436
edits
Changes
→Cancer Category/Type
Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1
Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1
According to "WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues", blah, blah.
According to "WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues",
"...clinical and morphologic presentations associated with FGFR1 rearrangement are variable, and include not only presentation as a myeloproliferative neoplasm with eosinophilia, but also as AML and they may even present as, or evolve to, precursor T or B lymphoblastic leukaemia/lymphoma with prominent eosinphils." (p.28).
FGFR1 rearrangements are used to rule out diagnoses of Chronic Eosinophilic Leukaemia (p.54) and Myeloproliferative neoplasm,unclassifiable (p.66).
In the case of FGFR1-related disease,
a lymphomatous presentation is common,
particularly T-LBL with accompanying eosinophilia. Other patients have had CEL,
precursor-B lymphoblastic leukaemia/
lymphoma or AML. (.70).
==Gene Overview==
==Gene Overview==