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HAEM4:Myelodysplastic Syndrome with Ring Sideroblasts (MDS-RS) (view source)
Revision as of 16:24, 4 December 2023
, 16:24, 4 December 2023no edit summary
==Characteristic Chromosomal Aberrations / Patterns==
==Characteristic Chromosomal Aberrations / Patterns==
About 10% of MDS-RS-SLD and 50% of MDS-RS-MLD have cytogenetic abnormalities [Cancer Cytogenetics]. These abnormalities mostly involve in single chromosome and are not specific for these disease entities. +8 is the most common chromosome abnormalities in MDS-RS and additional chromosomes reported include -7, 20q-, and -5 <ref>{{Cite journal|last=R|first=Ohba|last2=K|first2=Furuyama|last3=K|first3=Yoshida|last4=T|first4=Fujiwara|last5=N|first5=Fukuhara|last6=Y|first6=Onishi|last7=A|first7=Manabe|last8=E|first8=Ito|last9=K|first9=Ozawa|date=2013|title=Clinical and Genetic Characteristics of Congenital Sideroblastic Anemia: Comparison With Myelodysplastic Syndrome With Ring Sideroblast (MDS-RS)|url=https://pubmed.ncbi.nlm.nih.gov/22983749/|language=en|doi=10.1007/s00277-012-1564-5|pmc=PMC3536986|pmid=22983749}}</ref>. For chromosome abnormalities and prognostic values in MDS, please refer to [[Myelodysplastic Syndromes (MDS)|MDS]].
About 10% of MDS-RS-SLD and 50% of MDS-RS-MLD have cytogenetic abnormalities [Cancer Cytogenetics]. These abnormalities mostly involve in single chromosome and are not specific for these disease entities. +8 is the most common chromosome abnormalities in MDS-RS and additional chromosomes reported include -7, 20q-, and -5 <ref>{{Cite journal|last=R|first=Ohba|last2=K|first2=Furuyama|last3=K|first3=Yoshida|last4=T|first4=Fujiwara|last5=N|first5=Fukuhara|last6=Y|first6=Onishi|last7=A|first7=Manabe|last8=E|first8=Ito|last9=K|first9=Ozawa|date=2013|title=Clinical and Genetic Characteristics of Congenital Sideroblastic Anemia: Comparison With Myelodysplastic Syndrome With Ring Sideroblast (MDS-RS)|url=https://pubmed.ncbi.nlm.nih.gov/22983749/|language=en|doi=10.1007/s00277-012-1564-5|pmc=PMC3536986|pmid=22983749}}</ref>. For chromosome abnormalities and prognostic values in MDS, please refer to [[HAEM4:Myelodysplastic Syndromes (MDS)|MDS]].
==Genomic Gain/Loss/LOH==
==Genomic Gain/Loss/LOH==