Changes

=== 4. CANCER CATEGORY/TYPE Section ===

=== 4. CANCER CATEGORY/TYPE Section ===

NOTE:  this section crosses over into the "Disease Pages" in CCGA, and is meant to be a short summary or introduction to the information that is already on the Disease information pages, or will be written there in the future.  This section is to be a list of cancer types important to CCGA, and for the most part, already created cancer disease pages in CCGA.  As you read journal articles and abstracts from Pubmed and content in "World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues" and OMIM, you should be filling in content on this section.  As you come across cancer types that are associated with YGI, you should search CCGA for those diseases (or subclasses of disease) and read the content there.  You should link YGI to the Disease page in CCGA (see examples, below).  You may be able to summarize the content you have found in CCGA disease pages.  The extent of the content should be a short paragraph for each cancer type (1-7 sentences).  The content should include:  the frequency of YGI mutations or fusion genes associated to patients with that specific disease, whether the mutation is a common mutation in that specific disease (if it is uncommon, you are likely NOT to reference that fact), interesting information having to do with drugs, therapy, prognosis and/or outcome.  In some cases, you will find that some CCGA Diseases/Cancer Types have not yet been created.  Please do NOT create a disease page.  Instead, create a new sub heading and write the content in that new section. As CCGA grows, we will add new Diseases/Cancer types and link to the Gene pages later (see example of CML, below).

NOTE:  this section crosses over into the "Disease Pages" in CCGA, and is meant to be a short summary or introduction to the information that is already on the Disease information pages, or will be written there in the future.  This section is to be a list of cancer types important to CCGA, and for the most part, already created cancer disease pages in CCGA.  As you read journal articles and abstracts from Pubmed and content in "World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues" and OMIM, you should be filling in content on this section.  As you come across cancer types that are associated with YGI, you should search CCGA for those diseases (or subclasses of disease) and read the content there.  You should link YGI to the Disease page in CCGA (see examples, below).  You may be able to summarize the content you have found in CCGA disease pages.   

 

The extent of the content should be a short paragraph for each cancer type (1-7 sentences).  The content should include:   

# Frequency of YGI mutations or fusion genes associated to patients with that specific disease,  

# Whether the mutation is a common mutation in that specific disease (if it is uncommon, you are likely NOT to reference that fact),  

# Whether the gene or mutation is a target of drugs

# Whether there are companion diagnostic (in certain therapies) tests based on this gene or mutation(s)

 

In some cases, you will find that some CCGA Diseases/Cancer Types have not yet been created.  Please do NOT create a disease page.  Instead, create a new sub heading and write the content in that new section. As CCGA grows, we will add new Diseases/Cancer types and link to the Gene pages later (see example of CML, below).

The example of RUNX1 is shown below.

The example of RUNX1 is shown below.

Germline mutations of ''RUNX1'' have been reported in the rare autosomal dominant Familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML) [8].

Germline mutations of ''RUNX1'' have been reported in the rare autosomal dominant Familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML) [8].

=== 6. COMMON ALTERATION TYPES Section ===

=== 6. COMMON ALTERATION TYPES Section ===