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'''[http://www.ccga.io/index.php/Acute_Myeloid_Leukemia_(AML)_with_BCR-ABL1 Mixed Phenotype Acute Leukemia (MPAL) with BCR-ABL1]'''
'''[http://www.ccga.io/index.php/Acute_Myeloid_Leukemia_(AML)_with_BCR-ABL1 Mixed Phenotype Acute Leukemia (MPAL) with BCR-ABL1]'''
BCR-ABL1 translocations (Ph+) are more prevalent in adult vs. pediatric patients diagnosed as Mixed Phenotype Acute Leukemia (MPAL) [16, 17]. The BCR-ABL1 translocations are considered to be prognostic of poorer outcomes in the context of patients diagnosed with Mixed Phenotype Acute Leukemia (MPAL) [16]. However, a number of individual studies indicate that Ph+ MPAL patients can be treated successfully with tyrosine kinase inhibitors (TKI) such as Imatinab and second generation TKIs (18, 19).
==Gene Overview==
==Gene Overview==
15. Cross NCP and Reiter A, (2002). Tyrosine kinase fusion genes in chronic myeloproliferative diseases. Leukemia 16:1207-1212, PMID 12094244. https://doi.org/10.1038/sj.leu.2402556.
15. Cross NCP and Reiter A, (2002). Tyrosine kinase fusion genes in chronic myeloproliferative diseases. Leukemia 16:1207-1212, PMID 12094244. https://doi.org/10.1038/sj.leu.2402556.
16. Charles NJ and, Boyer DF. (2017). Mixed-Phenotype Acute Leukemia: Diagnostic Criteria and Pitfalls. Arch Pathol Lab Med. 141:1462-1468. PMID 29072953 doi: 10.5858/arpa.2017-0218-RA.
17. Manola KN. (2013). Cytogenetic abnormalities in acute leukaemia of ambiguous lineage: an overview. Br J Haematol. 163:24-39. PMID 23888868 doi: 10.1111/bjh.12484
18. Wolach O and Stone RM. (2014). How I treat mixed-phenotype acute leukemia. Blood 125:2477-2485. PMID 25605373 DOI: 10.1182/blood-2014-10-551465
19. Kawajiri C. et al. (2014). Successful treatment of Philadelphia chromosome-positive mixed phenotype acute leukemia by appropriate alternation of second-generation tyrosine kinase inhibitors according to BCR-ABL1 mutation status. Blood 99:513-8. PMID 24532437 DOI: 10.1007/s12185-014-1531-0
== Notes ==
== Notes ==
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome.
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome.