Changes

Abbreviations: TNBC, triple negative breast cancer; LOH, loss of heterozygosity.

Abbreviations: TNBC, triple negative breast cancer; LOH, loss of heterozygosity.

'''Table 2 - Major clinically significant genes associated with somatic sequence alterations in breast cancer.''' Table derived from Geiersbach et al., 2018 [[https://pubmed.ncbi.nlm.nih.gov/32087595/ <nowiki>PMID 32087595</nowiki>]] with permission from Cancer Genetics.

 

'''Table 2 - Major clinically significant genes associated with somatic sequence alterations in breast cancer.''' Table derived from Geiersbach et al., 2018 [[https://pubmed.ncbi.nlm.nih.gov/32087595/ PMID 32087595]] with permission from Cancer Genetics.

{| class="wikitable"

{| class="wikitable"

|'''Gene(s)'''

|'''Gene(s)'''

|PARP inhibitors (germline)

|PARP inhibitors (germline)

|-

|-

|''[[BRCA1 syndrome|BRCA1]], [[BRCA2 syndrome|BRCA2]]''

|''[[BRCA1]], [[BRCA2]]''

|1

|1

|Often hereditary risk; TNBC

|Often hereditary risk; TNBC

'''Table 3 - Genes with known hereditary risk associations in breast cancer.''' Table derived from Geiersbach et al., 2018 [[https://pubmed.ncbi.nlm.nih.gov/32087595/ <nowiki>PMID 32087595</nowiki>]] with permission from Cancer Genetics.

'''Table 3 - Genes with known hereditary risk associations in breast cancer.''' Table derived from Geiersbach et al., 2018 [[https://pubmed.ncbi.nlm.nih.gov/32087595/ PMID 32087595]] with permission from Cancer Genetics.

{| class="wikitable"

{| class="wikitable"

|'''Gene'''

|'''Gene'''

|TNBC

|TNBC

|-

|-

|''BRCA1''

|''[[BRCA1]]''

|[[BRCA1 syndrome|BRCA-Related Breast/ Ovarian Cancer Syndrome]]; TNBC

|[[BRCA1 syndrome|BRCA-Related Breast/ Ovarian Cancer Syndrome]]; TNBC

|-

|-

|''BRCA2''

|''[[BRCA2]]''

|[[BRCA2 syndrome|BRCA-Related Breast/ Ovarian Cancer Syndrome]]; TNBC

|[[BRCA2 syndrome|BRCA-Related Breast/ Ovarian Cancer Syndrome]]; TNBC

|-

|-