Changes

Losses of 1p, 4p, 4q, 8p, 9p, 9q, 13q, 14q and 18q correlate with higher grade and/or stage of the tumors <ref>Zhang et al, Adv Bioinform, 2010

Losses of 1p, 4p, 4q, 8p, 9p, 9q, 13q, 14q and 18q correlate with higher grade and/or stage of the tumors <ref>Zhang et al, Adv Bioinform, 2010

</ref><ref>Wilhelm et al, Cancer res 2002</ref><ref>Moore LE, Jaeger E, Nickerson ML, Brennan P, De Vries S, Roy R, et al. Genomic copy number alterations in clear cell renal carcinoma: associations with case characteristics and mechanisms of VHL gene inactivation. Oncogenesis. 2012;1 doi: 10.1038/oncsis.2012.14.</ref>

</ref><ref>Wilhelm et al, Cancer res 2002</ref><ref>Moore LE, Jaeger E, Nickerson ML, Brennan P, De Vries S, Roy R, et al. Genomic copy number alterations in clear cell renal carcinoma: associations with case characteristics and mechanisms of VHL gene inactivation. Oncogenesis. 2012;1 doi: 10.1038/oncsis.2012.14.</ref>

<ref>Arai, Eri, Saori Ushijima, Hitoshi Tsuda, Hiroyuki Fujimoto, Fumie Hosoda, Tatsuhiro Shibata, Tadashi Kondo, Issei Imoto, Johji Inazawa, Setsuo Hirohashi, and Yae Kanai. "Genetic Clustering of Clear Cell Renal Cell Carcinoma Based on Array-comparative Genomic Hybridization: Its Association with DNA Methylation Alteration and Patient Outcome." Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 14.17 (2008): 5531-9.</ref><ref>Gunawan et al. Cancer Res 2001</ref>

<ref>Arai, Eri, Saori Ushijima, Hitoshi Tsuda, Hiroyuki Fujimoto, Fumie Hosoda, Tatsuhiro Shibata, Tadashi Kondo, Issei Imoto, Johji Inazawa, Setsuo Hirohashi, and Yae Kanai. "Genetic Clustering of Clear Cell Renal Cell Carcinoma Based on Array-comparative Genomic Hybridization: Its Association with DNA Methylation Alteration and Patient Outcome." Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 14.17 (2008): 5531-9.</ref><ref>Gunawan, Huber, Holtrup, Von Heydebreck, Efferth, Poustka, Ringert, Jakse, and Füzesi. "Prognostic Impacts of Cytogenetic Findings in Clear Cell Renal Cell Carcinoma: Gain of 5q31-qter Predicts a Distinct Clinical Phenotype with Favorable Prognosis." Cancer Research 61.21 (2001): 7731-8.</ref><ref>Monzon et al, Mod Path 2011</ref>  

<ref>Monzon et al, Mod Path 2011</ref>  

and loss of 4, 9p and 14q have been reported as independent prognostic factors for survival in ccRCC<ref>Zhang 2010</ref><ref>Monzon 2011</ref><ref>Klatte 2009</ref><ref>Arai 2008</ref><ref>Alimov et al Int J Oncol 2004; Moch et al 1996</ref>

and loss of 4, 9p and 14q have been reported as independent prognostic factors for survival in ccRCC<ref>Zhang 2010</ref><ref>Monzon 2011</ref><ref>Klatte 2009</ref><ref>Arai 2008</ref><ref>Alimov et al Int J Oncol 2004; Moch et al 1996</ref>