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==References==
 
==References==
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=== EXAMPLE Book ===
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1. Jennings, G. T. et al. Cytosolic NADP (+)-dependent isocitrate dehydrogenase. Isolation of rat cDNA and study of tissue-specific and developmental expression of mRNA. J. Biol. Chem. 269, 23128–23134 (1994). PMID: 8083215
#Arber DA, et al., (2008). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, Editors. IARC Press: Lyon, France, p117-118.
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=== EXAMPLE Journal Article ===
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2. Luo, H., Shan, X. & Wu, J. Expression of human mitochondrial NADP‐dependent isocitrate dehydrogenase during lymphocyte activation. J. Cell. Biochem. 60, 495–507 (1996). PMID: 8707889
#Li Y, et al., (2001). Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 28:220-221, PMID 11431691.
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3. Nekrutenko, A., Hillis, D. M., Patton, J. C., Bradley, R. D. & Baker, R. J. Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family. Mol. Biol. Evol. 15, 1674–1684 (1998). PMID: 9866202
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4. Ceccarelli, C., Grodsky, N. B., Ariyaratne, N., Colman, R. F. & Bahnson, B. J. Crystal Structure of Porcine Mitochondrial NADP+-dependent Isocitrate Dehydrogenase Complexed with Mn2+ and Isocitrate. INSIGHTS INTO THE ENZYME MECHANISM. J. Biol. Chem. 277, 43454–43462 (2002). PMID: 12207025
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5. Ward, P. S. et al. The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate. Cancer Cell 17, 225–234 (2010). PMID: 20171147
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6. Comte, B., Vincent, G., Bouchard, B., Benderdour, M. & Des Rosiers, C. Reverse flux through cardiac NADP + -isocitrate dehydrogenase under normoxia and ischemia. Am. J. Physiol.-Heart Circ. Physiol. 283, H1505–H1514 (2002). PMID: 12234803
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7. Sazanov, L. A. & Jackson, J. B. Proton-translocating transhydrogenase and NAD- and NADP-linked isocitrate dehydrogenases operate in a substrate cycle which contributes to fine regulation of the tricarboxylic acid cycle activity in mitochondria. FEBS Lett. 344, 109–116 (1994). PMID: 8187868
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8. Reitman, Z. J. & Yan, H. Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism. JNCI J. Natl. Cancer Inst. 102, 932–941 (2010). PMID: 20513808
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9. Mailloux, R. J. et al. The Tricarboxylic Acid Cycle, an Ancient Metabolic Network with a Novel Twist. PLoS ONE 2, e690 (2007). PMID: 17668068
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10. Lee, S. M. et al. Cytosolic NADP+-dependent isocitrate dehydrogenase status modulates oxidative damage to cells. Free Radic. Biol. Med. 32, 1185–1196 (2002). PMID: 12031902
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11. Lee, S. ‐H. et al. Role of NADP+‐dependent isocitrate dehydrogenase (NADP+‐ICDH) on cellular defence against oxidative injury by γ‐rays. Int. J. Radiat. Biol. 80, 635–642 (2004). PMID: 15586883
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12. Lee, J. H., Kim, S. Y., Kil, I. S. & Park, J.-W. Regulation of Ionizing Radiation-induced Apoptosis by Mitochondrial NADP + -dependent Isocitrate Dehydrogenase. J. Biol. Chem. 282, 13385–13394 (2007). PMID: 17350954
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13. Shin, S. W., Kil, I. S. & Park, J.-W. Silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase by small interfering RNA enhances heat shock-induced apoptosis. Biochem. Biophys. Res. Commun. 366, 1012–1018 (2008). PMID: 18096511
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14. Kil, I. S., Kim, S. Y., Lee, S. J. & Park, J.-W. Small interfering RNA-mediated silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase enhances the sensitivity of HeLa cells toward tumor necrosis factor-α and anticancer drugs. Free Radic. Biol. Med. 43, 1197–1207 (2007). PMID: 17854715
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15. Kranendijk, M. et al. IDH2 mutations in patients with D-2-hydroxyglutaric aciduria. Science 330, 336 (2010). PMID: 20847235
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16. Yan, H. et al. IDH1 and IDH2 mutations in gliomas. N. Engl. J. Med. 360, 765–773 (2009). PMID: 23532369
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17. Hartmann, C. et al. Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas. Acta Neuropathol. (Berl.) 118, 469–474 (2009). PMID: 19554337
