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141 bytes added , 14:21, 12 December 2023

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==Cancer Category/Type==

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Myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML)~~, chronic~~ myeloid leukemia (CML)

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*'''[http://www.ccga.io/index.php/Myeloid_Neoplasms_with_Germline_Predisposition Myeloid Neoplasms with Germline Predisposition]'''

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--- '''[http://www.ccga.io/index.php/HAEM4:Myeloid_Neoplasms_with_Germline_GATA2_Mutation Myeloid Neoplasms with Germline GATA2 Mutation]'''

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Myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML)

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Chronic myeloid leukemia (CML)

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Non-small cell lung cancer (NSCLC)

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According to the Catalogue of Somatic Mutations in Cancer (COSMIC), c.490G>A (NM_032638.4) (p.Ala164Thr) and c.15C>G (NM_032638.4) (p.Pro5Pro) have been observed in 49 and 96 cases, respectively, predominantly in the setting of acute myeloid leukemia (https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=GATA2, Accessed 1st August 2018)

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~~{| class~~=~~"wikitable sortable"~~

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==Internal Pages==

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|-

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~~!Copy Number Loss!!Copy Number Gain!!LOH!!Loss-of-Function Mutation!!Gain-of-Function Mutation!!Translocation/Fusion~~

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|-

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~~| || || || || ||~~

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|}

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~~==Internal Pages==~~

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'''[[HAEM5:Acute myeloid leukaemia with MECOM rearrangement]]'''

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[[~~Acute~~ Myeloid ~~Leukemia (AML)~~ with ~~inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2);~~GATA2~~, MECOM~~]]

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'''[[HAEM4:Myeloid Neoplasms with Germline GATA2 Mutation]]'''

==External Links==

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Revision as of 14:21, 12 December 2023