3,883
edits
Changes
Acute Myeloid Leukemia (AML) with Mutated FLT3 (view source)
Revision as of 10:07, 18 July 2018
, 10:07, 18 July 2018→Clinical Significance (Diagnosis, Prognosis and Therapeutic Implications)
* Given its prognostic and predictive values, it is argued that ''FLT3'' testing should be performed in all AMLs regardless of cytogenetics [3]. If the ''FLT3''-ITD-to-WT allelic ratio is used for risk stratification, harmonisation of ''FLT3'' testing is essential to ensure that comparable results are achieved [3].
* Given its prognostic and predictive values, it is argued that ''FLT3'' testing should be performed in all AMLs regardless of cytogenetics [3]. If the ''FLT3''-ITD-to-WT allelic ratio is used for risk stratification, harmonisation of ''FLT3'' testing is essential to ensure that comparable results are achieved [3].
* The prognostic significance of ''FLT3''-TKD mutations is controversial and may depend on additional mutations and cytogenetics [3].
==Familial Forms==
==Familial Forms==