Compendium of Cancer Genome Aberrations

Changes

Breast Cancer Table: Recurrent Genomic Alterations Detected by Chromosomal Microarray (view source)

Revision as of 14:19, 20 April 2021

1,145 bytes added ,  14:19, 20 April 2021
Adding table 4 of the manuscript
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{| class="wikitable"
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|'''Alteration'''
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|'''Relevant Gene(s)'''
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|'''CGC Evidence Level'''
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|'''Subgroup Association(s)'''
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|-
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|1q gain
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| unknown
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|2
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|Most common copy number alteration, often with 16q loss; all subtypes
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|-
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|8p11.2 amplification
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|''FGFR1'', ''ZNF703''
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|2
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|METABRIC IntClust6, ER positive
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|-
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|8q24 amplification
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|''MYC''
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|2
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|METABRIC IntClust9, ER positive
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|-
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|9p24 amplification
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|''JAK2, CD274, PDCD1LG2''
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|2
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|Enriched in TNBC
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|-
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|10q23.3 loss or LOH
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|''PTEN''
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|2
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|Enriched in TNBC and in lobular carcinoma
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|-
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|11q13-q14 gain / amplification
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|''CCND1'', ''EMS1'', and others
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|2
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|METABRIC IntClust2
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|-
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|16q loss / LOH
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|''CDH1''
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|2
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|METABRIC IntClust2, ER positive
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|-
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|17p loss / LOH
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|''TP53''
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|2
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|TNBC, basal-like intrinsic subtype
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|-
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|17q12 amplification
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|''ERBB2'' (''HER2'')
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|1
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|METABRIC IntClust5, HER2-enriched
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|-
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|17q21 amplification
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|''TOP2A''
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|2
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|METABRIC IntClust5, HER2-enriched
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|-
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|17q23 amplification (“17q distal amplicon”)
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|''RPS6KB'', others
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|2
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|METABRIC IntClust1
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|-
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|19q12
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|''CCNE1''
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|2
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|METABRIC IntClust5; HER2-enriched
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|-
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|20q gain; 20q13 amp
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|''AURKA'', ''GNAS'', ''ZNF217''
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|2
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|METABRIC IntClust1, ER Positive
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|}
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