''TP53'' mutations have been associated with ''IDH1''-mutated astrocytoma and glioblastoma more than with other glioma subtypes [20,59], and astrocytomas are thought to develop via ''TP53'' and ''ATRX'' mutations subsequent to ''IDH1'' mutations. Astrocytomas associated with germline ''TP53'' mutations were found to have somatic ''IDH1'' Arg123Cys (NM_005896.2/NP_005887.2) mutations which are otherwise rare in this malignancy, suggesting the preferential occurrence of this specific mutation in cells that already contain a ''TP53'' mutation [60]. | ''TP53'' mutations have been associated with ''IDH1''-mutated astrocytoma and glioblastoma more than with other glioma subtypes [20,59], and astrocytomas are thought to develop via ''TP53'' and ''ATRX'' mutations subsequent to ''IDH1'' mutations. Astrocytomas associated with germline ''TP53'' mutations were found to have somatic ''IDH1'' Arg123Cys (NM_005896.2/NP_005887.2) mutations which are otherwise rare in this malignancy, suggesting the preferential occurrence of this specific mutation in cells that already contain a ''TP53'' mutation [60]. |