Changes

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{{Under Construction}}

==Primary Author(s)*==

==Primary Author(s)*==

==Cancer Category/Type==

==Cancer Category/Type==

*[[Mature B-Cell Neoplasms]]

*[[HAEM4:Mature B-Cell Neoplasms]]

==Cancer Sub-Classification / Subtype==

==Cancer Sub-Classification / Subtype==

==Definition / Description of Disease==

==Definition / Description of Disease==

Nodal marginal zone lymphoma (NMZL) is an uncommon subtype of non-Hodgkin lymphoma. It is a primary nodal B-cell lymphoma with histological features similar to [[Splenic Marginal Zone Lymphoma|Splenic marginal zone lymphoma]] and [[Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT Lymphoma)|Extranodal marginal zone lymphoma]] involving lymph nodes, but without evidence of splenic or extranodal disease<ref name=":0">Campo E, et al., (2017). Nodal marginal zone lymphoma, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, Revised 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, and Siebert R, Editors. IARC Press: Lyon, France, p263-264.</ref>.

Nodal marginal zone lymphoma (NMZL) is an uncommon subtype of non-Hodgkin lymphoma. It is a primary nodal B-cell lymphoma with histological features similar to [[HAEM5:Splenic marginal zone lymphoma|Splenic marginal zone lymphoma]] and [[HAEM5:Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue|Extranodal marginal zone lymphoma]] involving lymph nodes, but without evidence of splenic or extranodal disease<ref name=":0">Campo E, et al., (2017). Nodal marginal zone lymphoma, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, Revised 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, and Siebert R, Editors. IARC Press: Lyon, France, p263-264.</ref>.

==Synonyms / Terminology<ref name=":0" />==

==Synonyms / Terminology<ref name=":0" />==

*Median age ~60 years old

*Median age ~60 years old

*Both sexes are affected equally

*Both sexes are affected equally

*Cases also occur in children and are separately diagnosed as [[Paediatric Nodal Marginal Zone Lymphoma]]

*Cases also occur in children and are separately diagnosed as [[HAEM5:Paediatric nodal marginal zone lymphoma]]

*Association with autoimmune diseases

*Association with autoimmune diseases

*Association with Hepatitis C virus infection reported in some studies but not all studies

*Association with Hepatitis C virus infection reported in some studies but not all studies

==Links==

==Links==

*[[Paediatric Nodal Marginal Zone Lymphoma]]

*[[HAEM5:Paediatric nodal marginal zone lymphoma]]

*[[Splenic Marginal Zone Lymphoma]]

*[[HAEM5:Splenic marginal zone lymphoma]]

*[[Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT Lymphoma)|Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue]]

*[[HAEM5:Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue|Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue]]

==References==

==References==

<nowiki>*</nowiki>The hierarchical tumour classification structure displayed on this page is reproduced from the [https://tumourclassification.iarc.who.int/welcome/ WHO Classification of Tumours] with permission from the copyright holder, ©International Agency for Research on Cancer.

<nowiki>*</nowiki>The hierarchical tumour classification structure displayed on this page is reproduced from the [https://tumourclassification.iarc.who.int/welcome/ WHO Classification of Tumours] with permission from the copyright holder, ©International Agency for Research on Cancer.