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| {{Under Construction}} | | {{Under Construction}} |
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− | <blockquote class='blockedit'>{{Box-round|title=HAEM5 Conversion Notes|This page was converted to the new template on 2023-11-30. The original page can be found at [[HAEM4:Splenic Diffuse Red Pulp Small B-cell Lymphoma]]. | + | <blockquote class='blockedit'>{{Box-round|title=HAEM5 Conversion Notes|This page was converted to the new template on 2023-12-04. The original page can be found at [[HAEM4:Splenic Diffuse Red Pulp Small B-cell Lymphoma]]. |
| }}</blockquote> | | }}</blockquote> |
| ==Primary Author(s)*== | | ==Primary Author(s)*== |
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| ==Cancer Category / Type== | | ==Cancer Category / Type== |
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− | *[[Mature B-Cell Neoplasms|Mature B-Cell Neoplasm]] | + | *[[HAEM4:Mature B-Cell Neoplasms|Mature B-Cell Neoplasm]] |
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| ==Cancer Sub-Classification / Subtype== | | ==Cancer Sub-Classification / Subtype== |
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− | *[[Splenic B-cell Lymphoma/Leukemia, Unclassifiable]] | + | *[[HAEM4:Splenic B-cell Lymphoma/Leukemia, Unclassifiable]] |
| | | |
| ==Definition / Description of Disease== | | ==Definition / Description of Disease== |
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| |BRAF p.Val600Glu | | |BRAF p.Val600Glu |
| |Possible role in diagnosis (exclusion) | | |Possible role in diagnosis (exclusion) |
− | |Prevalent in [[Hairy Cell Leukemia|HCL]] but rare/absent in SDRPL<ref name=":3" /> | + | |Prevalent in [[HAEM5:Hairy cell leukaemia|HCL]] but rare/absent in SDRPL<ref name=":3" /> |
| |- | | |- |
| |MAP2K1 | | |MAP2K1 |
| |Possible role in diagnosis (exclusion) | | |Possible role in diagnosis (exclusion) |
− | |Prevalent in [[Hairy Cell Leukemia Variant|HCL-v]] and a subset of cases classified as [[Hairy Cell Leukemia|HCL]] but uncommon in SDRPL<ref name=":3" /> | + | |Prevalent in [[HAEM5:Hairy cell leukaemia Variant|HCL-v]] and a subset of cases classified as [[HAEM5:Hairy cell leukaemia|HCL]] but uncommon in SDRPL<ref name=":3" /> |
| |- | | |- |
| |KLF2 and TNFAIP3 | | |KLF2 and TNFAIP3 |
| |Possible role in diagnosis (exclusion) | | |Possible role in diagnosis (exclusion) |
− | |Prevalent in [[Splenic Marginal Zone Lymphoma|SMZL]] but rare/absent in SDRPL<ref name=":3" /> | + | |Prevalent in [[HAEM5:Splenic marginal zone lymphoma|SMZL]] but rare/absent in SDRPL<ref name=":3" /> |
| |- | | |- |
| |MYD88 | | |MYD88 |
| |Possible role in diagnosis (exclusion) | | |Possible role in diagnosis (exclusion) |
− | |Prevalent in [[Lymphoplasmacytic Lymphoma|LPL]] and [[Splenic Marginal Zone Lymphoma|SMZL]] but rare/absent in SDRPL<ref name=":3" /> | + | |Prevalent in [[HAEM5:Lymphoplasmacytic lymphoma|LPL]] and [[HAEM5:Splenic marginal zone lymphoma|SMZL]] but rare/absent in SDRPL<ref name=":3" /> |
| |- | | |- |
| |BCOR | | |BCOR |
| |Possible role in diagnosis (inclusion) | | |Possible role in diagnosis (inclusion) |
− | |Prevalent in SDRPL but rare/absent in [[Hairy Cell Leukemia|HCL]], [[Hairy Cell Leukemia Variant|HCL-v]], and [[Splenic Marginal Zone Lymphoma|SMZL]]<ref name=":3" /> | + | |Prevalent in SDRPL but rare/absent in [[HAEM5:Hairy cell leukaemia|HCL]], [[HAEM5:Hairy cell leukaemia Variant|HCL-v]], and [[HAEM5:Splenic marginal zone lymphoma|SMZL]]<ref name=":3" /> |
| |} | | |} |
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| *SDRPL is a provisional WHO entity and definitive diagnostic criteria have not been determined | | *SDRPL is a provisional WHO entity and definitive diagnostic criteria have not been determined |
| **Diagnosis of exclusion | | **Diagnosis of exclusion |
− | ***Differential of splenic lymphomas with cytoplasmic projections: [[Hairy Cell Leukemia|HCL]], [[Hairy Cell Leukemia Variant|HCL-v]], [[Splenic Marginal Zone Lymphoma|SMZL]] | + | ***Differential of splenic lymphomas with cytoplasmic projections: [[HAEM5:Hairy cell leukaemia|HCL]], [[HAEM5:Hairy cell leukaemia Variant|HCL-v]], [[HAEM5:Splenic marginal zone lymphoma|SMZL]] |
| **Distinction is by clinical history, morphology, and immunohistochemistry | | **Distinction is by clinical history, morphology, and immunohistochemistry |
| ***No pathognomonic diagnostic markers (molecular or otherwise) | | ***No pathognomonic diagnostic markers (molecular or otherwise) |
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| ==Links== | | ==Links== |
| | | |
− | *[[Hairy Cell Leukemia]] | + | *[[HAEM5:Hairy cell leukaemia]] |
− | *[[Hairy Cell Leukemia Variant]] | + | *[[HAEM5:Hairy cell leukaemia Variant]] |
− | *[[Splenic B-cell Lymphoma/Leukemia, Unclassifiable]] | + | *[[HAEM4:Splenic B-cell Lymphoma/Leukemia, Unclassifiable]] |
− | *[[Splenic Marginal Zone Lymphoma]] | + | *[[HAEM5:Splenic marginal zone lymphoma]] |
| | | |
| ==References== | | ==References== |