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BRST5:Secretory Carcinoma (view source)

Revision as of 11:01, 25 October 2022

607 bytes added , 11:01, 25 October 2022

→‎Breast/Secretory Carcinoma

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==Cancer Category/Type==

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Breast

==Cancer Sub-Classification / Subtype==

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Secretory Carcinoma of Breast

==Definition / Description of Disease==

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Secretory carcinoma is a low-grade tumor displaying pushing borders and areas of unequivocal stromal invasion. Tumors may show combinations of microcystic, solid and tubular patterns. The microcystic pattern is composed of irregular shaped small cysts lined with single layer of tumor cells and filled with eosinophilic secretions. The tubular pattern shows luminal eosinophil secretions. The microcystic and tubular patterns can mimic thyroid follicles and can merge into solid islands. Tumor cells are polygonal with granular eosinophilic to foamy cytoplasm. Tumor nuclei are slightly enlarged and regular in shape with inconspicuous nucleoli. Mitotic activity is rare.

==Synonyms / Terminology==

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Synonyms: Juvenile breast carcinoma (historical)

==Epidemiology / Prevalence==

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Secretory carcinomas account for less than 0.05% of all breast cancers. It has been reported in both genders, but predominantly in women.

==Clinical Features==

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{| class="wikitable"

|'''Signs and Symptoms'''

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|~~EXAMPLE Asymptomatic (incidental finding on complete blood counts)~~

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|Well-circumscribed mobile masses

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~~EXAMPLE B~~-~~symptoms (weight loss, fever, night sweats)~~

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~~EXAMPLE Fatigue~~

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~~EXAMPLE Lymphadenopathy (uncommon)~~

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|'''Laboratory Findings'''

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|~~EXAMPLE Cytopenias~~

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|NA

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~~EXAMPLE Lymphocytosis (low level)~~

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==Sites of Involvement==

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The tumors are commonly seen in sub-areolar area.

==Morphologic Features==

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Microcystic, solid and tubular patterns

==Immunophenotype==

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!Finding!!Marker

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|Positive (universal)||~~EXAMPLE CD1~~

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|Positive (universal)||S100, EMA

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|Positive (subset)||~~EXAMPLE CD2~~

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|Positive (subset)||

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|Negative (universal)||~~EXAMPLE CD3~~

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|Negative (universal)||ER, PR, and HER2

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|Negative (subset)||~~EXAMPLE CD4~~

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|Negative (subset)||

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!Notes

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|~~EXAMPLE~~ t(9;22)(~~q34~~;~~q11.2~~)||~~EXAMPLE 3'ABL1 / 5'BCR~~||EXAMPLE der(22)||~~EXAMPLE 20~~% (~~COSMIC~~)

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|t(12;15)(p13;q25)||5’ETV6::3’NTRK3||EXAMPLE der(22)||92% (PMID: 12450792)

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~~EXAMPLE 30% (add reference)~~

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|Yes

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~~|No~~

|Yes

|EXAMPLE

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==Genetic Diagnostic Testing Methods==

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FISH, RT-PCR, RNAseq

==Familial Forms==

Hchen

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