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{{DISPLAYTITLE:POEMS Syndrome}}
<blockquote class='blockedit'>{{Box-round|title=PREVIOUS EDITION|This page from the 4th edition of Haematolymphoid Tumours is being updated. See 5th edition [[HAEM5:Table_of_Contents|Table of Contents]].
}}</blockquote>
==Primary Author(s)*==
==Primary Author(s)*==
==Cancer Category/Type==
==Cancer Category/Type==
[[Plasma Cell Neoplasms|Plasma Cell Neoplasm]]
[[HAEM4:Plasma Cell Neoplasms|Plasma Cell Neoplasm]]
==Cancer Sub-Classification / Subtype==
==Cancer Sub-Classification / Subtype==
[[Plasma Cell Neoplasms with Associated Paraneoplastic Syndrome]]
[[HAEM4:Plasma Cell Neoplasms with Associated Paraneoplastic Syndrome]]
==Definition / Description of Disease==
==Definition / Description of Disease==
==Gene Mutations (SNV/INDEL)==
==Gene Mutations (SNV/INDEL)==
A study was conducted in 20 patients of POEMS syndrome. The study showed 7 gene shaving recurrent somatic gene mutations involved in POEMS syndrome. It is important to know that none of the important gene mutations involved in MM such as NRAS, KRAS, BRAF, and TP53 were found in POEMS syndrome patients.<ref>{{Cite journal|last=Nagao|first=Yuhei|last2=Mimura|first2=Naoya|last3=Takeda|first3=June|last4=Yoshida|first4=Kenichi|last5=Shiozawa|first5=Yusuke|last6=Oshima|first6=Motohiko|last7=Aoyama|first7=Kazumasa|last8=Saraya|first8=Atsunori|last9=Koide|first9=Shuhei|date=2019-07|title=Genetic and transcriptional landscape of plasma cells in POEMS syndrome|url=https://www.nature.com/articles/s41375-018-0348-x|journal=Leukemia|language=en|volume=33|issue=7|pages=1723–1735|doi=10.1038/s41375-018-0348-x|issn=1476-5551}}</ref> [[Plasma Cell Neoplasms]]
A study was conducted in 20 patients of POEMS syndrome. The study showed 7 gene shaving recurrent somatic gene mutations involved in POEMS syndrome. It is important to know that none of the important gene mutations involved in MM such as NRAS, KRAS, BRAF, and TP53 were found in POEMS syndrome patients.<ref>{{Cite journal|last=Nagao|first=Yuhei|last2=Mimura|first2=Naoya|last3=Takeda|first3=June|last4=Yoshida|first4=Kenichi|last5=Shiozawa|first5=Yusuke|last6=Oshima|first6=Motohiko|last7=Aoyama|first7=Kazumasa|last8=Saraya|first8=Atsunori|last9=Koide|first9=Shuhei|date=2019-07|title=Genetic and transcriptional landscape of plasma cells in POEMS syndrome|url=https://www.nature.com/articles/s41375-018-0348-x|journal=Leukemia|language=en|volume=33|issue=7|pages=1723–1735|doi=10.1038/s41375-018-0348-x|issn=1476-5551}}</ref> [[HAEM4:Plasma Cell Neoplasms]]
==Links==
==Links==
[[Plasma Cell Neoplasms with Associated Paraneoplastic Syndrome]]
[[HAEM4:Plasma Cell Neoplasms with Associated Paraneoplastic Syndrome]]
==References==
==References==
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome.
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome.
<references group="Epidemiology" />
<references group="Epidemiology" />
[[Category:HAEM4]] [[Category:DISEASE]]