Changes

30. Jiao Y, et al., (2013). Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas. Nat Genet 45:1470–1473, PMID 24185509.  

30. Jiao Y, et al., (2013). Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas. Nat Genet 45:1470–1473, PMID 24185509.  

31. Mardis, E. R. et al. Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome. N. Engl. J. Med. 361, 1058–1066 (2009). PMID: 19657110  

31. Mardis ER, et al., (2009). Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 361:1058–1066, PMID 19657110.

32. Xu, Q. et al. Correlation Between Isocitrate Dehydrogenase Gene Aberrations and Prognosis of Patients with Acute Myeloid Leukemia: A Systematic Review and Meta-Analysis. Clin. Cancer Res. 23, 4511–4522 (2017). PMID: 28246275  

32. Xu Q, et al., (2017. Correlation between isocitrate dehydrogenase gene aberrations and prognosis of patients with acute myeloid leukemia: a systematic review and meta-analysis. Clin Cancer Res 23:4511–4522, PMID 28246275.

33. Schnittger, S. et al. IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status. Blood 116, 5486–5496 (2010). PMID: 20805365  

33. Schnittger S, et al., (2010). IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status. Blood 116:5486–5496, PMID 20805365.

34. Patnaik, M. M. et al. Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic Study of 277 patients. Leukemia 26, 101–105 (2012). PMID: 22033490  

34. Patnaik MM, et al., (2012). Differential prognostic effect of IDH1 versus IDH2 mutations in myelodysplastic syndromes: a Mayo Clinic Study of 277 patients. Leukemia 26:101–105, PMID 22033490.

35. Schumacher, T. et al. A vaccine targeting mutant IDH1 induces antitumour immunity. Nature 512, 324 (2014). PMID: 25043048  

35. Schumacher T, et al., (2014). A vaccine targeting mutant IDH1 induces antitumour immunity. Nature 512:324, PMID 25043048.

36. Farshidfar, F. et al. Integrative genomic analysis of cholangiocarcinoma identifies distinct IDH-mutant molecular profiles. Cell Rep. 18, 2780–2794 (2017). PMID: 28658632  

36. Farshidfar F, et al., (2017). Integrative genomic analysis of cholangiocarcinoma identifies distinct IDH-mutant molecular profiles. Cell Rep 18:2780–2794, PMID 28658632.

37. Papaemmanuil, E. et al. Genomic classification and prognosis in acute myeloid leukemia. N. Engl. J. Med. 374, 2209–2221 (2016). PMID: 27276561  

37. Papaemmanuil E, et al., 2016. Genomic classification and prognosis in acute myeloid leukemia. N Engl J Med 374:2209–2221, PMID 27276561.

38. Molenaar, R. J. et al. Clinical and biological implications of ancestral and non-ancestral IDH1 and IDH2 mutations in myeloid neoplasms. Leukemia 29, 2134 (2015). PMID: 25836588  

38. Molenaar RJ, et al., (2015). Clinical and biological implications of ancestral and non-ancestral IDH1 and IDH2 mutations in myeloid neoplasms. Leukemia 29:2134, PMID 25836588.

39. Dang, L. et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462, 739–744 (2009). PMID: 19935646  

39. Dang L, et al., (2009). Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462:739–744, PMID 19935646.

40. Molenaar, R. J., Maciejewski, J. P., Wilmink, J. W. & van Noorden, C. J. F. Wild-type and mutated IDH1/2 enzymes and therapy responses. Oncogene 37, 1949–1960 (2018). PMID: 29367755  

40. Molenaar RJ, et al., (2018). Wild-type and mutated IDH1/2 enzymes and therapy responses. Oncogene 37:1949–1960, PMID 29367755.

41. Gatenby, R. A. & Gillies, R. J. Why do cancers have high aerobic glycolysis? Nat. Rev. Cancer 4, 891–899 (2004). PMID: 15516961  

41. Gatenby RA and Gillies RJ, (2004). Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4:891–899, PMID 15516961.

42. Frezza, C., Tennant, D. A. & Gottlieb, E. IDH1 Mutations in Gliomas: When an Enzyme Loses Its Grip. Cancer Cell 17, 7–9 (2010). PMID: 20129244  

42. Frezza C, et al., (2010). IDH1 mutations in gliomas: when an enzyme loses its grip. Cancer Cell 17:7–9, PMID 20129244.

43. Chan, S. M. et al. Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia. Nat. Med. 21, 178–184 (2015). PMID: 25599133  

43. Chan SM, et al., (2015). Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia. Nat Med 21:178–184, PMID 25599133.

44. Karpel-Massler, G. et al. Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL. Nat. Commun. 8, (2017). PMID: 29057925  

44. Karpel-Massler G, et al., (2017). Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL. Nat Commun 8(2):1067, PMID 29057925.

45. Tateishi, K. et al. Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion. Cancer Cell 28, 773–784 (2015). PMID: 26678339  

45. Tateishi K, et al., (2015). Extreme vulnerability of IDH1 mutant cancers to NAD+ depletion. Cancer Cell 28:773–784, PMID 26678339.

46. Chen, F. et al. Oncometabolites D - and L -2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions. Chem. Res. Toxicol. 30, 1102–1110 (2017). PMID: 28269980  

46. Chen, F. et al. Oncometabolites D - and L -2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions. Chem. Res. Toxicol. 30, 1102–1110 (2017). PMID: 28269980