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| Abbreviations: TNBC, triple negative breast cancer; LOH, loss of heterozygosity. | | Abbreviations: TNBC, triple negative breast cancer; LOH, loss of heterozygosity. |
| | | |
− | '''Table 2 - Major clinically significant genes associated with somatic sequence alterations in breast cancer.''' Table derived from Geiersbach et al., 2018 [[https://pubmed.ncbi.nlm.nih.gov/32087595/ <nowiki>PMID 32087595</nowiki>]] with permission from Cancer Genetics. | + | |
| + | '''Table 2 - Major clinically significant genes associated with somatic sequence alterations in breast cancer.''' Table derived from Geiersbach et al., 2018 [[https://pubmed.ncbi.nlm.nih.gov/32087595/ PMID 32087595]] with permission from Cancer Genetics. |
| {| class="wikitable" | | {| class="wikitable" |
| |'''Gene(s)''' | | |'''Gene(s)''' |
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| |PARP inhibitors (germline) | | |PARP inhibitors (germline) |
| |- | | |- |
− | |''[[BRCA1 syndrome|BRCA1]], [[BRCA2 syndrome|BRCA2]]'' | + | |''[[BRCA1]], [[BRCA2]]'' |
| |1 | | |1 |
| |Often hereditary risk; TNBC | | |Often hereditary risk; TNBC |
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| | | |
− | '''Table 3 - Genes with known hereditary risk associations in breast cancer.''' Table derived from Geiersbach et al., 2018 [[https://pubmed.ncbi.nlm.nih.gov/32087595/ <nowiki>PMID 32087595</nowiki>]] with permission from Cancer Genetics. | + | '''Table 3 - Genes with known hereditary risk associations in breast cancer.''' Table derived from Geiersbach et al., 2018 [[https://pubmed.ncbi.nlm.nih.gov/32087595/ PMID 32087595]] with permission from Cancer Genetics. |
| {| class="wikitable" | | {| class="wikitable" |
| |'''Gene''' | | |'''Gene''' |
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| |TNBC | | |TNBC |
| |- | | |- |
− | |''BRCA1'' | + | |''[[BRCA1]]'' |
| |[[BRCA1 syndrome|BRCA-Related Breast/ Ovarian Cancer Syndrome]]; TNBC | | |[[BRCA1 syndrome|BRCA-Related Breast/ Ovarian Cancer Syndrome]]; TNBC |
| |- | | |- |
− | |''BRCA2'' | + | |''[[BRCA2]]'' |
| |[[BRCA2 syndrome|BRCA-Related Breast/ Ovarian Cancer Syndrome]]; TNBC | | |[[BRCA2 syndrome|BRCA-Related Breast/ Ovarian Cancer Syndrome]]; TNBC |
| |- | | |- |
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| |} | | |} |
| Abbreviations: TNBC, triple negative breast cancer. | | Abbreviations: TNBC, triple negative breast cancer. |
| + | ==Reference== |
| + | <references /> |