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HAEM4:Acute Myeloid Leukemia (AML) with Mutated RUNX1 (view source)
Revision as of 16:27, 4 December 2023
, 16:27, 4 December 2023no edit summary
==Chromosomal Rearrangements (Gene Fusions)==
==Chromosomal Rearrangements (Gene Fusions)==
The ''RUNX1'' gene is involved in the 8;21 translocation (see [http://www.ccga.io/index.php/Acute_Myeloid_Leukemia_(AML)_with_t(8;21)(q22;q22.1);_RUNX1-RUNX1T1 Acute Myeloid Leukemia (AML) with t(8;21)(q22;q22.1); RUNX1-RUNX1T1] page), but the AML with mutated ''RUNX1'' subcategory is specific for those cases with a somatic, acquired mutation in the ''RUNX1'' gene.
The ''RUNX1'' gene is involved in the 8;21 translocation (see [http://www.ccga.io/index.php/HAEM5:Acute_myeloid_leukaemia_with_RUNX1::RUNX1T1_fusion Acute Myeloid Leukemia (AML) with t(8;21)(q22;q22.1); RUNX1-RUNX1T1] page), but the AML with mutated ''RUNX1'' subcategory is specific for those cases with a somatic, acquired mutation in the ''RUNX1'' gene.
==Characteristic Chromosomal Aberrations / Patterns==
==Characteristic Chromosomal Aberrations / Patterns==