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| | ==Definition / Description of Disease== | | ==Definition / Description of Disease== |
Revision as of 14:34, 13 April 2017
Primary Author(s)
Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome.
Cancer Category/Type
Put your text here
Cancer Sub-Classification / Subtype
Put your text here
Definition / Description of Disease
Synonyms / Terminology
Epidemiology / Prevalence
Clinical Features
Sites of Involvement
Morphologic Features
Immunophenotype
| Finding |
Marker
|
| Positive (universal) |
CD1
|
| Positive (subset) |
CD2
|
| Negative (universal) |
CD3
|
| Negative (subset) |
CD4
|
Additional Description:
Chromosomal Rearrangements (Gene Fusions)
| Chromosomal Rearrangement |
Genes in Fusion (5’ or 3’ Segments) |
Pathogenic Derivative |
Prevalence
|
| t(9;22) |
BCR-ABL1 |
der(22) |
5%
|
| t(8;21) |
RUNX1-RUNXT1 |
der(8) |
5%
|
Additional Description:
Characteristic Chromosomal Aberrations / Patterns
Genomic Gain/Loss/LOH
| Chromosome Number |
Gain/Loss/Amp/LOH |
Region
|
| 8 |
Gain |
chr8:0-1000000
|
| 7 |
Loss |
chr7:0-1000000
|
Additional Description:
Gene Mutations (SNV/INDEL)
| Gene |
Mutation |
Oncogene/Tumor Suppressor/Other |
Presumed Mechanism (LOF/GOF/Other; Driver/Passenger) |
Prevalence (COSMIC/TCGA/Other)
|
| TP53 |
R273H |
Tumor Suppressor |
LOF |
20%
|
Additional Description:
- Other Mutations
- Concomitant Mutations
- Secondary Mutations
- Mutually Exclusive
Epigenomics (Methylation)
Genes and Main Pathways Involved
Diagnostic Testing Methods
Clinical Significance (Diagnosis, Prognosis and Therapeutic Implications)
Familial Forms
Other Information
Links
References
Reference Example, BOOK
- Arber DA, Brunning RD, Le Beau MM, Falini B, Vardiman JW, Porwit A, Thiele J, Bloomfield CD (2008). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4thedition.Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, Editors. IARC Press: Lyon, France, p117-118.
Reference Example, Journal Article
- Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GCF, Chan LC, Squire J, Scherer SW and Hitzler JK (2001). Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 28:220-221, PMID 11431691.