Difference between revisions of "Breast Cancer Table: Recurrent Genomic Alterations Detected by Chromosomal Microarray"

From Compendium of Cancer Genome Aberrations
Jump to navigation Jump to search
VisualWikitext
[unchecked revision][unchecked revision]
(Created page with "Text")
 
(Adding table 4 of the manuscript)
Line 1: Line 1:
−
Text
+
{| class="wikitable"
 +
|'''Alteration'''
 +
|'''Relevant Gene(s)'''
 +
|'''CGC Evidence Level'''
 +
|'''Subgroup Association(s)'''
 +
|-
 +
|1q gain
 +
| unknown
 +
|2
 +
|Most common copy number alteration, often with 16q loss; all subtypes
 +
|-
 +
|8p11.2 amplification
 +
|''FGFR1'', ''ZNF703''
 +
|2
 +
|METABRIC IntClust6, ER positive
 +
|-
 +
|8q24 amplification
 +
|''MYC''
 +
|2
 +
|METABRIC IntClust9, ER positive
 +
|-
 +
|9p24 amplification
 +
|''JAK2, CD274, PDCD1LG2''
 +
|2
 +
|Enriched in TNBC
 +
|-
 +
|10q23.3 loss or LOH
 +
|''PTEN''
 +
|2
 +
|Enriched in TNBC and in lobular carcinoma
 +
|-
 +
|11q13-q14 gain / amplification
 +
|''CCND1'', ''EMS1'', and others
 +
|2
 +
|METABRIC IntClust2
 +
|-
 +
|16q loss / LOH
 +
|''CDH1''
 +
|2
 +
|METABRIC IntClust2, ER positive
 +
|-
 +
|17p loss / LOH
 +
|''TP53''
 +
|2
 +
|TNBC, basal-like intrinsic subtype
 +
|-
 +
|17q12 amplification
 +
|''ERBB2'' (''HER2'')
 +
|1
 +
|METABRIC IntClust5, HER2-enriched
 +
|-
 +
|17q21 amplification
 +
|''TOP2A''
 +
|2
 +
|METABRIC IntClust5, HER2-enriched
 +
|-
 +
|17q23 amplification (“17q distal amplicon”)
 +
|''RPS6KB'', others
 +
|2
 +
|METABRIC IntClust1
 +
|-
 +
|19q12
 +
|''CCNE1''
 +
|2
 +
|METABRIC IntClust5; HER2-enriched
 +
|-
 +
|20q gain; 20q13 amp
 +
|''AURKA'', ''GNAS'', ''ZNF217''
 +
|2
 +
|METABRIC IntClust1, ER Positive
 +
|}

Revision as of 14:19, 20 April 2021

Alteration Relevant Gene(s) CGC Evidence Level Subgroup Association(s)
1q gain unknown 2 Most common copy number alteration, often with 16q loss; all subtypes
8p11.2 amplification FGFR1, ZNF703 2 METABRIC IntClust6, ER positive
8q24 amplification MYC 2 METABRIC IntClust9, ER positive
9p24 amplification JAK2, CD274, PDCD1LG2 2 Enriched in TNBC
10q23.3 loss or LOH PTEN 2 Enriched in TNBC and in lobular carcinoma
11q13-q14 gain / amplification CCND1, EMS1, and others 2 METABRIC IntClust2
16q loss / LOH CDH1 2 METABRIC IntClust2, ER positive
17p loss / LOH TP53 2 TNBC, basal-like intrinsic subtype
17q12 amplification ERBB2 (HER2) 1 METABRIC IntClust5, HER2-enriched
17q21 amplification TOP2A 2 METABRIC IntClust5, HER2-enriched
17q23 amplification (“17q distal amplicon”) RPS6KB, others 2 METABRIC IntClust1
19q12 CCNE1 2 METABRIC IntClust5; HER2-enriched
20q gain; 20q13 amp AURKA, GNAS, ZNF217 2 METABRIC IntClust1, ER Positive
Retrieved from "https://ccga.io/index.php?title=Breast_Cancer_Table:_Recurrent_Genomic_Alterations_Detected_by_Chromosomal_Microarray&oldid=10131"