43
edits
Changes
MDS, MDS/MPN and MPN Tables: Recurrent Genomic Alterations Detected by Chromosomal Microarray (view source)
Revision as of 10:19, 6 January 2020
, 10:19, 6 January 2020citations
|''CBL''
|''CBL''
|Recurrent
|Recurrent
|<ref name=":13" /><ref name=":33" /><ref name=":10" /><ref name=":5" />44]
|<ref name=":13" /><ref name=":33" /><ref name=":10" /><ref name=":5" /><ref name=":34">Gondek LP, Dunbar AJ, Szpurka H, McDevitt MA, Maciejewski JP. SNP array karyotyping allows for the detection of uniparental disomy and cryptic chromosomal abnormalities in MDS/MPD-U and MPD. PLoS One 2007;2:e1225. [https://www.ncbi.nlm.nih.gov/pubmed/18030353]</ref>
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|-
|MPN
|MPN
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|
|Recurrent
|Recurrent
|[40, 55, 56]
|<ref>Singh NR, Morris CM, Koleth M, Wong K, Ward CM, Stevenson WS. Polyploidy in myelofibrosis: analysis by cytogenetic and SNP array indicates association with advancing disease. Mol Cytogenet 2013;6:59.[https://www.ncbi.nlm.nih.gov/pubmed/24341401]</ref>56]
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|-
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|''JAK2''
|''JAK2''
|Predictive for JAK2 inhibitors; Prognostic for PV progression to MF
|Predictive for JAK2 inhibitors; Prognostic for PV progression to MF
|[40, 44, 55, 56, 113]
|<ref name=":35">Rumi E, Harutyunyan A, Elena C, Pietra D, Klampfl T, Bagienski K, et al. Identification of genomic aberrations associated with disease transformation by means of high-resolution SNP array analysis in patients with myeloproliferative neoplasm. Am J Hematol 2011;86:974-9.[https://www.ncbi.nlm.nih.gov/pubmed/21953568]</ref><ref name=":34" /><ref name=":35" />56, 113]
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|-
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|Presence of CNAs/CN-LOH prognostic for progression to AML
|Presence of CNAs/CN-LOH prognostic for progression to AML
|[40, 55, 56<ref name=":6" />
|<ref name=":35" /><ref name=":35" />56<ref name=":6" />
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|-
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|
|
|Recurrent
|Recurrent
|[40, 55, 114]
|<ref name=":35" />114]
|-
|-
|CML
|CML
|P (Intermediate)
|P (Intermediate)
|1
|1
|[23, 28<ref name=":20" />44, 56<ref name=":21" />
|[23, 28<ref name=":20" /><ref name=":34" />56<ref name=":21" />
|-
|-
|7
|7
|P (Poor)
|P (Poor)
|1
|1
|<ref name=":13" />44]
|<ref name=":13" /><ref name=":34" />
|-
|-
|7
|7
|P (Intermediate)
|P (Intermediate)
|1
|1
|[44, 56]
|<ref name=":34" />56]
|-
|-
|14
|14
|P (Intermediate)
|P (Intermediate)
|2
|2
|[44]
|<ref name=":34" />
|-
|-
|21
|21
|Recurrent
|Recurrent
|2
|2
|[40]
|<ref name=":35" />
|-
|-
|1
|1
|Recurrent
|Recurrent
|2
|2
|[40, 55, 56]
|<ref name=":35" /><ref name=":35" />56]
|-
|-
|4
|4
|P (Poor)
|P (Poor)
|1
|1
|[40]
|<ref name=":35" />
|-
|-
|7
|7
|Recurrent
|Recurrent
|2
|2
|[40, 55, 56]
|<ref name=":35" /><ref name=":35" />56]
|-
|-
|9
|9
|Recurrent
|Recurrent
|2
|2
|[40, 44] [55] [56, 113]
|<ref name=":35" /><ref name=":34" /><ref name=":35" />56, 113]
|-
|-
|9
|9
|Recurrent
|Recurrent
|2
|2
|[40, 55]
|<ref name=":35" /><ref name=":35" />
|-
|-
|12
|12
|Recurrent
|Recurrent
|1
|1
|[55]
|<ref name=":35" />
|-
|-
|14
|14
|Recurrent
|Recurrent
|3
|3
|[40, 55, 56<ref name=":6" />
|<ref name=":35" /><ref name=":35" />56<ref name=":6" />
|-
|-
|17
|17
|P (Poor)
|P (Poor)
|1
|1
|[51, 52, 55]
|[51, 52<ref name=":35" />
|-
|-
|20
|20
|Recurrent
|Recurrent
|1
|1
|[40, 55, 114]
|<ref name=":35" />114]
|-
|-
|22
|22