IGH-EPOR
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Probably specific to the Ph-like subgroup of B-ALL
Iacobucci et al. (2016) identified four types of EPOR rearrangement[1]: :
- Insertion of the EPOR locus distal to the immunoglobulin heavy chain (IGH) locus enhancer
- Insertion of EPOR into the immunoglobulin kappa chain (IGK)
- Reciprocal t(14;19)(q32;p13) rearrangement of IGH to EPOR
- Intrachromosomal inversion of chromosome 19 that juxtaposes
EPOR to the up-stream region ofLAIR1 (leukocyte-associated immunoglobulin- like receptor 1) at chromosome 19q13
- ↑ Iacobucci I, Li Y, Roberts KG, Dobson SM, Kim JC, Payne-Turner D, Harvey RC, Valentine M, McCastlain K, Easton J, Yergeau D, Janke LJ, Shao Y, Chen IM, Rusch M, Zandi S, Kornblau SM, Konopleva M, Jabbour E, Paietta EM, Rowe JM, Pui CH, Gastier-Foster J, Gu Z, Reshmi S, Loh ML, Racevskis J, Tallman MS, Wiernik PH, Litzow MR, Willman CL, McPherson JD, Downing JR, Zhang J, Dick JE, Hunger SP, Mullighan CG. Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia. Cancer Cell. 2016 Feb 8;29(2):186-200. PMID:26859458