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81. SongTao Q, et al., (2012). IDH mutations predict longer survival and response to temozolomide in secondary glioblastoma. Cancer Sci 103:269–273, PMID 22034964.  
 
81. SongTao Q, et al., (2012). IDH mutations predict longer survival and response to temozolomide in secondary glioblastoma. Cancer Sci 103:269–273, PMID 22034964.  
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82. Molenaar, R. J. et al. IDH1/2 Mutations Sensitize Acute Myeloid Leukemia to PARP Inhibition and This Is Reversed by IDH1/2-Mutant Inhibitors. Clin. Cancer Res. 24, 1705–1715 (2018). PMID: 29339439  
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82. Molenaar RJ, et al., (2018). IDH1/2 mutations sensitize acute myeloid leukemia to PARP inhibition and this is reversed by IDH1/2-mutant inhibitors. Clin Cancer Res 24:1705–1715, PMID 29339439.
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83. Lu, Y. et al. Chemosensitivity of IDH1-Mutated Gliomas Due to an Impairment in PARP1-Mediated DNA Repair. Cancer Res. 77, 1709–1718 (2017). PMID: 28202508  
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83. Lu Y, et al., (2017). Chemosensitivity of IDH1-mutated gliomas due to an impairment in PARP1-mediated DNA repair. Cancer Res 77:1709–1718, PMID 28202508.
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84. Popovici-Muller, J. et al. Discovery of the first potent inhibitors of mutant IDH1 that lower tumor 2-HG in vivo. ACS Med. Chem. Lett. 3, 850–855 (2012). PMID: 24900389  
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84. Popovici-Muller J, et al., (2012). Discovery of the first potent inhibitors of mutant IDH1 that lower tumor 2-HG in vivo. ACS Med Chem Lett 3:850–855, PMID 24900389.
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85. Popovici-Muller, J. et al. Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers. ACS Med. Chem. Lett. 9, 300–305 (2018). PMID: 29670690  
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85. Popovici-Muller J, et al., (2018). Discovery of AG-120 (ivosidenib): a first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers. ACS Med Chem Lett 9:300–305, PMID 29670690.
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86. Rohle, D. et al. An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells. Science 340, 626–630 (2013). PMID: 23558169  
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86. Rohle D, et al., (2013). An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science 340:626–630, PMID 23558169.
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87. Li, L. et al. Treatment with a Small Molecule Mutant IDH1 Inhibitor Suppresses Tumorigenic Activity and Decreases Production of the Oncometabolite 2-Hydroxyglutarate in Human Chondrosarcoma Cells. PLOS ONE 10, e0133813 (2015). PMID: 26368816  
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87. Li L, et al., (2015). Treatment with a small molecule mutant IDH1 inhibitor suppresses tumorigenic activity and decreases production of the oncometabolite 2-Hydroxyglutarate in human chondrosarcoma cells. PLOS ONE 10:e0133813, PMID 26368816.
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88. Birendra, K. C. & DiNardo, C. D. Evidence for Clinical Differentiation and Differentiation Syndrome in Patients With Acute Myeloid Leukemia and IDH1 Mutations Treated With the Targeted Mutant IDH1 Inhibitor, AG-120. Clin. Lymphoma Myeloma Leuk. 16, 460–465 (2016). PMID: 27245312
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88. Birendra KC and DiNardo CD, (2016). Evidence for clinical differentiation and differentiation syndrome in patients with acute myeloid leukemia and IDH1 mutations treated with the targeted mutant IDH1 inhibitor, AG-120. Clin Lymphoma Myeloma Leuk 16:460–465, PMID 27245312.
    
== Notes ==
 
== Notes ==