (2008). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, Editors. IARC Press: Lyon, France, p117-118.

#Arber DA, et al., (2008). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, Editors. IARC Press: Lyon, France, p117-118.

 

#Li Y, et al., (2001). Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 28:220-221, PMID 11431691.

== Notes ==

== Notes ==

<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page.  If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage).  Additional global feedback or concerns are also welcome.

<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page.  If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage).  Additional global feedback or concerns are also welcome.