Changes

45. Tateishi K, et al., (2015). Extreme vulnerability of IDH1 mutant cancers to NAD+ depletion. Cancer Cell 28:773–784, PMID 26678339.  

45. Tateishi K, et al., (2015). Extreme vulnerability of IDH1 mutant cancers to NAD+ depletion. Cancer Cell 28:773–784, PMID 26678339.  

46. Chen, F. et al. Oncometabolites D - and L -2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions. Chem. Res. Toxicol. 30, 1102–1110 (2017). PMID: 28269980  

46. Chen F, et al., (2017). Oncometabolites D - and L -2-Hydroxyglutarate inhibit the AlkB family DNA repair enzymes under physiological conditions. Chem Res Toxicol 30:1102–1110, PMID 28269980.

47. Sulkowski, P. L. et al. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity. Sci. Transl. Med. 9, eaal2463 (2017). PMID: 28148839  

47. Sulkowski PL, et al., (2017). 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity. Sci Transl Med 9:eaal2463, PMID 28148839.

48. Inoue, S. et al. Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2. Cancer Cell 30, 337–348 (2016). PMID: 27424808  

48. Inoue S, et al., (2016). Mutant IDH1 downregulates ATM and alters DNA repair and sensitivity to DNA damage independent of TET2. Cancer Cell 30:337–348, PMID 27424808.

49. Noushmehr, H. et al. Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma. Cancer Cell 17, 510–522 (2010). PMID: 20399149  

49. Noushmehr H,et al., (201). Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 17:510–522, PMID 20399149.

50. Figueroa, M. E. et al. Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation. Cancer Cell 18, 553–567 (2010). PMID: 21130701  

50. Figueroa ME, et al., (2010). Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 18:553–567, PMID 21130701.

51. Turcan, S. et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature 483, 479–483 (2012). PMID: 22343889  

51. Turcan S, et al., (2012). IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature 483:479–483, PMID 22343889.

52. Losman, J.-A. & Kaelin, W. G. What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer. Genes Dev. 27, 836–852 (2013). PMID: 23630074  

52. Losman J-A and Kaelin WG, (2013). What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer. Genes Dev 27:836–852, PMID 23630074.

53. Tönjes, M. et al. BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1. Nat. Med. 19, 901–908 (2013). PMID: 23793099

53. Tönjes M, et al., (2013). BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1. Nat Med 19:901–908, PMID 23793099.

54. Molenaar, R. J. et al. Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198. Cancer Res. 75, 4790–4802 (2015). PMID: 26363012  

54. Molenaar RJ, et al., (2015). Radioprotection of IDH1-mutated cancer cells by the IDH1-mutant inhibitor AGI-5198. Cancer Res 75:4790–4802, PMID 26363012.

55. Shi, J. et al. Decreasing GSH and increasing ROS in chemosensitivity gliomas with IDH1 mutation. Tumor Biol. 36, 655–662 (2015). PMID: 25283382  

55. Shi J, et al., (2015). Decreasing GSH and increasing ROS in chemosensitivity gliomas with IDH1 mutation. Tumor Biol 36:655–662, PMID 25283382.

56. Molenaar, R. J., Radivoyevitch, T., Maciejewski, J. P., van Noorden, C. J. & Bleeker, F. E. The driver and passenger effects of isocitrate dehydrogenase 1 and 2 mutations in oncogenesis and survival prolongation. Biochim. Biophys. Acta BBA-Rev. Cancer 1846, 326–341 (2014). PMID: 24880135  

56. Molenaar RJ, et al., (2014). The driver and passenger effects of isocitrate dehydrogenase 1 and 2 mutations in oncogenesis and survival prolongation. Biochim Biophys Acta BBA-Rev Cancer 1846:326–341, PMID 24880135.

57. Gilbert, M. R. et al. Autophagy and oxidative stress in gliomas with IDH1 mutations. Acta Neuropathol. (Berl.) 127, 221–233 (2014). PMID: 24150401  

57. Gilbert MR, et al., (2014). Autophagy and oxidative stress in gliomas with IDH1 mutations. Acta Neuropathol (Berl) 127:221–233, PMID 24150401.

58. Ohgaki, H. & Kleihues, P. Genetic alterations and signaling pathways in the evolution of gliomas. Cancer Sci. 100, 2235–2241 (2009). PMID: 19737147  

58. Ohgaki H and Kleihues P, (2009). Genetic alterations and signaling pathways in the evolution of gliomas. Cancer Sci 100:2235–2241, PMID 19737147.

59. Watanabe, T., Nobusawa, S., Kleihues, P. & Ohgaki, H. IDH1 Mutations Are Early Events in the Development of Astrocytomas and Oligodendrogliomas. Am. J. Pathol. 174, 1149–1153 (2009). PMID: 19246647

59. Watanabe T, et al., (2009). IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas. Am J Pathol 174:1149–1153, PMID 19246647.

60. Watanabe, T., Vital, A., Nobusawa, S., Kleihues, P. & Ohgaki, H. Selective acquisition of IDH1 R132C mutations in astrocytomas associated with Li-Fraumeni syndrome. Acta Neuropathol. (Berl.) 117, 653–656 (2009). PMID: 19340432  

60. Watanabe T, et al., (2009). Selective acquisition of IDH1 R132C mutations in astrocytomas associated with Li-Fraumeni syndrome. Acta Neuropathol (Berl) 117:653–656, PMID 19340432.

61. The Cancer Genome Atlas Research Network. Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N. Engl. J. Med. 372, 2481–2498 (2015). PMID: 26061751  

61. The Cancer Genome Atlas Research Network. Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N. Engl. J. Med. 372, 2481–2498 (2015). PMID: 26061751