Changes

A number of other gene fusion partners have been identified with ''ABL1'' that are linked to hematological cancers, but at a much smaller prevalence than BCR-ABL1.

A number of other gene fusion partners have been identified with ''ABL1'' that are linked to hematological cancers, but at a much smaller prevalence than BCR-ABL1.

* NUP214-ABL1 (associated with T-cell Acute Lymphoblastic Leukemia).

*NUP214-ABL1 (associated with T-cell Acute Lymphoblastic Leukemia).

* ETV6-ABL1 (associated with Chronic Myeloid Leukemia, T-cell Acute Lymphoblastic Leukemia, B-cell Acute Lymphoblastic Leukemia and Acute Myeloid Leukemia), and EML (associated with T-cell Acute Lymphoblastic Leukemia).

*ETV6-ABL1 (associated with Chronic Myeloid Leukemia, T-cell Acute Lymphoblastic Leukemia, B-cell Acute Lymphoblastic Leukemia and Acute Myeloid Leukemia), and EML (associated with T-cell Acute Lymphoblastic Leukemia).

Somatic mutations for ''ABL1'' have been found in Lung Squamous Cell Carcinomas patients (2%), Uterine Corpus Endometrioid Carcinoma patients (3%) and in less than 1% of patients with Breast Invasive Carcinoma, Ovarian Serous Cystadenocarcinoma, and Lung Adenocarcinoma [6].

Somatic mutations for ''ABL1'' have been found in Lung Squamous Cell Carcinomas patients (2%), Uterine Corpus Endometrioid Carcinoma patients (3%) and in less than 1% of patients with Breast Invasive Carcinoma, Ovarian Serous Cystadenocarcinoma, and Lung Adenocarcinoma [6].

{| class="wikitable sortable"

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! Copy Number Loss   !! Copy Number Gain   !! LOH   !!   Loss-of-Function Mutation   !! Gain-of-Function Mutation !! Translocation/Fusion  

!Copy Number Loss!!Copy Number Gain!!LOH!!Loss-of-Function Mutation!!Gain-of-Function Mutation!!Translocation/Fusion

|-

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|   ||   ||   ||   || X || X

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|}

'''[http://www.genecards.org/cgi-bin/carddisp.pl?gene=abl1 ''ABL1'' by GeneCards]''' - general gene information and summaries

'''[http://www.genecards.org/cgi-bin/carddisp.pl?gene=abl1 ''ABL1'' by GeneCards]''' - general gene information and summaries

'''[https://www.ncbi.nlm.nih.gov/gene/25#reference-sequences''ABL1'' by NCBI Gene]''' - general gene information

'''[https://www.ncbi.nlm.nih.gov/gene/25#reference-sequences ''ABL1'' by NCBI Gene]''' - general gene information

'''[http://www.omim.org/entry/189980 ''ABL1'' by OMIM]''' - compendium of human genes and genetic phenotypes

'''[http://www.omim.org/entry/189980 ''ABL1'' by OMIM]''' - compendium of human genes and genetic phenotypes

'''[https://databases.lovd.nl/shared/genes/ABL1 ''ABL1'' by LOVD(3)]''' - Leiden Open Variation Database

'''[https://databases.lovd.nl/shared/genes/ABL1 ''ABL1'' by LOVD(3)]''' - Leiden Open Variation Database

'''[http://www.unav.es/genetica/TICdb/results.php?hgnc=ABL1 ''ABL1'' by TICdb]''' - database of Translocation breakpoints In Cancer

'''[http://www.unav.es/genetica/TICdb/results.php?hgnc=ABL1 ''ABL1'' by TICdb]''' - database of Translocation breakpoints In Cancer

16. Arber DA, et al., (2017). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, Revised 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, and Siebert R, Editors. Revised 4th Edition. IARC Press: Lyon, France, p140.

16. Arber DA, et al., (2017). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, Revised 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, and Siebert R, Editors. Revised 4th Edition. IARC Press: Lyon, France, p140.

== Notes ==

==Notes==

<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page.  If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage).  Additional global feedback or concerns are also welcome.

<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page.  If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage).  Additional global feedback or concerns are also welcome.

[[Category:Cancer Genes A]]

[[Category:Cancer Genes A]]