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18. Amary, M. F. et al. IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours. J. Pathol. 224, 334–343 (2011). PMID: 21598255
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19. Borger, D. R. et al. Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping. The Oncologist 17, 72–79 (2012). PMID: 22180306
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20. Houillier, C. et al. IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas. Neurology 75, 1560–1566 (2010). PMID: 20975057
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21. Lugowska, I. et al. IDH1/2 Mutations Predict Shorter Survival in Chondrosarcoma. J. Cancer 9, 998–1005 (2018). PMID: 29581779
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22. Figueroa, M. E. et al. Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation. Cancer Cell 18, 553–567 (2010). PMID: 21130701
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23. Green, C. L. et al. The prognostic significance of IDH2 mutations in AML depends on the location of the mutation. Blood 118, 409–412 (2011). PMID: 21596855
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24. Chou, W.-C. et al. The prognostic impact and stability of Isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia. Leukemia 25, 246–253 (2011). PMID: 21079611
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25. Aref, S. et al. Prevalence and Clinical Effect of IDH1 and IDH2 Mutations Among Cytogenetically Normal Acute Myeloid Leukemia Patients. Clin. Lymphoma Myeloma Leuk. 15, 550–555 (2015). PMID: 26189213
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26. Yamaguchi, S. et al. IDH1 and IDH2 mutations confer an adverse effect in patients with acute myeloid leukemia lacking the NPM1 mutation. Eur. J. Haematol. 92, 471–477 (2013). PMID: 24443894
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27. Cairns, R. A. et al. IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma. Blood 119, 1901–1903 (2012). PMID: 22215888
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28. Wang, C. et al. IDH2R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma. Blood 126, 1741–1752 (2015). PMID: 26268241
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29. Soundar, S., Danek, B. L. & Colman, R. F. Identification by Mutagenesis of Arginines in the Substrate Binding Site of the Porcine NADP-dependent Isocitrate Dehydrogenase. J. Biol. Chem. 275, 5606–5612 (2000). PMID: 10681542
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30. Gross, S. et al. Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations. J. Exp. Med. 207, 339–344 (2010). PMID: 20142433
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31. Grassian, A. R. et al. IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism. Cancer Res. 74, 3317–3331 (2014). PMID: 24755473
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32. Chan, S. M. et al. Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia. Nat. Med. 21, 178–184 (2015). PMID: 25599133
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33. Lu, C. et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature 483, 474–478 (2012). PMID: 22343901
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34. Xu, W. et al. Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases. Cancer Cell 19, 17–30 (2011). PMID: 26686626
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35. Sulkowski, P. L. et al. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity. Sci. Transl. Med. 9, eaal2463 (2017). PMID: 28148839
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36. Molenaar, R. J. et al. IDH1/2 Mutations Sensitize Acute Myeloid Leukemia to PARP Inhibition and This Is Reversed by IDH1/2-Mutant Inhibitors. Clin. Cancer Res. 24, 1705–1715 (2018). PMID: 29339439
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37. Saha, S. K. et al. Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. Cancer Discov. 6, 727–739 (2016). PMID: 27231123
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38. Li, S. et al. Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation. Neuro-Oncol. 15, 57–68 (2013). PMID: 23115158
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39. Stein, E. M. et al. Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia. Blood 130, 722–731 (2017). PMID: 28588020
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40. Konopleva, M. et al. Efficacy and Biological Correlates of Response in a Phase II Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia. Cancer Discov. 6, 1106–1117 (2016). PMID: 27520294
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41. Tateishi, K. et al. Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion. Cancer Cell 28, 773–784 (2015). PMID: 26678339
    
== Notes ==
 
== Notes ==
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