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→Common Alteration Types
By far the most common ''BCR'' alteration associated with cancer is the BCR-ABL1 fusion as described above in CML and ALL.
By far the most common ''BCR'' alteration associated with cancer is the BCR-ABL1 fusion as described above in CML and ALL.
A small number of individual patients have been described with a BCR-JAK2 (Janus Kinase 2) fusion gene leading to CML and other hematological neoplasms, but this fusion gene appears to be rare (see '''[http://atlasgeneticsoncology.org/Anomalies/t0922p24q11ID1331.html] Atlas of Genetics and Cytogenetics in Oncology and Haematology]''') [12,13,14].
A small number of individual patients have been described with a BCR-JAK2 (Janus Kinase 2) fusion gene leading to CML and other hematological neoplasms, but this fusion gene appears to be rare (see '''[http://atlasgeneticsoncology.org/Anomalies/t0922p24q11ID1331.html] Atlas of Genetics and Cytogenetics in Oncology and Haematology]''') [12,13,14].